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Genetic Basis of Immunodeficiency Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for certified medical advice, calls or professional assistance using a genuine dr.. We aren't physicians. Always confer with your dr. on Genetic Basis of Immunodeficiency conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Genetic Basis of Immunodeficiency Clinical research trials and Genetic Basis of Immunodeficiency medical trials happen in hundreds of localities throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new does drugs. The intent of the studies / undertakings is to answer particular human health questions. Clinical trials are a popular manner for physicians, government agencies, and private sector corporations to find cures for all kinds of circumstances, like Genetic Basis of Immunodeficiency. Genetic Basis of Immunodeficiency Clinical Trials and other clinical trials permit volunteers to acquire healthcare treatment options before they are available to the general public. Some times the subjects acquire professional assistance for free, and sometimes they are paid for their time. Sometimes there is a cost for a Genetic Basis of Immunodeficiency clinical trial. Participants frequently obtain the most expert healthcare available for their Genetic Basis of Immunodeficiency condition. Dangers are a reality, nevertheless, and can include more or frequent doctor calls, health risks (potentially life-jeopardizing), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.
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Home > "G" Clinical Trials Conditions > Genetic Basis of Immunodeficiency  Genetic Basis of Immunodeficiency
Genetic Basis of Immunodeficiency
For Condition: Severe Combined Immunodeficiency
Status: Recruiting
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: This study will examine the role of hereditary factors in different forms of severe combined immunodeficiency (SCID). Patients with immunodeficiencies may be eligible for this study. Candidates include: - Patients with diminished numbers of T cells or NK cells or both, or - Patients with normal T cell and NK cell numbers but diminished T cell, B cell, or NK cell function. Relatives of patients will also be studied. Participants will have blood samples collected for genetic analysis in studies related to SCID at the National Institutes of Health and other institutions.
Details: The goal of this project is to identify the genetic basis of new forms of inherited immunodeficiency. The particular focus relates to cytokines such as IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 that share the common cytokine receptor (Gamma) chain, (Gamma c), and to molecules that are important for signaling in response to these cytokines.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Patients to be included are those with diminished numbers of T cells and/or NK cells or those who have normal T cell and NK cell numbers but diminished T cell, B cell, or NK cell function. Relatives of affected individuals may also be studied. EXCLUSION CRITERIA: Patients to be excluded are those with a known diagnosis or those who are related to an individual with an immunodeficiency of known cause. Other patients may be excluded based on the particular immunological phenotype or the inability of the laboratory to handle additional cases at a given time
Total Enrollment: 1000
Location and Contact Information:
National Heart, Lung and Blood Institute (NHLBI) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 030105; 03-H-0105
Study Start Date: February 14, 2003
Record last reviewed: October 23, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00055172
Other Severe Combined Immunodeficiency Studies:
1. Genetic Basis of Immunodeficiency
2. Influences on Female Adolescents' Decisions Regarding Testing for Carrier Status of XSCID
3. Cord Blood Stem Cell Transplantation Study (COBLT)
4. Genetic Analysis of Immune Disorders
5. Pilot Study of Allogeneic Bone Marrow Transplantation Plus Cyclosporine and Mycophenolate Mofetil to Induce Mixed Hematopoietic Chimerism in Patients With Primary T-Cell Immunodeficiency Disorders
Related Studies:
Other Severe Combined Immunodeficiency Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Genetic Basis of Immunodeficiency
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