|
Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions Clinical Trials Information presented on Clinical Trials Search isn't intended to be a substitute for proven healthcare advice, trips or treatment using a real physician. We are not docs. Always confer with your mD on Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions Clinical research trials and Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions medical trials take place in hundreds of localities across the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually measure the effectiveness of new drugs. The intention of the studies / projects is to resolve certain human health questions. Clinical trials are a popular means for physicians, government agencies, and private sector corporations to detect remedies for all forms of circumstances, like Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions. Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions Clinical Trials and other clinical trials allow for volunteers to undergo healthcare treatment options before they are available to the masses. Most times the participants receive treatment for free, and every now and again they are paid for their time. Occasionally there is a cost for a Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions clinical trial. Subjects typically recieve the finest healthcare available for their Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions condition. Hazards are a reality, nonetheless, and might include more or frequent mD trips, health risks (potentially life-endangering), and/or the treatment being ineffective. Trials are federally regulated with stern guidelines to protect clinical trials subjects.
|
|
|
|
|
|
|
Home > "G" Clinical Trials Conditions > Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions  Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions
Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions
For Condition: Arthritis, Psoriatic,Autoimmune Diseases,Joint Diseases,Osteoarthritis,Rheumatoid Arthritis
Status: Completed
Sponsor(s): National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) ,
Synopsis: This protocol will examine blood, synovial fluid and synovial tissue from patients with rheumatoid arthritis and other chronic inflammatory joint diseases to study genetic and immunologic factors involved in the cause, development and progression of these conditions. Synovial fluid is the lubricating fluid in joints. The synovial membrane is a delicate tissue lining the inner surface of joints, which, in arthritic conditions, thickens and becomes infiltrated with various types of cells. Patients with rheumatoid arthritis and certain patients with other forms of arthritis may be eligible for this study. Those enrolled will be followed periodically for follow-up and disease evaluation. They may undergo the following procedures: 1. Synovial fluid aspiration, when medically indicated (for example, for joint swelling and inflammation). For this procedure, an area of skin around the joint is numbed with an anesthetic, and a needle is inserted into the joint to withdraw a small fluid sample. 2. Periodic blood sampling, not to exceed 450 milliliters (15 ounces) during any 6-week period, for genetic studies of rheumatoid arthritis. The samples are usually taken at the same times that synovial fluid is withdrawn. 3. Synovial tissues, collected by needle biopsy or during surgical procedures for arthroscopy (examination of the interior of the joint and repair of the joint) or total joint replacement. For the needle biopsy, the skin over the biopsy site is washed and anesthetized. A needle is inserted and fluid is aspirated. The biopsy needle is then inserted through the outer needle and a tissue sample is suctioned. Patients who qualify for other research studies may be invited to participate.
Details: Blood, synovial fluids and/or synovial tissues will be obtained from patients with rheumatoid arthritis and related chronic inflammatory arthritides. The synovial tissues will be obtained by one of the following methods: a) needle biopsy, or b) at the time of a total joint replacement or a therapeutic arthroscopic procedure. These materials will be utilized for laboratory studies of etiopathogenetic mechanisms of rheumatoid arthritis and related autoimmune joint diseases.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Patients with rheumatoid arthritis, particularly new onset disease, but certain patients with other forms of arthritis will also be included. Significantly swollen or tender knee or significantly swollen shoulders, elbows, wrists, ankles, olecranon bursa or even smaller joints. Synovial tissue specimens will not be obtained from patients when any of the following conditions are present: abnormal bleeding or clotting tests, platelet count less than 100,000, or sepsis.
Total Enrollment: 9999
Location and Contact Information:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 920065; 92-AR-0065
Study Start Date: December 31, 1991
Record last reviewed: December 17, 1999
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001291
Other Osteoarthritis Studies:
1. A Safety Study of Escalating Doses of PRO70769 for Subjects with Moderate to Severe Rheumatoid Arthritis Receiving Stable Doses of Concomitant Methotrexate
2. Lung Disease Associated with Rheumatoid Arthritis
3. 3 Different Dose Levels Of CCI-779 In Subjects With Active Rheumatoid Arthritis On Concomitant Methotrexate Therapy
4. Study of Families with Twins or Siblings Discordant for Rheumatic Disorders
5. Safety and efficacy of a monoclonal antibody for treatment of rheumatoid arthritis.
Related Studies:
Other Osteoarthritis Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions
|
|
|
|
|
|
|
|
