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Home > "G" Clinical Trials Conditions > Genetic Analysis of Attention Deficit Hyperactivity Disorder (ADHD)  Genetic Analysis of Attention Deficit Hyperactivity Disorder (ADHD)
Genetic Analysis of Attention Deficit Hyperactivity Disorder (ADHD)
For Condition: Attention Deficit Disorder with Hyperactivity
Status: Recruiting
Sponsor(s): National Human Genome Research Institute (NHGRI) ,
Synopsis: Attention Deficit Hyperactivity Disorder (ADHD) is the most common behavioral disorder in childhood, affecting 3-5% of children between the ages of 7 and 17. Family studies suggest that there is a genetic component to ADHD. Scientists believe that it is a complex disorder in which two or more genes may be involved. Potentially eligible families will be asked to give written consent to participate and will be asked to complete questionnaires for each member in the family. In addition, an interview will be administered to the parent of minors enrolled in the study to determine their eligibility for being in the study. This screening tool is computerized and will take approximately 45 minutes to administer per child. Once screenings are completed, a blood collection kit will be sent to the family to take to their local medical care provider, have blood samples drawn and sent to NIH. There is no cost to the family to participate. We would like to enroll entire families, with both parents and all children.
Details: A study of the hypothesis that Attention Deficit Hyperactivity Disorder (ADHD) is a genetically influenced brain disorder has been undertaken using a two armed approach: 1) a large, extended pedigree study done in Columbia, South America in a population isolate called the Paisa; and 2) a U.S. based study with at least one affected child and at least one sibling (either affected or unaffected), and their parents. Following careful phenotyping, DNA from blood samples from these two groups will be analyzed though a genome-wide scan for linkage and positional candidate approach to search for genes associated with ADHD.
Eligibility:
Study Type: Observational, Screening
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: For both the U.S. and the Columbian Studies, we plan to obtain blood samples from subjects meeting the following criteria. Children , ages 7-17, affected with ADHD with siblings who are either affected or unaffected, and their parents. (in the Columbian Study, we will also gather information and blood samples from extended families). EXCLUSION CRITERIA: Exclude the following (if the condition could cause false positive ADHD): Prematurity; neurological conditions; Cardiac surgery; Prenatal drug exposure; Hydrocephaly;Retardation (IQ of less than 80); Known genetic syndromes; Known CNS disorders; Known lead toxicity; Tourette Disorder; Obsessive-Compulsive Disorder; Major Depression on both proband and affected sibling; Pervasive Developmental Disorder; Age under 7 years old; Autism; Other Psychoses; Post Traumatic Stress Disorder; Language Disorder (if known); Severe Sensory Impairment (visual and hearing). No bilineal families are to be included, i.e. families in which both father and mother are known to be affected with ADHD. In order to involve either parent, there must be affected siblings. Include, but note: Oppositional Defiant Disorder; Conduct Disorder; Tic Disorder; Obsessive/Compulsive Symptoms; Anxiety/Phobias
Total Enrollment: 4000
Location and Contact Information:
National Human Genome Research Institute (NHGRI) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 000058; 00-HG-0058
Study Start Date: February 1, 2000
Record last reviewed: January 28, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00046059
Other Attention Deficit Disorder With Hyperactivity Studies:
1. Biological Markers in Attention Deficit/Hyperactivity Disorder (ADHD)
2. Nutrient intake in children with attention deficit hyperactivity disorder
3. Clonidine in Attention Deficit Hyperactivity Disorder (ADHD) in Children
4. Multimodal Treatment Study of Children with Attention Deficit and Hyperactivity Disorder (ADHD)
5. Genetic Analysis of Attention Deficit Hyperactivity Disorder (ADHD)
Related Studies:
Other Attention Deficit Disorder with Hyperactivity Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Genetic Analysis of Attention Deficit Hyperactivity Disorder (ADHD)
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