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Gene Testing in Patients With Colon Cancer Clinical Trials Information presented on Clinical Trials Search isn't designed to be a substitute for certified healthcare advice, travels to or professional assistance using a genuine medical doctor. We are not physicians. Always confer with your dr. about Gene Testing in Patients With Colon Cancer conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Gene Testing in Patients With Colon Cancer Clinical research trials and Gene Testing in Patients With Colon Cancer medical trials happen in hundreds of places across the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually measure the effectualness of new drugs. The intention of the studies / undertakings is to solve certain human healthcare questions. Clinical trials are a popular manner for mDs, government agencies, and private sector companies to locate treatments for all forms of circumstances, such as Gene Testing in Patients With Colon Cancer. Gene Testing in Patients With Colon Cancer Clinical Trials and other clinical trials allow for volunteers to undergo medical treatment choices before they are available to the general public. Some times the human subjects get treatment for free of charge, and sometimes they are paid for their time. Occasionally there is a cost for a Gene Testing in Patients With Colon Cancer clinical trial. Participants frequently get the best healthcare available for their Gene Testing in Patients With Colon Cancer condition. Risks are a reality, nonetheless, and can include extra or frequent physician trips, medical risks (possibly life-jeopardising), and/or the treatment being ineffective. Trials are federally governed with exacting guidelines to protect clinical trials subjects.
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Home > "G" Clinical Trials Conditions > Gene Testing in Patients With Colon Cancer Gene Testing in Patients With Colon Cancer
Gene Testing in Patients With Colon Cancer
For Condition: stage 3 colon cancer,adenocarcinoma of the colon
Status: No longer recruiting
Sponsor(s): National Cancer Institute (NCI) , Cancer and Leukemia Group B
Synopsis: RATIONALE: Analyzing the structure of genes found in a person's cancer cells may help doctors improve methods of treating patients with colon cancer. PURPOSE: Clinical trial to study the genes of patients treated with chemotherapy for colon cancer.
Details: OBJECTIVES: I. Determine the relationship between disease free survival, overall survival, and tumor replication error status for patients who have received adjuvant chemotherapy for colon cancer on CALGB protocol 8896. II. Determine the prognostic and predictive values for response to this therapy in these patients. PROTOCOL OUTLINE: Samples of tumor and normal tissue are obtained from CALGB 8896 patients. The samples are tested for somatic mutations and tumor replication error (RER) tumor status. Patients do not receive the results of the genetic testing and the results do not influence the type or duration of treatment. PROJECTED ACCRUAL: At least 300 specimens will be accrued for this study.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: /
Genders:
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- - Patients who received chemotherapy for colon cancer as part of CALGB protocol 8896 - Underwent an initial resection for adenocarcinoma of the colon and were determined to have a high risk of tumor recurrence based upon nodal disease or local extension of tumor with obstruction or perforation due to tumor - Surgical specimen blocks available, including tumor tissue and normal tissue --Prior/Concurrent Therapy-- - Biologic therapy: Not specified - Chemotherapy: See Disease Characteristics - Endocrine therapy: Not specified - Radiotherapy: Not specified - Surgery: See Disease Characteristics --Patient Characteristics-- - Age: Not specified - Performance status: Not specified - Life expectancy: Not specified - Hematopoietic: Not specified - Hepatic: Not specified - Renal: Not specified
Total Enrollment:
Location and Contact Information:
Overall Study Official:
MonicaBertagnolli, Study Chair, Cancer and Leukemia Group B
Ellis Fischel Cancer Center - Columbia
Columbia, Missouri, 65203
United States
Veterans Affairs Medical Center - Memphis
Memphis, Tennessee, 38104
United States
Veterans Affairs Medical Center - Minneapolis
Minneapolis, Minnesota, 55417
United States
Schneider Children's Hospital at North Shore
Manhasset, New York, 11030
United States
CCOP - North Shore University Hospital
Manhasset, New York, 11030
United States
Dana-Farber Cancer Institute
Boston, Massachusetts, 02115
United States
CCOP - Mount Sinai Medical Center
Miami, Florida, 33140
United States
MBCCOP - Massey Cancer Center
Richmond, Virginia, 23298-0037
United States
Memorial Sloan-Kettering Cancer Center
New York City, New York, 10021
United States
State University of New York - Upstate Medical University
Syracuse, New York, 13210
United States
Veterans Affairs Medical Center - Buffalo
Buffalo, New York, 14215
United States
Lineberger Comprehensive Cancer Center, UNC
Chapel Hill, North Carolina, 27599-7295
United States
CCOP - Southeast Cancer Control Consortium
Winston Salem, North Carolina, 27104-4241
United States
UCSF Cancer Center and Cancer Research Institute
San Francisco, California, 94143-0128
United States
Lombardi Cancer Center
Washington D.C., District of Columbia, 20007
United States
Norris Cotton Cancer Center
Lebanon, New Hampshire, 03756-0002
United States
Roswell Park Cancer Institute
Buffalo, New York, 14263-0001
United States
University of Chicago Cancer Research Center
Chicago, Illinois, 60637-1470
United States
Veterans Affairs Medical Center - White River Junction
White River Junction, Vermont, 05009
United States
Veterans Affairs Medical Center - San Francisco
San Francisco, California, 94121
United States
CCOP - Southern Nevada Cancer Research Foundation
Las Vegas, Nevada, 89106
United States
Arthur G. James Cancer Hospital - Ohio State University
Columbus, Ohio, 43210-1240
United States
University of Massachusetts Memorial Medical Center
Worcester, Massachusetts, 01655
United States
Veterans Affairs Medical Center - Richmond
Richmond, Virginia, 23249
United States
University of Nebraska Medical Center
Omaha, Nebraska, 68198-3330
United States
University of California San Diego Cancer Center
La Jolla, California, 92093-0658
United States
Veterans Affairs Medical Center - Durham
Durham, North Carolina, 27705
United States
New York Presbyterian Hospital - Cornell Campus
New York City, New York, 10021
United States
Mount Sinai Medical Center, NY
New York City, New York, 10029
United States
Walter Reed Army Medical Center
Washington D.C., District of Columbia, 20307-5000
United States
Barnes-Jewish Hospital
St. Louis, Missouri, 63110
United States
Holden Comprehensive Cancer Center at The University of Iowa
Iowa City, Iowa, 52242-1009
United States
University of Tennessee, Memphis Cancer Center
Memphis, Tennessee, 38103
United States
Veterans Affairs Medical Center - Birmingham
Birmingham, Alabama, 35233-1996
United States
Duke Comprehensive Cancer Center
Durham, North Carolina, 27710
United States
Veterans Affairs Medical Center - Chicago (Westside Hospital)
Chicago, Illinois, 60612
United States
Comprehensive Cancer Center at Wake Forest University
Winston Salem, North Carolina, 27157-1082
United States
Veterans Affairs Medical Center - Togus
Togus, Maine, 04330
United States
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
Syracuse, New York, 13217
United States
Veterans Affairs Medical Center - Columbia (Truman Memorial)
Columbia, Missouri, 65201
United States
Marlene & Stewart Greenebaum Cancer Center, University of Maryland
Baltimore, Maryland, 21201
United States
Rhode Island Hospital
Providence, Rhode Island, 02903
United States
Veterans Affairs Medical Center - Syracuse
Syracuse, New York, 13210
United States
CCOP - Christiana Care Health Services
Wilmington, Delaware, 19899
United States
Additional Information:
Study ID Numbers: CDR0000066637; CLB-9865
Study Start Date: August 1998
Record last reviewed: July 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00003571
Other Adenocarcinoma Of The Colon Studies:
1. Chemotherapy in Treating Patients With Colon Cancer That Can Be Surgically Removed
2. Combination Chemotherapy in Treating Patients With Colon Cancer
3. Chemotherapy With Raltitrexed and Fluorouracil in Treating Patients With Advanced Colorectal Cancer
4. FR901228 in Treating Patients With Previously Treated Unresectable Locally Advanced or Metastatic Colorectal Cancer
5. OSI-7904L and Oxaliplatin in Treating Patients With Refractory or Recurrent Advanced Colorectal Cancer
Related Studies:
Other adenocarcinoma of the colon Clinical Trials
Other New York Clinical Trials
Other Buffalo Clinical Trials
Gene Testing in Patients With Colon Cancer
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