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Functional Coupling of Cortico-Cortical and Cortico-Muscular Connections during Motor Movements: An Electrocorticographic Study of Ipsilateral Motor Control Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for certified health advice, travels to or treatment by using a genuine physician. We are not physicians. Always consult your dr. on Functional Coupling of Cortico-Cortical and Cortico-Muscular Connections during Motor Movements: An Electrocorticographic Study of Ipsilateral Motor Control conditions. Clinical Trials Search.org is a site committed to listing clinical research studies in human subjects. Functional Coupling of Cortico-Cortical and Cortico-Muscular Connections during Motor Movements: An Electrocorticographic Study of Ipsilateral Motor Control Clinical research trials and Functional Coupling of Cortico-Cortical and Cortico-Muscular Connections during Motor Movements: An Electrocorticographic Study of Ipsilateral Motor Control health trials occur in hundreds of cities throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically assess the effectivity of new drugs. The propose of the studies / undertakings is to resolve certain human health questions. Clinical trials are a popular means for physicians, government agencies, and private sector companies to locate treatments for all sorts of conditions, including Functional Coupling of Cortico-Cortical and Cortico-Muscular Connections during Motor Movements: An Electrocorticographic Study of Ipsilateral Motor Control. Functional Coupling of Cortico-Cortical and Cortico-Muscular Connections during Motor Movements: An Electrocorticographic Study of Ipsilateral Motor Control Clinical Trials and other clinical trials permit volunteers to acquire medical treatment choices before they are available to the masses. Some times the test subjects obtain professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Functional Coupling of Cortico-Cortical and Cortico-Muscular Connections during Motor Movements: An Electrocorticographic Study of Ipsilateral Motor Control clinical trial. Participants oftentimes recieve the most expert healthcare available for their Functional Coupling of Cortico-Cortical and Cortico-Muscular Connections during Motor Movements: An Electrocorticographic Study of Ipsilateral Motor Control condition. Hazards are a reality, however, and can include extra or frequent physician visits, health risks (potentially life-endangering), and/or the treatment being uneffective. Trials are federally governed with rigorous guidelines to protect clinical trials subjects.
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Home > "F" Clinical Trials Conditions > Functional Coupling of Cortico-Cortical and Cortico-Muscular Connections during Motor Movements: An Electrocorticographic Study of Ipsilateral Motor Control  Functional Coupling of Cortico-Cortical and Cortico-Muscular Connections during Motor Movements: An Electrocorticographic Study of Ipsilateral Motor Control
Functional Coupling of Cortico-Cortical and Cortico-Muscular Connections during Motor Movements: An Electrocorticographic Study of Ipsilateral Motor Control
For Condition: Epilepsy
Status: Recruiting
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: This study examines the relationship between a cerebral hemisphere and control of muscles on the same side of the body (ipsilateral control). One good way to study this relationship is to record electroencephalogram (EEG) activity directly from the cortical surface. Because patients with epilepsy who are surgical candidates are already undergoing monitoring with subdural and/or depth electrodes, they present an opportunity to study ipsilateral control. Studying the electrocorticographic (ECoG) activity associated with simple voluntary movement in such patients would not disturb ongoing monitoring of nearby areas of the brain, nor would it endanger the patients. Ten patients, who may be children or adults, will be recruited for this study. Brain activity will be measured while they move the corner of their mouth and their fingers, wrists, arms, and feet. The baseline measurements will be done with scalp electrodes. Once subdural electrodes have been placed, a second set of measurements will be done. Surface EMG electrodes will be placed on the muscles whose movements are being tested. The tests will be done on no more than 3 separate days, in sessions no longer than 2 hours, for each patient.
Details: A corticomuscular functional relationship has been well addressed in the literature in terms of the control exerted by the primary motor region of the cerebral cortex over the contralateral extremities (Mima and Hallet 1999). However, the relationship between a cerebral hemisphere and ipsilateral motor control is not well understood. We hypothesize that a cortical motor control region ipsilateral to the extremities is located in Brodmann's area 6. There are several methods that can be used to study this relationship in terms of cortical region involved: coherence, correlation, and event-related desynchronization and synchronization. Cortical EEG activity associated with contralateral limb activity or stimulation usually is larger than that associated with ipsilateral limb activity. Furthermore, activity over the scalp that is ipsilateral to motor activity is very small and difficult to identify as compared with that occurring contralaterally. Recording responses directly from the cortical surface would improve the ability to identify this activity. An occasion that would allow us such an opportunity would be invasive monitoring in patients with epilepsy. Epileptic patients who are surgical candidates, but require more precise localization of epileptogenic zones, typically undergo long-term video-EEG monitoring with subdural and/or depth electrodes. Some patients may have seizure onsets close to the sensory-motor area of the brain and require functional mapping in terms of motor function. We would like the opportunity to study electrocorticographic (ECoG) activity associated with simple movements in these patients who are undergoing invasive monitoring. We also would like to include patients who undergo awake craniotomy for resection of brain tumors, epileptic foci and other lesions. This will increase not only a chance of acquiring ECoG data but also a cohort of data sets because subdural recording is notably less frequent. This study will not disturb ongoing monitoring, nor endanger the patient since no activation or stimulation is involved.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: PATIENTS UNDERGOING SUBDURAL IMPLANTATION: Epileptic patients who are undergoing invasive recording with implanted subdural electrodes that cover the sensorimotor cortices. Therefore, we will recruit only those patients with medically intractable epilepsy who are candidates for surgical treatment, and in whom invasive monitoring was deemed necessary for the purpose of precise localization of epileptogenic zones. PATIENTS UNDERGOING AWAKE CRANIOTOMY: Only adult (18 years and older) patients will be recruited for the awake craniotomy study. The patient must understand the nature of the study and must be able to cooperate with the requirements of and tolerate an awake craniotomy for functional mapping. EXCLUSION CRITERIA: EPILEPTIC PATIENTS: Patients whose electrode implantation does not cover the sensorimotor cortices. PATIENTS UNDERGOING AWAKE CRANIOTOMY: Patients whose tumor or other brain lesion(s) do not require mapping of the motor and sensory and supplemental cortex regions via an awake cramiotomy.
Total Enrollment: 35
Location and Contact Information:
National Institute of Neurological Disorders and Stroke (NINDS) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 020199; 02-N-0199
Study Start Date: May 8, 2002
Record last reviewed: February 20, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00036595
Other Epilepsy Studies:
1. Non-Invasive Seizure Localization in Patients with Medically Refractory Localization Related Epilepsy: Synchronized MEG-EEG Recordings
2. Reducing Seizure Frequency Using Cooling of the Head and Neck
3. Early Surgical Intervention to Treat Epilepsy
4. Transcranial Magnetic Stimulation to Treat Epilepsy
5. Search for Genes Influencing Childhood Absence Epilepsy Study
Related Studies:
Other Epilepsy Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Functional Coupling of Cortico-Cortical and Cortico-Muscular Connections during Motor Movements: An Electrocorticographic Study of Ipsilateral Motor Control
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