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Effect of Countermeasures on Nocturnal Driving Performance
Sleep deprivation induces degradation of night-time driving ability via sleepiness. Because of conflicts between physiological needs and social or professional activities, it is necessary to develop affordable countermeasure to sleepiness. In real-life driving studies, nap and coffee are efficient [more...] countermeasures of sleepiness at the wheel. However the effect of caffeine is quick but brief and varies between individuals. There is a need for more knowledge in order to know what to recommend to drivers. Exposure to 460-nm monochromatic light (blue light) decreases subjective sleepiness and improves performances. One objective of this project is to investigate whether blue light exposure during driving would be useful in a real driving situation when sleepiness becomes acute. Owing to the fact that our knowledge of the effects of exercise on driving is very sparse and to the absolutely need to standardize the bouts of exercise that will be applied to the subjects. One objective of the present study will be to investigate in a simulator study the effects of a bout of moderate exercise on participants driving ability when sleepiness becomes acute. Nocturnal neurobehavioral performance varies widely between individuals and only certain subjects seem significantly affected by sleep loss. It is of interest to find biological markers for sleep drive to identify vulnerable drivers to sleep deprivation or to identify responders to sleepiness countermeasures (i.e., coffee and blue light). One objective of this study is to determine individual differences (genetic, hormonal and cognitive) in the impairment of driving skills induced by sleep loss and in the efficiency of countermeasures (blue light and coffee).
Status: Recruiting Start Date: January 2010 Completion Date: February 2012

Multicenter Prospective Study for a Rational Management of Appendicitis in Children
Despite the fact that appendicitis is one of the most frequent surgical pathology in children, its clinical management is still debated. Previous reports have shown rate of appendectomy in children without appendicitis up to 30 %. Morbidity, due to infectious [more...] complications or intestinal obstruction, is often between 5 and 10 % of published cases, and increase medical and social costs. Evidence-based medicine concept could therefore be worthwhile in that context, in order to promote rational diagnosis and treatment of that frequent medical condition.An algorithm describing management of children with suspicion of appendicitis was established, based on recent published data, in order to reduce delay between first clinical signs and confirmation of the diagnosis, and to define therapeutic indication such as conservative management and interval appendectomy or patient requiring laparoscopic approach. The main objective of the study is to decrease morbidity and unnecessary appendectomy rates, and secondly to decrease costs, by the use of that algorithm.
Status: Recruiting Start Date: February 2009 Completion Date: February 2011

Continuous Hemodialysis With an Enhanced Middle Molecule Clearance Membrane
This study aims to demonstrate equivalence in terms of molecule removal between continuous hemodialysis using an "enhanced middle molecule clearance" membrane(Ultraflux EMiC2) and continuous hemofiltration using a standard membrane (Ultraflux AV1000S) in ICU patients requiring continuous renal replacement therapy.
Status: Recruiting Start Date: July 2008 Completion Date: January 2011

Safety and Pharmacokinetic Study With Multiple Ascending Doses of ORM-12741
The purpose of this study is to evaluate the safety and tolerability of multiple ascending doses of ORM-12741.
Status: Recruiting Start Date: February 2010 Completion Date: July 2010

Impact Study of 2 Therapeutic Strategy for Aggressive Remitting Multiple Sclerosis
Cost-effectiveness study of 2 disease-modifying therapies (natalizumab versus mitoxantrone followed by immunomodulator) in the management of aggressive remitting multiple sclerosis
Status: Recruiting Start Date: February 2010 Completion Date: February 2015

Pangenomic Study During Alcoholic Cirrhosis
Hepatocellular carcinoma (HCC) is a frequent complication of cirrhosis. Occurrence of HCC could be linked with multiple functional region of genome. The determining of a genomic mapping of " single nucleotide polymorphisms " (SNPs) permit to perform some [more...] genetic link studies with pathologies without clear hereditary disposition. In this study, the investigators will identify predictives genetic polymorphism of HCC.
Status: Recruiting Start Date: May 2008 Completion Date: May 2011

Optimized Supervised Education Program for Peripheral Arterial Disease
Peripheral arterial disease (PAD) is a frequent and serious chronic disease witch is undertreated. The recommended management of PAD include pharmacological approach and lifestyle modifications. Patient education help to reach this outcome. Our study propose to compare patient education [more...] management with physical activity coaching to usual care.
Status: Recruiting Start Date: February 2010 Completion Date: February 2013

Patients Infected With HIV Since More Than 10 Years With a Plasma Viral RNA <400 Copies / mL in the Absence of Any Treatment: Study Mechanisms Involved in Controlling the Infection
The investigators have previously described a limited group of HIV-1-infected patients, we called HIV controllers (HIC), who have been infected for more than 10 years, in whom viral replication is spontaneously controlled without any treatment. These patients are defined [more...] according to virological criteria: more than 90% of the quantifications of plasma viral load should be less than 400 RNA copies/mL. The purpose of the ANRS EP36 study was to characterize these patients.
Status: Recruiting Start Date: March 2009 Completion Date: March 2012

Observatory on Elderly Patients "Les S.AGES"
Primary objective shared by the 3 registries : Describe the different pharmacotherapeutic management in patients : - DB (Diabetes): with type 2 diabetes, treated with oral and / or injectable [more...] antidiabetics - CP (Chronic Pain): with any disease leading to chronic pain (lasting for more than 3 months) - AF (Atrial Fibrillation): with ongoing AF or AF diagnosed within 12 months before enrollment Secondary objectives shared by the 3 observatories: - Describe the occurrence of clinical events, hospitalizations and death, according to the different medical care conditions, and analyze their predicting factors - Estimate the resources consumption according to the medical and non medical management of these patients, - Analyze the impact of some factors (patient's cognitive status, autonomy, renal function ...) on the current practice Secondary objectives specific shared by DB and AF registries : - Analyze the geriatric pharmaco-genetic aspects Specific secondary objectives for each observatory : - DB : Describe HbA1c level, percentage of responders and body weight evolution according to the different medical care conditions - CP : Evaluate pain consequences on Daily Living Activities and patient autonomy
Status: Recruiting Start Date: April 2009 Completion Date: October 2013

ADDICTAO: Psychological and Addictive Profile of Patients With Buerger's Disease
Background: Buerger's disease (thromboangiitis obliterans or TAO) is a rare disease (1/ 10 000) characterized by the development of segmental thrombotic occlusions of the medium and small arteries of the extremities. Afflicted patients are mostly young, male, inveterate tobacco [more...] smokers (or cannabis) who present with distal extremity ischemia, ischemic ulcers, of the toes or fingers. Large arteries are typically spared, as are the coronary, cerebral, and visceral circulations. Patients with TAO often suffer from severe ischemic pain and tissue loss culminating in minor and major limb amputation. Clinical diagnostic criteria generally include history of tobacco abuse; age of onset less than 50 years; infrapopliteal, segmental arterial occlusions with sparing of the proximal vasculature; frequent distal upper extremity arterial involvement (Raynaud's syndrome or digital ulceration); superficial phlebitis; and exclusion of arteriosclerosis, diabetes, true arteritis, proximal embolic source, and hypercoagulable states. While the cause of Buerger's disease remains unknown, the disease onset and clinical course are inextricably linked to tobacco (or cannabis) abuse. Tobacco abstinence generally results in disease quiescence and remains the mainstay of treatment. For some unknown reason, clinicians observed that TAO patients rarely discontinue smoking even though amputation is usually the inevitable consequence and the only method available of controlling pain and ulceration. Few studies were realized and Hofer-Mayer and al found remarkable personality features comparing to coronary patients: TAO patients significantly changed their place of work more often, had more absenteeism from work, smoked more before the illness and continued to smoke more frequently during their illness, were more often single or divorced and had more conflicts in their relationships. Those facts led us to explore their psychopathology and their addictive profile. Purpose: Search the prevalence of personality disorders in Buerger's patients who present with tobacco or cannabis smoking. Hypothesis: Patients with Buerger's disease show remarkable personality features (psychological and addictive profile) which are vulnerability factors to stop smoking (tobacco or cannabis) compared to patients with atheromatous arteritis.
Status: Recruiting Start Date: September 2008 Completion Date: September 2013

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Clinical trials allow volunteers access to medical treatment options before they are available to the general public. Participants often receive the best healthcare available for their condition.

Risks are a reality, however, and may include more frequent doctor visits, health risks (possibly life-threatening), and/or the treatment being ineffective. Trials are federally regulated with strict guidelines to protect participants.

Disclaimer: The information presented on Clinical Trials Search.org is not in any way intended to be a substitute for professional medical advice/treatment or to replace your relationship with a physician. Always consult your doctor.

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