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Fludarabine With or Without Cyclophosphamide in Treating Patients With Chronic Lymphocytic Leukemia Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for certified medical advice, calls or professional assistance using a genuine dr.. We aren't physicians. Always confer with your dr. on Fludarabine With or Without Cyclophosphamide in Treating Patients With Chronic Lymphocytic Leukemia conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Fludarabine With or Without Cyclophosphamide in Treating Patients With Chronic Lymphocytic Leukemia Clinical research trials and Fludarabine With or Without Cyclophosphamide in Treating Patients With Chronic Lymphocytic Leukemia medical trials happen in hundreds of localities throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new does drugs. The intent of the studies / undertakings is to answer particular human health questions. Clinical trials are a popular manner for physicians, government agencies, and private sector corporations to find cures for all kinds of circumstances, like Fludarabine With or Without Cyclophosphamide in Treating Patients With Chronic Lymphocytic Leukemia. Fludarabine With or Without Cyclophosphamide in Treating Patients With Chronic Lymphocytic Leukemia Clinical Trials and other clinical trials permit volunteers to acquire healthcare treatment options before they are available to the general public. Some times the subjects acquire professional assistance for free, and sometimes they are paid for their time. Sometimes there is a cost for a Fludarabine With or Without Cyclophosphamide in Treating Patients With Chronic Lymphocytic Leukemia clinical trial. Participants frequently obtain the most expert healthcare available for their Fludarabine With or Without Cyclophosphamide in Treating Patients With Chronic Lymphocytic Leukemia condition. Dangers are a reality, nevertheless, and can include more or frequent doctor calls, health risks (potentially life-jeopardizing), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.
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Home > "F" Clinical Trials Conditions > Fludarabine With or Without Cyclophosphamide in Treating Patients With Chronic Lymphocytic Leukemia  Fludarabine With or Without Cyclophosphamide in Treating Patients With Chronic Lymphocytic Leukemia
Fludarabine With or Without Cyclophosphamide in Treating Patients With Chronic Lymphocytic Leukemia
For Condition: stage 2 chronic lymphocytic leukemia,stage 3 chronic lymphocytic leukemia,stage 0 chronic lymphocytic leukemia,B-cell Chronic Lymphocytic Leukemia,stage 1 chronic lymphocytic leukemia,stage 4 chronic lymphocytic leukemia
Status: No longer recruiting
Sponsor(s): Eastern Cooperative Oncology Group , National Cancer Institute (NCI),Cancer and Leukemia Group B,Southwest Oncology Group
Synopsis: RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known whether combining cyclophosphamide with fludarabine is more effective than fludarabine alone in treating chronic lymphocytic leukemia. PURPOSE: Randomizedphase III trial to study the effectiveness of fludarabine with or without cyclophosphamide in treating patients who have chronic lymphocytic leukemia that has not been treated previously.
Details: OBJECTIVES: - Compare the efficacy of fludarabine with or without cyclophosphamide in terms of complete remission rate and overall survival in patients with previously untreated B cell chronic lymphocytic leukemia (CLL). - Compare the toxicities of these 2 regimens in this patient population. - Determine whether the expression of proteins specifically implicated in the regulation of DNA damage induced apoptosis of lymphoid cells (i.e., p53; mdm2; GST; Bcl-2; Mcl-1; Bax; p27; and caspase-3) correlates with response to chemotherapy in these patients. - Determine whether there is a relationship between clinical response or resistance and differential expression of genes in the CLL cells either at initiation of therapy or following relapse and progression. - Correlate mutations in immunoglobulin heavy chain variable region genes with clinical response or resistance in this patient population. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to stage of disease (O-II vs III-IV). Patients are randomized to one of two treatment arms. - Arm I: Patients receive fludarabine IV over 30 minutes on days 1-5. - Arm II: Patients receive fludarabine as in arm I plus cyclophosphamide IV over 1 hour on day 1. Treatment repeats every 28 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients are followed every 3 months for 2 years and then every 6 months until disease progression. PROJECTED ACCRUAL: A total of 280 patients will be accrued for this study over 2 to 2.5 years.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Diagnosis of chronic lymphocytic leukemia (CLL) of any stage as defined by the following: - Peripheral blood absolute lymphocyte count greater than 5,000/mm^3 within 14 days prior to study - Lymphocytes must be small to moderate size with no more than 55% prolymphocytes, atypical lymphocytes, or lymphoblasts morphologically - Phenotypically characterized as B-CLL - Must have one of the following characteristics indicating need for chemotherapy: - Progressive marrow failure (hemoglobin less than 10 g/dL and/or platelet count less than 100,000/mm^3) - Progressive lymphocytosis with an increase of more than 50% over a 2 month period or anticipated doubling time of less than 6 months - Massive (i.e., greater than 6 cm below left costal margin) or progressive splenomegaly - Massive nodes or clusters (i.e., greater than 10 cm in longest diameter) or progressive adenopathy - At least 10% weight loss within 6 months of study - Extreme fatigue - Fevers greater than 100.5 degrees F for 2 weeks without evidence of infection - Night sweats without evidence of infection - No autoimmune anemia or autoimmune thrombocytopenia PATIENT CHARACTERISTICS: Age: - 18 and over Performance status: - ECOG 0-2 Life expectancy: - Not specified Hematopoietic: - See Disease Characteristics Hepatic: - Bilirubin no greater than 2 mg/dL unless secondary to tumor Renal: - Creatinine no greater than 2.0 mg/dL - Creatinine clearance at least 40 mL/min if creatinine is greater than 1.5 mg/dL Other: - No other prior or concurrent malignancy within the past 2 years except basal cell carcinoma of the skin or carcinoma in situ of the cervix - No active infection requiring oral or intravenous antibiotics - Not pregnant or nursing - Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: - Not specified Chemotherapy: - No prior cytotoxic chemotherapy Endocrine therapy: - No prior steroid treatment for CLL Radiotherapy: - Not specified Surgery: - Not specified
Total Enrollment:
Location and Contact Information:
Overall Study Official:
IanFlinn, Study Chair, Sidney Kimmel Cancer Center
CCOP - Bay Area Tumor Institute
Oakland, California, 94609-3305
United States
CCOP - Scott and White Hospital
Temple, Texas, 76508
United States
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, 90095-1781
United States
New Hanover Regional Medical Center
Wilmington, North Carolina, 28402-9025
United States
Veterans Affairs Medical Center - East Orange
East Orange, New Jersey, 07019
United States
MBCCOP - University of New Mexico HSC
Albuquerque, New Mexico, 87131
United States
Veterans Affairs Medical Center - Fargo
Fargo, North Dakota, 58102
United States
David Grant Medical Center
Travis Air Force Base, California, 94535
United States
Veterans Affairs Medical Center - Jackson
Jackson, Mississippi, 39216
United States
Duke Comprehensive Cancer Center
Durham, North Carolina, 27710
United States
University of Mississippi Medical Center
Jackson, Mississippi, 39216-4505
United States
Tufts - New England Medical Center
Boston, Massachusetts, 02111
United States
University of Puerto Rico School of Medicine Medical Sciences Campus
San Juan, , 00936-5067
Puerto Rico
Albert Einstein Clinical Cancer Center
Bronx, New York, 10461
United States
Queens Cancer Center of Queens Hospital
Jamaica, New York, 11432
United States
CCOP - St. Vincent Hospital Cancer Center, Green Bay
Green Bay, Wisconsin, 54307-3453
United States
Holden Comprehensive Cancer Center at University of Iowa
Iowa City, Iowa, 52242-1009
United States
Palm Beach Cancer Institute
West Palm Beach, Florida, 33401
United States
North Shore University Hospital
Manhasset, New York, 11030
United States
Veterans Affairs Medical Center - Charleston
Charleston, South Carolina, 29401-5799
United States
University of Tennessee Cancer Institute
Memphis, Tennessee, 38103
United States
CCOP - Northwest
Tacoma, Washington, 98405-0986
United States
Sky Ridge Medical Center
Lone Tree, Colorado, 80124
United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229-3900
United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center
Maywood, Illinois, 60153-5500
United States
Arizona Cancer Center at University of Arizona Health Sciences Center
Tucson, Arizona, 85724
United States
James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester, New York, 14642
United States
FirstHealth Moore Regional Hospital
Pinehurst, North Carolina, 28374
United States
MBCCOP - Howard University Cancer Center
Washington D.C., District of Columbia, 20060
United States
Hollings Cancer Center at Medical University of South Carolina
Charleston, South Carolina, 29425
United States
Medical Center of Aurora - South Campus
Aurora, Colorado, 80012-0000
United States
Winship Cancer Institute of Emory University
Atlanta, Georgia, 30322
United States
Elmhurst Hospital Center
Elmhurst, New York, 11373
United States
Cancer Research Center at Boston Medical Center
Boston, Massachusetts, 02118
United States
Veterans Affairs Outpatient Clinic - Martinez
Martinez, California, 94553
United States
CCOP - Upstate Carolina
Spartanburg, South Carolina, 29303
United States
Vermont Cancer Center at University of Vermont
Burlington, Vermont, 05401-3498
United States
CCOP - Grand Rapids
Grand Rapids, Michigan, 49503
United States
CCOP - Southeast Cancer Control Consortium
Winston Salem, North Carolina, 27104-4241
United States
Cancer Institute at Oregon Health and Science University
Portland, Oregon, 97201-3098
United States
Rocky Mountain Cancer Centers
Thornton, Colorado, 80260
United States
Arthur G. James Cancer Hospital - Ohio State University
Columbus, Ohio, 43210-1240
United States
CCOP - Sioux Community Cancer Consortium
Sioux Falls, South Dakota, 57104
United States
CCOP - Christiana Care Health Services
Newark, Delaware, 19713
United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, 21231
United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215
United States
Hematology Oncology Associates of the Quad Cities
Bettendorf, Iowa, 52722
United States
UNMC Eppley Cancer Center at the University of Nebraska Medical Center
Omaha, Nebraska, 68198-7680
United States
Ministry Medical Group - Northern Region
Rhinelander, Wisconsin, 54501
United States
University of Chicago Cancer Research Center
Chicago, Illinois, 60637-1470
United States
Oncology and Hematology Associates of Southwest Virginia, Inc.
Roanoke, Virginia, 24014
United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109-0912
United States
Marlene and Stewart Greenebaum Cancer Center, University of Maryland
Baltimore, Maryland, 21201
United States
Providence Cancer Institute at Providence Hospital
Southfield, Michigan, 48075
United States
USC/Norris Comprehensive Cancer Center and Hospital
Los Angeles, California, 90033
United States
Madigan Army Medical Center
Tacoma, Washington, 98431-5000
United States
Barnes-Jewish Hospital
St. Louis, Missouri, 63110
United States
Saint Anthony Medical Center
Rockford, Illinois, 61108
United States
University of Texas Medical Branch
Galveston, Texas, 77555-0565
United States
CCOP - Wichita
Wichita, Kansas, 67214-3882
United States
Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph
Saint Joseph, Michigan, 49085
United States
Veterans Affairs Medical Center - Columbia (Truman Memorial)
Columbia, Missouri, 65201
United States
Veterans Affairs Medical Center - Albuquerque
Albuquerque, New Mexico, 87108-5138
United States
Northeast Alabama Regional Medical Center
Anniston, Alabama, 36207
United States
St. Mary-Corwin Regional Medical Center
Pueblo, Colorado, 81004
United States
Veterans Affairs Medical Center - Little Rock (McClellan)
Little Rock, Arkansas, 72205
United States
Veterans Affairs Medical Center - Dayton
Dayton, Ohio, 45428-1002
United States
Veterans Affairs Medical Center - Ann Arbor
Ann Arbor, Michigan, 48105
United States
Boulder Community Hospital
Boulder, Colorado, 80301-9019
United States
Veterans Affairs Medical Center - White River Junction
White River Junction, Vermont, 05009
United States
Swedish Medical Center
Englewood, Colorado, 80110
United States
Broward General Medical Center
Ft. Lauderdale, Florida, 33316
United States
CCOP - Dayton
Dayton, Ohio, 45429
United States
University of Alabama at Birmingham Comprehensive Cancer Center
Birmingham, Alabama, 35294-3300
United States
CCOP - Western Regional, Arizona
Phoenix, Arizona, 85006-2726
United States
Medical City Dallas Hospital
Dallas, Texas, 75230
United States
Veterans Affairs Medical Center - Shreveport
Shreveport, Louisiana, 71130
United States
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, 44195-9001
United States
MBCCOP - University of Illinois at Chicago
Chicago, Illinois, 60612
United States
Fort Wayne Medical Oncology and Hematology, Incorporated
Ft. Wayne, Indiana, 46885-5099
United States
MBCCOP - Hawaii
Honolulu, Hawaii, 96813
United States
Baptist Hospital East - Louisville
Louisville, Kentucky, 40207
United States
CCOP - Southern Nevada Cancer Research Foundation
Las Vegas, Nevada, 89106
United States
Martha Jefferson Hospital
Charlottesville, Virginia, 22902
United States
Penrose Cancer Center
Colorado Springs, Colorado, 80933
United States
Hillman Cancer Center at University of Pittsburgh Cancer Institute
Pittsburgh, Pennsylvania, 15236
United States
St. Mary's Medical Center
Huntington, West Virginia, 25701
United States
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
Boston, Massachusetts, 02115
United States
Danville Radiation Therapy Center
Memphis, Tennessee, 38104
United States
Tulane University School of Medicine
New Orleans, Louisiana, 70112
United States
Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital)
Hines, Illinois, 60141
United States
Louisiana State University Health Sciences Center - Shreveport
Shreveport, Louisiana, 71130-3932
United States
Veterans Affairs Medical Center - San Antonio (Murphy)
San Antonio, Texas, 78229
United States
Veterans Affairs Medical Center - Phoenix (Carl T. Hayden)
Phoenix, Arizona, 85012
United States
St. Joseph Hospital
Denver, Colorado, 80218-1191
United States
Veterans Affairs Medical Center - Chicago (Westside Hospital)
Chicago, Illinois, 60612
United States
New York Weill Cornell Cancer Center at Cornell University
New York City, New York, 10021
United States
Kansas Cancer Institute at the University of Kansas Medical Center
Kansas City, Kansas, 66160-7353
United States
Western Pennsylvania Hospital
Pittsburgh, Pennsylvania, 15224
United States
Missouri Baptist Cancer Center
St. Louis, Missouri, 63131
United States
NorthEast Oncology Associates
Concord, North Carolina, 28025
United States
MetroHealth Medical Center
Cleveland, Ohio, 44109
United States
Veterans Affairs Medical Center - Amarillo
Amarillo, Texas, 79106
United States
CCOP - Kansas City
Kansas City, Missouri, 64131
United States
CCOP - St. Louis-Cape Girardeau
St. Louis, Missouri, 63141
United States
Veterans Affairs Medical Center - Washington, DC
Washington D.C., District of Columbia, 20422
United States
Veterans Affairs Medical Center - Seattle
Seattle, Washington, 98108
United States
Rebecca and John Moores UCSD Cancer Center
La Jolla, California, 92093-0658
United States
Cooper University Hospital
Camden, New Jersey, 08103
United States
Harrington Cancer Center
Amarillo, Texas, 79106
United States
CCOP - Evanston
Evanston, Illinois, 60201
United States
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago, Illinois, 60611
United States
Louis A. Weiss Memorial Hospital
Chicago, Illinois, 60640
United States
McGill University
Montreal, Quebec, H2W 1S6
Canada
Green Mountain Oncology Group
Bennington, Vermont, 05201
United States
CCOP - Michigan Cancer Research Consortium
Ann Arbor, Michigan, 48106
United States
Veterans Affairs Medical Center - Detroit
Detroit, Michigan, 48201-1932
United States
Veterans Affairs Medical Center - Oklahoma City
Oklahoma City, Oklahoma, 73104
United States
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201-1379
United States
Veterans Affairs Medical Center - Las Vegas
Las Vegas, Nevada, 89106
United States
Veterans Affairs Medical Center - San Francisco
San Francisco, California, 94121
United States
Veterans Affairs Medical Center - Houston
Houston, Texas, 77030
United States
Veterans Affairs Medical Center - New Orleans
New Orleans, Louisiana, 70112
United States
Memorial Sloan-Kettering Cancer Center
New York City, New York, 10021
United States
Penn State Cancer Institute at Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033-0850
United States
Josephine Ford Cancer Center at Henry Ford Hospital
Detroit, Michigan, 48202
United States
CCOP - Montana Cancer Consortium
Billings, Montana, 59101
United States
CCOP - Atlanta Regional
Atlanta, Georgia, 30342-1701
United States
Pretoria Academic Hospital
Pretoria, , 0001
South Africa
MBCCOP - Gulf Coast
Mobile, Alabama, 36688
United States
Walter Reed Army Medical Center
Washington D.C., District of Columbia, 20307-5000
United States
Comprehensive Cancer Center at Wake Forest University
Winston Salem, North Carolina, 27157-1082
United States
Lifespan: The Miriam Hospital
Providence, Rhode Island, 02906
United States
Cape Fear Valley Health System
Fayetteville, North Carolina, 28302-2000
United States
Oklahoma University Medical Center at University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
United States
Herbert Irving Comprehensive Cancer Center at Columbia University
New York City, New York, 10032
United States
Veterans Affairs Medical Center - Atlanta (Decatur)
Decatur, Georgia, 30033
United States
Ellis Fischel Cancer Center at University of Missouri - Columbia
Columbia, Missouri, 65203
United States
Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903
United States
Puget Sound Oncology Consortium
Seattle, Washington, 98109
United States
CCOP - Santa Rosa Memorial Hospital
Santa Rosa, California, 95403
United States
CCOP - Northern Indiana CR Consortium
South Bend, Indiana, 46601
United States
Markey Cancer Center at University of Kentucky Chandler Medical Center
Lexington, Kentucky, 40536-0084
United States
West Suburban Center for Cancer Care
River Forest, Illinois, 60305
United States
Veterans Affairs Medical Center - San Diego
San Diego, California, 92161
United States
University of Texas - MD Anderson Cancer Center
Houston, Texas, 77030-4095
United States
Veterans Affairs Medical Center - Dallas
Dallas, Texas, 75216
United States
Longmont United Hospital
Longmont, Colorado, 80501
United States
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
Syracuse, New York, 13217
United States
Norris Cotton Cancer Center at Dartmouth Medical School
Lebanon, New Hampshire, 03756-0002
United States
Veterans Affairs Medical Center - Buffalo
Buffalo, New York, 14215
United States
CCOP - Beaumont
Royal Oak, Michigan, 48073-6769
United States
CCOP - Merit Care Hospital
Fargo, North Dakota, 58122
United States
University of Massachusetts Memorial Medical Center - University Campus
Worcester, Massachusetts, 01655
United States
CCOP - Colorado Cancer Research Program, Incorporated
Denver, Colorado, 80224
United States
Veterans Affairs Medical Center - Wichita
Wichita, Kansas, 67218
United States
Veterans Affairs Medical Center - Albany
Albany, New York, 12208
United States
CCOP - MainLine Health
Wynnewood, Pennsylvania, 19096
United States
Veterans Affairs Medical Center - Portland
Portland, Oregon, 97207
United States
City of Hope Comprehensive Cancer Center
Duarte, California, 91010-0269
United States
Veterans Affairs Medical Center - Biloxi
Biloxi, Mississippi, 39531-2410
United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
United States
CCOP - Illinois Oncology Research Association
Peoria, Illinois, 61602
United States
Memorial Regional Hospital Comprehensive Cancer Center
Hollywood, Florida, 33021
United States
Veterans Affairs Medical Center - Lakeside Chicago
Chicago, Illinois, 60611-4494
United States
Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas
Dallas, Texas, 75390
United States
Huntsman Cancer Institute
Salt Lake City, Utah, 84112-5550
United States
Presbyterian-St Luke's Medical Center
Denver, Colorado, 80218
United States
Genesis Medical Center
Davenport, Iowa, 52804
United States
CCOP - Columbia River Oncology Program
Portland, Oregon, 97225
United States
CCOP - Cedar Rapids Oncology Project
Cedar Rapids, Iowa, 52403-1206
United States
CCOP - Ochsner
New Orleans, Louisiana, 70121
United States
Lenoir Memorial Hospital Cancer Center
Kinston, North Carolina, 28503-1678
United States
Veterans Affairs Medical Center - Syracuse
Syracuse, New York, 13210
United States
Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center
Orange, California, 92868
United States
Veterans Affairs Medical Center - Tucson
Tucson, Arizona, 85723
United States
Florida Hospital Cancer Institute
Orlando, Florida, 32804
United States
Veterans Affairs Medical Center - Temple
Temple, Texas, 76504
United States
St. Louis University Hospital Cancer Center
St. Louis, Missouri, 63110
United States
Brooke Army Medical Center
Fort Sam Houston, Texas, 78234-6200
United States
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, 33612-9497
United States
Lombardi Cancer Center at Georgetown University Medical Center
Washington D.C., District of Columbia, 20007
United States
CCOP - Marshfield Clinic Research Foundation
Marshfield, Wisconsin, 54449
United States
Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center
Los Angeles, California, 90048
United States
Veterans Affairs Medical Center - Lexington
Lexington, Kentucky, 40502-2236
United States
CCOP - Cancer Research for the Ozarks
Springfield, Missouri, 65807
United States
Veterans Affairs Medical Center - Baltimore
Baltimore, Maryland, 21201
United States
Veterans Affairs Medical Center - Cincinnati
Cincinnati, Ohio, 45220-2288
United States
CCOP - Mount Sinai Medical Center
Miami, Florida, 33140
United States
CCOP - Greenville
Greenville, South Carolina, 29615
United States
CCOP - Iowa Oncology Research Association
Des Moines, Iowa, 50309-1016
United States
MBCCOP - LSU Health Sciences Center
New Orleans, Louisiana, 70112
United States
CCOP - Geisinger Clinic and Medical Center
Danville, Pennsylvania, 17822-2001
United States
Veterans Affairs Medical Center - Kansas City
Kansas City, Missouri, 64128
United States
Veterans Affairs Medical Center - Durham
Durham, North Carolina, 27705
United States
University of Colorado Cancer Center at University of Colorado Health Sciences Center
Aurora, Colorado, 80010
United States
Virginia Oncology Associates - Norfolk
Norfolk, Virginia, 23502
United States
Veterans Affairs Medical Center - Asheville
Asheville, North Carolina, 28805
United States
Rocky Mountain Cancer Centers - Rose
Denver, Colorado, 80220
United States
CCOP - Columbus
Columbus, Ohio, 43206
United States
Veterans Affairs Medical Center - Salt Lake City
Salt Lake City, Utah, 84148
United States
University of Wisconsin Comprehensive Cancer Center
Madison, Wisconsin, 53792-0001
United States
University of Minnesota Cancer Center
Minneapolis, Minnesota, 55455
United States
CCOP - North Shore University Hospital
Manhasset, New York, 11030
United States
CCOP - Virginia Mason Research Center
Seattle, Washington, 98101
United States
CCOP - Carle Cancer Center
Urbana, Illinois, 61801
United States
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
Chapel Hill, North Carolina, 27599-7295
United States
University Hospital at State University of New York - Upstate Medical University
Syracuse, New York, 13210
United States
University of California Davis Cancer Center
Sacramento, California, 95817
United States
Porter Adventist Hospital
Denver, Colorado, 80210
United States
CCOP - Kalamazoo
Kalamazoo, Michigan, 49007-3731
United States
Mayo Clinic Cancer Center
Rochester, Minnesota, 55905
United States
MBCCOP - Massey Cancer Center
Richmond, Virginia, 23298-0037
United States
Veterans Affairs Medical Center - Minneapolis
Minneapolis, Minnesota, 55417
United States
CCOP - Central Illinois
Decatur, Illinois, 62526
United States
CCOP - Metro-Minnesota
St. Louis Park, Minnesota, 55416
United States
Charles M. Barrett Cancer Center at University Hospital
Cincinnati, Ohio, 45267-0501
United States
Mount Sinai Medical Center, NY
New York City, New York, 10029
United States
Additional Information:
Study ID Numbers: CDR0000066890; ECOG-2997,CALGB-10103,SWOG-E2997
Study Start Date:
Record last reviewed: May 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00003764
Other Stage 3 Chronic Lymphocytic Leukemia Studies:
1. Fludarabine With or Without Cyclophosphamide in Treating Patients With Chronic Lymphocytic Leukemia
2. Alemtuzumab Plus Peripheral Stem Cell Transplantation in Treating Patients With Chronic Lymphocytic Leukemia
3. Bryostatin 1 Plus Cladribine in Treating Patients With Relapsed Chronic Lymphocytic Leukemia
4. Cladribine and Rituximab as Remission Induction Therapy Followed By Rituximab and Stem Cell Mobilization in Treating Patients With Chronic Lymphocytic Leukemia
5. Fludarabine in Treating Patients With Chronic Lymphocytic Leukemia
Related Studies:
Other stage 3 chronic lymphocytic leukemia Clinical Trials
Other Virginia Clinical Trials
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Fludarabine With or Without Cyclophosphamide in Treating Patients With Chronic Lymphocytic Leukemia
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