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Home > "F" Clinical Trials Conditions > Familial Aggregation of Barrett's Esophagus  Familial Aggregation of Barrett's Esophagus
Familial Aggregation of Barrett's Esophagus
For Condition: Barrett's Esophagus,Esophageal Neoplasm
Status: Recruiting
Sponsor(s): National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ,
Synopsis: This research study is trying to determine whether Barrett's esophagus and associated esophageal cancers, specifically esophageal adenocarcinoma are inherited in certain families. Persons who are affected with Barrett's esophagus or esophageal cancer (adenocarcinoma type) are asked to complete a questionnaire that determines their habits and asks a detailed family history. Family members of patients seen at University Hospitals of Cleveland are also being recruited for screening tests of their esophagus. The investigators plan to eventually screen family members at all participating institutions. This research will eventually lead to the identification of inherited genetic changes that cause Barrett's esophagus and esophageal cancer. It will help the investigators develop better methods for preventing or identifying esophageal cancer at an early curable stage.
Details:
Eligibility:
Study Type: Observational, Screening, Cross-Sectional, Defined Population, Retrospective/Prospective Study
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Eligible cases will be defined as those patients and their family members who meet the following criteria: - Barrett’s esophagus confirmed by review of pathology and endoscopy report or adenocarcinoma of the esophagus or family members of person with Barrett's esophagus or adenocarcinoma of the esophagus. - Male or female age 18 or older at time of enrollment or male or female less than 18 years of age at time of enrollment with parental consent. - Ability to give informed consent, if patient is age 18 or older. - No history of radiation to the chest or abdomen. - No history of chemotherapy in the year preceding the initial diagnosis of Barrett’s esophagus or esophageal adenocarcinoma.
Total Enrollment: 650
Location and Contact Information:
Cleveland Clinic Foundation *Recruiting*
Cleveland, Ohio,
United States
Recruiting Gary Falk 216-444-1762
Vanderbilt University Medical Center *Recruiting*
Nashville, Tennessee,
United States
Recruiting William Grady 615-322-4207
University Hospitals of Cleveland *Recruiting*
Cleveland, Ohio, 44106-8066
United States
Recruiting Amitabh Chak 216-844-5386
Ohio State University *Recruiting*
Columbus, Ohio,
United States
Recruiting Charis Eng 614-292-2347
Additional Information:
Study ID Numbers: FABE;
Study Start Date:
Record last reviewed: April 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00058877
Other Esophageal Neoplasm Studies:
1. Familial Aggregation of Barrett's Esophagus
2. A Phase II Study of Paclitaxel, UFT, and Leucovorin in Patients with Metastatic Esophageal Cancer
3. The Effects of Upper Airway and Digestive Tract Tumors on the Immune System
4. Vaccine Therapy and Detection of Immunologic Responses with Human Papillomavirus 16 E6 and E7 Peptides in Patients with Metastatic or Locally Advanced Cervical Cancer and Other Cancers Carrying the HPV
Related Studies:
Other Esophageal Neoplasm Clinical Trials
Other Ohio Clinical Trials
Other Cleveland Clinical Trials
Familial Aggregation of Barrett's Esophagus
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