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Home > "E" Clinical Trials Conditions > Evaluation of the Genetics of Bipolar Disorder  Evaluation of the Genetics of Bipolar Disorder
Evaluation of the Genetics of Bipolar Disorder
For Condition: Anxiety Disorder,Bipolar Disorder,Healthy,Mood Disorder,Schizophrenia
Status: Recruiting
Sponsor(s): National Institute of Mental Health (NIMH) ,
Synopsis: The purpose of this study is to identify genes that may affect a person's chances of developing bipolar (BP) disorder and related conditions. BP disorder is a serious and potentially life-threatening mood disorder. The condition can be inherited, but the mode of inheritance is poorly understood and probably involves multiple genes. This study will detect and localize genes that increase or decrease chances of developing BP disorder. Families with siblings who have bipolar disorder will be studied to obtain information for a national archival database of BP disorder genetic data.
Details: Bipolar (BP) affective disorder is a severe, heritable condition affecting about one percent of the population. The mode of inheritance is poorly understood and probably involves multiple loci of small to moderate effect. Genetic linkage has been reported to a number of chromosomal regions; some findings have been replicated. In 1988, the NIMH began a national archival database to search for susceptibility loci/genes in this condition. Its purpose was to collect a large sample of interviews and cells lines from families suitable for linkage and association studies. Since 1988, the NIMH-IRP has been an active site in this multi-center study of bipolar (BP) families, originally supervised by Elliot Gershon, M.D. (1988-July 1998) and since July 1998 by Dennis L. Murphy, M.D. An expanded consortium of sites (including a new site at the University of Chicago headed by Dr. Gershon, and also including the NIMH-IRP site) concentrating on families identified through a sibpair was approved in August 1998 by the NIMH Extramural Program (MH 59535) via a competitive application. It is anticipated that this consortium will add 450 new families and 2500 cell lines and interviews over the next four years. This sample will be used to confirm and extend linkage findings, to narrow the implicated regions and to test candidate genes. Genotypes will be shared within this consortium of investigators studying BP affective disorder. Cell lines and interview data will eventually be made freely available to the scientific community according to NIMH criteria.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Bipolar (manic-depressive) illness: families with two siblings who are Bipolar. Age 18 or over
Total Enrollment: 2900
Location and Contact Information:
National Institute of Mental Health (NIMH) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Diane Kazuba 3014968977
Additional Information:
Study ID Numbers: 800083; 80-M-0083
Study Start Date: August 4, 1980
Record last reviewed: August 13, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001174
Other Bipolar Disorder Studies:
1. Clozapine vs. Placebo in Treatment-Refractory Bipolar Disorder in Children and Adolescents
2. Omega-3 Fatty Acids in the Treatment of Bipolar Disorder: A Double-Blind, Placebo-Controlled Trial
3. Optimizing Electroconvulsive Therapy for Depression
4. Acupuncture as a Supplemental Treatment for Bipolar Depression
5. Olanzapine Versus Active Comparator in the Treatment of Bipolar I Disorder
Related Studies:
Other Bipolar Disorder Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Evaluation of the Genetics of Bipolar Disorder
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