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Evaluation of Opioid Antagonist Activity in Humans - 1



Evaluation of Opioid Antagonist Activity in Humans - 1

For Condition: Opioid-Related Disorders
Status: No longer recruiting
Sponsor(s): National Institute on Drug Abuse (NIDA) , Johns Hopkins University
Synopsis: Evaluate effects of opioid agonist-antagonists in opioid-dependent (maintained) volunteers.
Details: Currently, these human laboratory studies test the pharmacologic effects of buprenorphine/naloxone tablets. The studies determine the efficacy (e.g. blockade), safety, and abuse potential of combination tablets, compared to control conditions.
Eligibility:
Study Type:
  Interventional, Treatment, Randomized, Double-Blind, Uncontrolled
Minimum Age/Maximum Age: 18 Years/55 Years
Genders: Both
Protocol Entry Criteria: Please contact site for information Inclusion Criteria: Opioid abuse/dependence Exclusion Criteria: No significant medical or psychiatric illnesses (besides substance abuse disorder) females not pregnant
Total Enrollment: 154

Location and Contact Information:

Overall Study Official:
EricStrain,  Principal Investigator,  Johns Hopkins University

Johns Hopkins University School of Medicine
Baltimore,  Maryland,  21224
United States
 


Additional Information:
Study ID Numbers:
  NIDA-08045-1;  R01-08045-1
Study Start Date: December 1993
Record last reviewed: December 1993
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00000243

Other Opioid-Related Disorders Studies:
1. Alternate-Day Buprenorphine Administration. Phase VII - 8

2. Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment 1(1) - 1

3. A Phase III Placebo-Controlled, Double-Blind Multi-Site Trial of Lofexidine for Opiate Withdrawal - 1

4. Neurobiology of Opioid Dependence: 4 - 4

5. Alternate Day Buprenorphine Administration, Phase XI - 16

Related Studies:

Other Opioid-Related Disorders Clinical Trials
Other Maryland Clinical Trials
Other Baltimore Clinical Trials

Evaluation of Opioid Antagonist Activity in Humans - 1

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