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Home > "E" Clinical Trials Conditions > Evaluation of Neuromuscular Disease  Evaluation of Neuromuscular Disease
Evaluation of Neuromuscular Disease
For Condition: Healthy,Neuromuscular Disease,Peripheral Nervous System Disease
Status: Completed
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: The peripheral nervous system is the portion of the nervous system outside of the brain and spinal cord. It includes the 12 pairs of cranial nerves, 31 pairs of spinal nerves and their branches, nerves responsible for sensation and maintenance of normal body functions (sympathetic and parasympathetic nerves). Years of research using clinical examinations, microscopic examinations, and electrophysiology have made the peripheral nervous system the best-studied and most available portion of the nervous system. However, even with all of the extensive studies conducted on the peripheral nervous system, many conditions remain unclassified. The EMG Laboratory at the NIH concentrates on studying disorders of the peripheral nervous system. This protocol was designed to allow the EMG Laboratory to; I) Learn more about established diseases of the peripheral nervous system II) Identify and characterize new diseases of the peripheral nervous system III) Assess current techniques in the diagnosis of diseases of the peripheral nervous system IV) Refine old methods and develop new ones for the diagnosis of diseases of the peripheral nervous system.
Details: Combined with careful clinical examination, electrophysiology and histopathology have rendered the peripheral nervous system the best studied and most accessible level of the nervous system. But even after intensive diagnostic evaluation of peripheral neuropathies in large diagnostic centers, 24 to 70% of disorders remain unclassified. Analogous statistics for disorders of muscle and neuromuscular transmission are not known but probably similar, if not worse. Clearly, detailed diagnostic characterization of disorders of the peripheral nervous system is the first stage in clinical intervention. Currently, the EMG Laboratory at the NIH offers complete clinical, electrophysiologic, and, when appropriate, pathologic evaluations on all referrals from the other Branches and Institutes. Since these referrals come primarily from within the NIH, most disorders are secondary to other systemic disease. This protocol is designed to extend the services to direct referrals of primary disorders of the peripheral nervous system. The purposes are first, to learn more about established diseases; second, to identify and characterize new diseases; third, to assess current methodologies and technologies; and fourth, to refine old methods and develop new ones. Under this umbrella protocol, individual cases and clinical series can be investigated.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Patients with disorders of the peripheral nervous system, including neuropathies, myopathies, or defective neuromuscular transmission. Normal age-matched volunteers, including some from within a neurologic population.
Total Enrollment: 1500
Location and Contact Information:
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 840203; 84-N-0203
Study Start Date: October 17, 1984
Record last reviewed: November 27, 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001201
Other Peripheral Nervous System Disease Studies:
1. Evaluation of Neuromuscular Disease
2. Phenotype/Genotype Correlations in Neuromuscular Disorders
3. Electromyography to Diagnose Neuromuscular Disorders
4. Diagnostic Evaluation of Patients with Neuromuscular Disease
Related Studies:
Other Peripheral Nervous System Disease Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Evaluation of Neuromuscular Disease
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