Search Clinical Trials
By Condition
By Location (USA)
By Location (Other)
By Sponsor
Resources
Privacy Policy
About Us
Disclaimer
Evaluation of efficacy, safety and tolerability of Targretin capsules in patients with advanced or metastatic non-small cell lung cancer Clinical Trials Facts presented on Clinical Trials Search is not designed to be a substitute for certified medical advice, travels to or treatment with a real dr.. We aren't doctors. Always consult your mD on Evaluation of efficacy, safety and tolerability of Targretin capsules in patients with advanced or metastatic non-small cell lung cancer conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Evaluation of efficacy, safety and tolerability of Targretin capsules in patients with advanced or metastatic non-small cell lung cancer Clinical research trials and Evaluation of efficacy, safety and tolerability of Targretin capsules in patients with advanced or metastatic non-small cell lung cancer medical trials occur in many of places across the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectiveness of new does drugs. The role of the studies / undertakings is to figure out certain human healthcare questions. Clinical trials are a popular means for doctors, government agencies, and private sector corporations to locate treatments for all forms of circumstances, including Evaluation of efficacy, safety and tolerability of Targretin capsules in patients with advanced or metastatic non-small cell lung cancer. Evaluation of efficacy, safety and tolerability of Targretin capsules in patients with advanced or metastatic non-small cell lung cancer Clinical Trials and other clinical trials permit volunteers to get medical treatment options before they are available to the masses. Most times the human subjects acquire treatment for free of charge, and sometimes they are paid for their time. Occasionally there is a cost for a Evaluation of efficacy, safety and tolerability of Targretin capsules in patients with advanced or metastatic non-small cell lung cancer clinical trial. Participants oftentimes recieve the finest healthcare available for their Evaluation of efficacy, safety and tolerability of Targretin capsules in patients with advanced or metastatic non-small cell lung cancer condition. Dangers are a reality, nonetheless, and might include extra or frequent physician calls, health hazards (potentially life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.

Home > "E" Clinical Trials Conditions > Evaluation of efficacy, safety and tolerability of Targretin capsules in patients with advanced or metastatic non-small cell lung cancer

Evaluation of efficacy, safety and tolerability of Targretin capsules in patients with advanced or metastatic non-small cell lung cancer



Evaluation of efficacy, safety and tolerability of Targretin capsules in patients with advanced or metastatic non-small cell lung cancer

For Condition: Non-small cell lung cancer
Status: No longer recruiting
Sponsor(s): Ligand Pharmaceuticals ,
Synopsis: Ligand Pharmaceuticals Inc. is studying the use of Targretin capsules (bexarotene) in combination with standard chemotherapy for the treatment of metastatic non-small cell lung cancer in patients who have not yet received chemotherapy for their lung cancer.
Details: Ligand Pharmaceuticals Inc. is studying the use of Targretin capsules (bexarotene) in combination with Cisplatin and Vinorelbine for the treatment of metastatic non-small cell lung cancer in patients who have not yet received chemotherapy for their lung cancer. In these studies, every patient receives a platinum-containing chemotherapy every four weeks for at least four chemotherapy cycles (approximately four months). Half of the patients are randomly assigned to receive Targretin capsules once daily in addition to the chemotherapy. The other half is randomized to receive a standard platinum-containing chemotherapy without Targretin capsules.
Eligibility:
Study Type:
  Interventional, Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Safety/Efficacy Study
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Patients must have: - Pathologic (histologic or cytologic) confirmation of NSCLC - Stage IIIB with malignant pleural effusion or Stage IV disease - At least one measurable or evaluable NSCLC lesion that has not been previously irradiated unless radiation therapy was more than three weeks prior to entry in the study and the lesion has been shown to have progressed subsequent to the radiation therapy - ECOG performance status 0 or 1 - Adequate organ system function - Fasting serum triglycerides that are within the age-adjusted normal range (or normalized with appropriate intervention such as antilipid therapy prior to the initiation of Targretin capsule therapy). Patients must be able to complete at least four cycles of combination chemotherapy (i.e., approximately four months) Patients must not have had: - Brain metastasis - Prior chemotherapy for NSCLC - Prior platinum-based chemotherapy for any indication
Total Enrollment: 600

Location and Contact Information:

Overall Study Official:
MackMabry,  Study Director,  Ligand Pharmaceuticals

SUNY Downstate Medical Center
Brooklyn,  New York,  11203
United States
 

VA Western New York Health Care System
Buffalo,  New York,  14215
United States
 

7th Pneumonology Clinic, Sotiria Hospital for Diseases of the Chest
Athens,  ,  11527
Greece
 

Institut Jean Godinot
Reims,  Cedex,  51100
France
 

Centrum Onkologii Instytut im. M. Sklodowskiej-Curie
Krakow,  ,  31-115
Poland
 

Bay Area Cancer Consultants
Palm Harbor,  Florida,  34684
United States
 

Hematology-Oncology Associates
Toledo,  Ohio,  43623
United States
 

2nd Pulmonary Clinic of G. Papanikolaou Hospital
Exochi,  Thessaloniki,  57010
Greece
 

Nemocnice odd. Onkologie
Ceske Budejovice,  ,  370 87
Czech Republic
 

Tel-Aviv Sovrasky Medical Center
Tel Aviv,  ,  64239
Israel
 

Research Institute of Oncology n.a. Hertzen
Moscow,  ,  12584
Russian Federation
 

Brookwood Medical Center
Birmingham,  Alabama,  35209
United States
 

Northwest Medical Specialists
Arlington Heights,  Illinois,  60004
United States
 

Port Macquarie Base Hospital
Port Macquarie,  New South Wales,  2444
Australia
 

Burnside War Memorial Hospital
Toorak Gardens,  South Australia,  5065
Australia
 

Tariq Mahmood
Midwest City,  Oklahoma,  73110
United States
 

City Oncology Clinical Center
Moscow,  ,  107005
Russian Federation
 

Louisiana State University Health Science Center
New Orleans,  Louisiana,  70112
United States
 

Centre Hospitalier Intercommunal de la Haute-Saone
Vesoul,  Cedex,  70014
France
 

Centre Hospitalier General de Belfort
Belfort,  Cedex,  90016
France
 

6th Pneumonology Department, Sotiria Hospital for Diseases of the Chest
Athens,  ,  11527
Greece
 

Regionalne Centrum Onkologii
Bialystok,  ,  15-027
Poland
 

Instytut Gruzlicy i Chorob Pluc
Warsaw,  ,  01-138
Poland
 

Klinika pneumologie a hrudni chirurgie 3.LF
Praha-8,  ,  CZ-180 00
Czech Republic
 

Bristol Hematology and Oncology Centre
Bristol,  England,  BS2 8ED
United Kingdom
 

Veterans Affairs Medical Center
Miami,  Florida,  33125
United States
 

1st Pulmonary Clinic of G. Papanikolaou Hospital
Exochi,  Thessaloniki,  57010
Greece
 

Cancer Care Manitoba
Winnepeg,  Manitoba,  R3E 0V9
Canada
 

University General Hospital of Heraklion
Heraklion,  Crete, 
Greece
 

Royal Hobart Hospital
Hobart,  Tasmania,  7001
Australia
 

Sheba Medical Center
Tel Hashomer,  ,  52620
Israel
 

Medical Associates Health Centers
Menomonee Falls,  Wisconsin,  53051
United States
 

Arroyo Research Inc.
Pasadena,  California,  91105
United States
 

Chelsea & Westminster Hospital
London,  England,  SW10 9NH
United Kingdom
 

University of Florida
Gainesville,  Florida,  32610
United States
 

City Oncology Center
St Petersburg,  ,  197022
Russian Federation
 

St. Joseph Mercy Oakland Hospital
Pontiac,  Michigan,  48341
United States
 

Queen Elizabeth Hospital
Woodville,  South Australia,  5011
Australia
 

University Hospital of Patras
Rio,  ,  26500
Greece
 

Canberra Hospital
Garran,  Australian Capital Territory,  2605
Australia
 

St. Petersburg Pavlov State Medical University
St Petersburg,  ,  197089
Russian Federation
 

QEII Health Sciences Center
Halifax,  Nova Scotia,  B3H 1V7
Canada
 

Aberdeen Royal Infirmary
Foresterhill,  Aberdeen,  AB25 2ZN
United Kingdom
 

Tom Baker Cancer Centre
Calgary,  Alberta,  T2N 4N2
Canada
 

Pneumologicka klinika 1. LF UK
Praha-6-Veleslavin,  ,  CZ-160 00
Czech Republic
 

Assaf Harofeh Medical Center
Zerifin,  ,  70300
Israel
 

Semmelweis University Department of Pulmonology
Budapest,  ,  1125
Hungary
 

Desert Hematology-Oncology Medical Group, Inc.
Rancho Mirage,  California,  92270
United States
 

Southern Arizona VA Healthcare System
Tucson,  Arizona,  85723
United States
 

Border Medical Oncology
Wodonga,  Victoria,  3690
Australia
 

Russian Oncology Research Center n.a. Blokhin
Moscow,  ,  115478
Russian Federation
 

Marshfield Medical Research Foundation
Marshfield,  Wisconsin,  54449
United States
 

Ottawa Regional Cancer Centre
Ottawa,  Ontario,  K1H 1C4
Canada
 

Koranyi National Institute for Pulmonology
Budapest,  ,  1529
Hungary
 

Kaplan Medical Center
Rehovot,  ,  76100
Israel
 

Capitol Comprehensive Cancer Care Clinic
Jefferson City,  Missouri,  65109
United States
 

City Oncology Hospital #62
Moscow,  ,  143423
Russian Federation
 

Jayne Gurtler, M.D., APMC
Metairie,  Louisiana,  70006
United States
 

Arkhangelsk Regional Oncology Center
Arkhangelsk,  ,  163045
Russian Federation
 

Box Hill Hospital
Box Hill,  Victoria,  3128
Australia
 

Hadassah Medical Center
Jerusalem,  ,  19200
Israel
 

Research Institute of Oncology n.a. Petrov
St Petersburg,  ,  197758
Russian Federation
 

Csongrad Megyei Onkormanyzat Mellkasi
Deszk,  ,  6772
Hungary
 

Barzilai Medical Centre
Ashkelon,  ,  78308
Israel
 

Southern Medical Daycare Centre
Wollongong,  New South Wales,  2500
Australia
 

Fovarosi Onkormanyzat Uzsoki utcai, Korhaza
Budapest,  ,  1145
Hungary
 

Meir Hospital
Kfar Sava,  ,  44281
Israel
 

New Hope Cancer Center
Hudson,  Florida,  34667
United States
 

University Hospital of Alexandroupolis
Dragana,  Alexandroupolis,  68100
Greece
 

University Oncology & Hematology Associates
Chattanooga,  Tennessee,  37404
United States
 

Centre Hospitalier Francois Maillot
Briey,  Cedex,  54150
France
 

Wielkopolskie Centrum Chorob Pluc I Gruzlicy
Poznan,  ,  66-569
Poland
 

Central Clinical Hospital n.a. Semashko
Moscow,  ,  129128
Russian Federation
 

Akademii Medycznej w Gdansku
Gdansk,  ,  80-216
Poland
 

Leicester Royal Infirmary
Leicester,  England,  LE1 5WW
United Kingdom
 

Guys & St. Thomas' Cancer Centre
London,  England,  SE1 9RT
United Kingdom
 

University of Edinburgh
Edinburgh,  Scotland,  EH4 2XU
United Kingdom
 


Additional Information:
Study ID Numbers:
  L1069-49; 
Study Start Date: 
Record last reviewed: August 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00050973

Other Non-Small Cell Lung Cancer Studies:
1. Comparison of Two Combination Chemotherapy Regimens in Treating Non-small Cell Lung Cancer

2. Docetaxel and Gemcitabine with Filgrastim-SD/01 Support in Patients with Advanced Non-Small Cell Lung Carcinoma

3. Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy

4. A Study Of Oral GW572016 In Advanced Or Metastatic Non-Small Cell Lung Cancer

5. Computed Tomography for Early Detection of Cancer in Women Who Are at Risk for Lung Cancer

Related Studies:

Other Non-small cell lung cancer Clinical Trials
Other Clinical Trials
Other Warsaw Clinical Trials

Evaluation of efficacy, safety and tolerability of Targretin capsules in patients with advanced or metastatic non-small cell lung cancer

Modify your Search

  Other Non-small cell lung cancer Clinical Trials
  Other Clinical Trials
  Other Warsaw Clinical Trials


Warning: include(/var/www/cgi-bin/traxis/counter.php) [function.include]: failed to open stream: No such file or directory in /home/cts/domains/clinicaltrialssearch.org/public_html/index.php on line 103

Warning: include() [function.include]: Failed opening '/var/www/cgi-bin/traxis/counter.php' for inclusion (include_path='.:/usr/local/lib/php') in /home/cts/domains/clinicaltrialssearch.org/public_html/index.php on line 103