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Evaluation and Treatment of Skeletal Diseases Clinical Trials Information presented on Clinical Trials Search is not designed to be a substitute for certified medical advice, trips or professional assistance with a real medical doctor. We aren't docs. Always confer with your doctor about Evaluation and Treatment of Skeletal Diseases conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Evaluation and Treatment of Skeletal Diseases Clinical research trials and Evaluation and Treatment of Skeletal Diseases health trials happen in many of cities across the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally measure the effectualness of new does drugs. The intention of the studies / projects is to figure out particular human healthcare questions. Clinical trials are a popular manner for doctors, government agencies, and private sector corporations to detect cures for all forms of circumstances, like Evaluation and Treatment of Skeletal Diseases. Evaluation and Treatment of Skeletal Diseases Clinical Trials and other clinical trials allow for volunteers to undergo medical treatment options before they are available to the general public. Most times the subjects get treatment for free of charge, and occasionally they are paid for their time. Occasionally there is a cost for a Evaluation and Treatment of Skeletal Diseases clinical trial. Subjects frequently get the best healthcare possible for their Evaluation and Treatment of Skeletal Diseases condition. Hazards are a reality, however, and could include more or frequent mD visits, health risks (possibly life-jeopardizing), and/or the treatment being ineffectual. Trials are federally regulated with exacting guidelines to protect clinical trials patients.
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Home > "E" Clinical Trials Conditions > Evaluation and Treatment of Skeletal Diseases  Evaluation and Treatment of Skeletal Diseases
Evaluation and Treatment of Skeletal Diseases
For Condition: Bone Disease
Status: Recruiting
Sponsor(s): National Institute of Dental and Craniofacial Research (NIDCR) ,
Synopsis: This study has four objectives: 1) to provide investigators the opportunity to study bone specimens from patients with various skeletal diseases; 2) to treat patients with skeletal diseases at the NIH; 3) to expose NIH trainees to certain skeletal diseases; and 4) to gain more knowledge about skeletal diseases and stimulate further study of bone biology. Anyone with a disease that affects the skeleton may be eligible for this study. All evaluations, tests, procedures and treatments given study participants are used in the standard care of skeletal diseases. No experimental evaluations or treatments are offered. Patient evaluations include a medical history, review of medical records and routine physical examination. Based on the findings, other procedures may be recommended, including blood tests, urine tests, and imaging tests, such as X-rays, bone densitometry, bone scan, computed tomography (CT) and magnetic resonance imaging (MRI). Bone specimens from participants will be collected for research use. Specimens will be obtained from bone removed during a patient's planned surgical procedure performed for medical care, or patients may be requested to have a bone biopsy-removal of a small piece of bone tissue-as part of the patient evaluation procedure.
Details: Human diseases are commonly manifested in the skeletal system. The skeleton may be the primary or secondary target of the disease and the disease may be congenital or acquired. While understanding of the molecular and cellular biology of the bone has blossomed in the last several years, much remains to be understood about the underlying biology of the skeleton. The gaps in the understanding of skeletal biology are evident in the paucity of tissue-specific therapies for skeletal diseases. The objectives of this protocol are fourfold: 1) to allow us to receive bone specimens from investigators outside the NIH, 2) to provide a protocol within which patients with skeletal disease can be evaluated and treated here at NIH, 3) to provide a protocol under which trainees can evaluate patients with skeletal diseases and 4) to provide a pool of patients with skeletal diseases from which questions of basic pathogenetic mechanisms may serve as the basis for future studies. Within this study, bone formation will be assessed using cell and molecular biological approaches when specimens are sent from outside of NIH, and when recruited to NIH, patients will undergo clinically-indicated testing and possibly receive treatment which will be limited to approved medications.
Eligibility:
Study Type: Interventional, Training
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Specimens to be shipped will be considered either "surgical waste" or the harvesting of the specimen will be approved by an IRB-approved protocol at the sending institution. The specimen will be sent with a copy of the signed consent. Patients of any age, gender, or ethnicity with skeletal diseases who are not enrolled in other protocols which otherwise allow for the evaluation and treatment of these diseases. Women of childbearing age or lactating will have pregnancy ruled-out with a serum pregnancy test and/or not undergo testing involving radiation or receive medications without demonstrated safety in pregnancy. Patients must be referred from a practitioner who will continue their care/evaluation upon discharge, or in tandem with this protocol. EXCLUSION CRITERIA: Patients with significant cognitive impairment who are unable to give informed consent. Patients with achondroplasias are often mentally compromised. Patients with serious, uncontrolled metabolic organ system dysfunction (decompensated heart failure, diabetes, etc.).
Total Enrollment: 999999
Location and Contact Information:
National Institute of Dental And Craniofacial Research (NIDCR) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 010184; 01-D-0184
Study Start Date: September 25, 2001
Record last reviewed: August 3, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00024804
Other Bone Disease Studies:
1. Bone Regeneration Using Stromal Cells
2. Evaluation and Treatment of Skeletal Diseases
Related Studies:
Other Bone Disease Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Evaluation and Treatment of Skeletal Diseases
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