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Etoposide in Treating Patients With Relapsed Non-Hodgkin's Lymphoma Clinical Trials Resources presented on Clinical Trials Search is not meant to be a substitute for proven health advice, calls or treatment with a real medical. We aren't mDs. Always consult your doctor on Etoposide in Treating Patients With Relapsed Non-Hodgkin's Lymphoma conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Etoposide in Treating Patients With Relapsed Non-Hodgkin's Lymphoma Clinical research trials and Etoposide in Treating Patients With Relapsed Non-Hodgkin's Lymphoma healthcare trials take place in a lot of of localities throughout the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically assess the effectiveness of new does drugs. The function of the studies / projects is to figure out specific human medical questions. Clinical trials are a popular means for doctors, government agencies, and private sector corporations to find cures for all varieties of conditions, like Etoposide in Treating Patients With Relapsed Non-Hodgkin's Lymphoma. Etoposide in Treating Patients With Relapsed Non-Hodgkin's Lymphoma Clinical Trials and other clinical trials allow volunteers to access health treatment options before they are available to the masses. Many times the subjects receive professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Etoposide in Treating Patients With Relapsed Non-Hodgkin's Lymphoma clinical trial. Human subjects often obtain the finest healthcare possible for their Etoposide in Treating Patients With Relapsed Non-Hodgkin's Lymphoma condition. Hazards are a reality, nevertheless, and might include additional or frequent dr. calls, health hazards (potentially life-jeopardizing), and/or the treatment being uneffective. Trials are federally regulated with stern guidelines to protect clinical trials patients.
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Home > "E" Clinical Trials Conditions > Etoposide in Treating Patients With Relapsed Non-Hodgkin's Lymphoma  Etoposide in Treating Patients With Relapsed Non-Hodgkin's Lymphoma
Etoposide in Treating Patients With Relapsed Non-Hodgkin's Lymphoma
For Condition: Waldenstrom's Macroglobulinemia,recurrent grade III follicular large cell lymphoma,recurrent diffuse small lymphocytic/marginal zone lymphoma,recurrent small lymphocytic lymphoma,recurrent adult diffuse small cleaved cell lymphoma,recurrent adult immunoblastic large cell lymphoma,recurrent grade I follicular small cleaved cell lymphoma,recurrent grade II follicular mixed cell lymphoma,recurrent adult diffuse mixed cell lymphoma,recurrent adult diffuse large cell lymphoma
Status: No longer recruiting
Sponsor(s): National Cancer Institute (NCI) , Cancer and Leukemia Group B
Synopsis: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of etoposide in treating patients with relapsed non-Hodgkin's lymphoma.
Details: OBJECTIVES: I. Evaluate the response rate and response duration in patients with relapsed non-Hodgkin's lymphoma when treated with daily oral etoposide. II. Describe the toxic effects of daily oral etoposide in these patients. III. Monitor etoposide trough levels and determine whether etoposide concentrations correlate with age, response, and toxicity. PROTOCOL OUTLINE: Patients receive oral etoposide daily for 21 days. Treatment is repeated every 28 days in the absence of disease progression or unacceptable toxicity. Patients in complete or partial remission receive 2 courses past best response (minimum 6 courses). Patients with stable disease after 3 courses may be removed from study. Patients are followed every 6 months for 2 years, then annually for survival. PROJECTED ACCRUAL: Approximately 97 patients will be accrued for this study over 2 years.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: /
Genders:
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- - Histologically documented non-Hodgkin's lymphoma; Needle or core biopsy not acceptable as sole means of diagnosis; No mantle cell or transformed lymphoma - One of the following International Working Formulation (IWF) histologic subtypes required: Small lymphocytic with absolute lymphocytic count less than 5,000 (IWF A); Follicular, predominately small cleaved cell (IWF B); Follicular, mixed (IWF C); Follicular, large cell (IWF D); Diffuse, small cleaved cell (IWF E); Diffuse, mixed (IWF F); Diffuse, large cell (IWF G); Large cell, immunoblastic (IWF H) - Recurrent or refractory disease treated with no more than 4 prior chemotherapy regimens; Rebiopsy of a node at first relapse recommended; Prior etoposide (oral or intravenous) allowed if given for no more than 5 days every 3 weeks; The following are considered 1 prior therapy each: Identical drugs given on 2 different schedules Bone marrow transplant preparative regimen (single cycle of chemotherapy used solely to mobilize peripheral blood stem cells considered part of preparative regimen) - Ineligible for protocol CLB-9551 (aminocamptothecin) - Measurable disease by physical exam or imaging study required; Indicator lesion larger than 1 x 1 cm; No prior radiotherapy to indicator lesion unless progression clearly documented The following are not considered measurable: Barium study; Ascites or pleural effusions; Bony disease; Bone marrow involvement - No known parenchymal or leptomeningeal CNS disease; Lumbar puncture not required prior to study --Prior/Concurrent Therapy-- - Biologic therapy: Not specified - Chemotherapy: See Disease Characteristics; At least 3 weeks since prior chemotherapy (3 weeks for nitrosoureas, melphalan, or mitomycin) - Endocrine therapy: No concurrent corticosteroids except for physiologic replacement - Radiotherapy: At least 3 weeks since prior radiotherapy - Surgery: Not specified - Other: No other concurrent investigational agent --Patient Characteristics-- - Age: Not specified - Performance status: CALGB 0-2 - Hematopoietic: Absolute granulocyte count at least 1,500/mm3; Platelet count at least 100,000/mm3 - Hepatic: Bilirubin no greater than 1.5 times normal - Renal: Creatinine no greater than 1.5 times normal - Other: HIV negative (testing required for patients at risk); No uncontrolled infection; No other serious medical condition that would interfere with evaluation of study agent; No psychiatric condition that would preclude protocol completion or informed consent; No second malignancy within 5 years except curatively treated: Basal cell skin cancer; Cervical cancer; Not pregnant or nursing; Adequate contraception required of fertile patients
Total Enrollment:
Location and Contact Information:
Overall Study Official:
NancyBartlett, Study Chair, Cancer and Leukemia Group B
University of Minnesota Cancer Center
Minneapolis, Minnesota, 55455
United States
Washington University Barnard Cancer Center
St. Louis, Missouri, 63110
United States
St. Joseph's Hospital and Medical Center
Paterson, New Jersey, 07503
United States
Comprehensive Cancer Center of Wake Forest University Baptist Medical Center
Winston Salem, North Carolina, 27157-1082
United States
Additional Information:
Study ID Numbers: CDR0000065180; CLB-9650
Study Start Date: November 1996
Record last reviewed: May 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002880
Other Recurrent Small Lymphocytic Lymphoma Studies:
1. Radiolabeled Monoclonal Antibody Plus Rituximab With and Without Filgrastim and Interleukin-11 in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
2. Rituximab and Interleukin-2 in Treating Patients With Low-Grade or Follicular Non-Hodgkin's Lymphoma That is Refractory to Rituximab
3. Combination Chemotherapy and Radiation Therapy Plus Bone Marrow Transplantation in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
4. Etoposide in Treating Patients With Relapsed Non-Hodgkin's Lymphoma
5. Monoclonal Antibody Therapy in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
Related Studies:
Other recurrent small lymphocytic lymphoma Clinical Trials
Other Missouri Clinical Trials
Other St. Louis Clinical Trials
Etoposide in Treating Patients With Relapsed Non-Hodgkin's Lymphoma
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