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Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for qualified medical advice, visits or professional assistance by using a real mD. We are not docs. Always confer with your physician about Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer Clinical research trials and Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer health trials occur in many of cities throughout the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the effectivity of new does drugs. The intent of the studies / undertakings is to resolve particular human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to detect remedies for all sorts of conditions, including Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer. Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer Clinical Trials and other clinical trials permit volunteers to obtain healthcare treatment alternatives before they are available to the masses. Most times the participants undergo professional assistance for without cost, and occasionally they are compensated for their time. Occasionally there is a cost for a Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer clinical trial. Test subjects typically receive the most expert healthcare available for their Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer condition. Dangers are a reality, however, and may include more or frequent mD visits, healthcare dangers (perhaps life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
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Home > "E" Clinical Trials Conditions > Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer  Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer
Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer
For Condition: endometrial adenocarcinoma,stage 1 endometrial cancer,stage 2 endometrial cancer
Status: No longer recruiting
Sponsor(s): Gynecologic Oncology Group , National Cancer Institute (NCI),Eastern Cooperative Oncology Group,Southwest Oncology Group
Synopsis: RATIONALE: Estrogen replacement therapy may improve quality-of-life in postmenopausal women with endometrial cancer. It is not yet known whether estrogen replacement therapy will affect cancer recurrence. PURPOSE: Randomized double-blinded phase III trial to determine the effectiveness of estrogen replacement therapy in treating women who have stage I or stage II endometrial cancer.
Details: OBJECTIVES: - Determine the effect of estrogen replacement therapy on recurrence free and overall survival in women with a history of stage I or II endometrial adenocarcinoma. OUTLINE: This is a randomized, double blind study. Patients are stratified according to stage of endometrial cancer (IA vs IB/IC vs II). Patients are randomized to one of two treatment arms: - Arm I: Patients receive oral conjugated estrogens (Premarin) daily for 3 years. - Arm II: Patients receive oral placebo daily for 3 years. Patients are followed every 6 months for 3 years and then annually for 2 years. PROJECTED ACCRUAL: Approximately 2,108 patients will be accrued for this study.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically confirmed grade I, II or III endometrial adenocarcinoma (endometrioid, villoglandular, mucinous, adenosquamous, papillary serous, clear cell, or not otherwise specified) - Must have had total hysterectomy and bilateral salpingo-oophorectomy within past 20 weeks - Surgical stage IA, IB, IC, IIA (occult), or IIB (occult) disease - Must have had normal mammogram, or a negative breast biopsy after an abnormal mammogram, within past year PATIENT CHARACTERISTICS: Age: - Not specified Performance status: - Not specified Life expectancy: - Not specified Hematopoietic: - Not specified Hepatic: - Bilirubin no greater than 1.5 times normal - SGOT no greater than 3 times normal - No acute liver disease Renal: - Not specified Cardiovascular: - No prior thromboembolic disease Other: - No prior or current carcinoma of the breast - No other prior invasive malignancy within the past 5 years except nonmelanoma skin cancer PRIOR CONCURRENT THERAPY: Biologic therapy: - Not specified Chemotherapy: - Not specified Endocrine therapy: - No concurrent hormonal therapy Radiotherapy: - Not specified Surgery: - See Disease Characteristics - Recovered from prior surgery Other: - No prior cancer treatment that would preclude study therapy - Concurrent participation on GOG Lap-1 or GOG Lap-2 allowed
Total Enrollment:
Location and Contact Information:
Overall Study Official:
RichardBarakat, Study Chair, Memorial Sloan-Kettering Cancer Center
CCOP - Southeast Cancer Control Consortium
Winston Salem, North Carolina, 27104-4241
United States
Good Samaritan Hospital Comprehensive Cancer Center
Portland, Oregon, 97210
United States
Veterans Affairs Medical Center - Temple
Temple, Texas, 76504
United States
Veterans Affairs Medical Center - West Los Angeles
Los Angeles, California, 90073
United States
Brooke Army Medical Center
Fort Sam Houston, Texas, 78234-6200
United States
Oklahoma Medical Research Foundation
Oklahoma City, Oklahoma, 73104
United States
CCOP - St. Louis-Cape Girardeau
St. Louis, Missouri, 63141
United States
Veterans Affairs Medical Center - Chicago (Westside Hospital)
Chicago, Illinois, 60612
United States
CCOP - Greenville
Greenville, South Carolina, 29615
United States
CCOP - Missouri Valley Cancer Consortium
Omaha, Nebraska, 68106
United States
Veterans Affairs Medical Center - Albuquerque
Albuquerque, New Mexico, 87108-5138
United States
CCOP - Santa Rosa Memorial Hospital
Santa Rosa, California, 95403
United States
Veterans Affairs Medical Center - Oklahoma City
Oklahoma City, Oklahoma, 73104
United States
Dwight David Eisenhower Army Medical Center
Fort Gordon, Georgia, 30905-5650
United States
Memorial Sloan-Kettering Cancer Center
New York City, New York, 10021
United States
Veterans Affairs Medical Center - Denver
Denver, Colorado, 80220
United States
Barrett Cancer Center
Cincinnati, Ohio, 45267-0501
United States
Ireland Cancer Center
Cleveland, Ohio, 44106
United States
University of California Davis Medical Center
Sacramento, California, 95817
United States
University of Colorado Cancer Center
Denver, Colorado, 80010
United States
Covenant Health System
Lubbock, Texas, 79410
United States
CCOP - Virginia Mason Research Center
Seattle, Washington, 98101
United States
MBCCOP-Howard University Cancer Center
Washington D.C., District of Columbia, 20060
United States
University of Alabama at Birmingham Comprehensive Cancer Center
Birmingham, Alabama, 35294-3300
United States
David Grant Medical Center
Travis Air Force Base, California, 94535
United States
Duke Comprehensive Cancer Center
Durham, North Carolina, 27710
United States
Community Hospital of Los Gatos
Los Gatos, California, 95032
United States
University of Rochester Medical Center
Rochester, New York, 14642
United States
Cancer Research Center of Hawaii
Honolulu, Hawaii, 96813-2424
United States
Veterans Affairs Medical Center - Kansas City
Kansas City, Missouri, 64128
United States
Arizona Cancer Center
Tucson, Arizona, 85724
United States
Veterans Affairs Outpatient Clinic - Martinez
Martinez, California, 94553
United States
University of Tennessee Medical Center at Knoxville
Knoxville, Tennessee, 37920
United States
University of Texas Medical Branch
Galveston, Texas, 77555-0587
United States
MBCCOP - Gulf Coast
Mobile, Alabama, 36688
United States
Huntsman Cancer Institute
Salt Lake City, Utah, 84112-5550
United States
CCOP - Kansas City
Kansas City, Missouri, 64131
United States
Veterans Affairs Medical Center - Dayton
Dayton, Ohio, 45428
United States
CCOP - Montana Cancer Consortium
Billings, Montana, 59101
United States
State University of New York Health Science Center at Brooklyn
Brooklyn, New York, 11203
United States
Loyola University Medical Center
Maywood, Illinois, 60153
United States
Arthur G. James Cancer Hospital - Ohio State University
Columbus, Ohio, 43210-1240
United States
Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242-1009
United States
CCOP - Duluth
Duluth, Minnesota, 55805
United States
Cancer Center of Albany Medical Center
Albany, New York, 12208
United States
CCOP - Central Illinois
Decatur, Illinois, 62526
United States
CCOP - Ann Arbor Regional
Ann Arbor, Michigan, 48106
United States
Veterans Affairs Medical Center - Charleston
Charleston, South Carolina, 29401-5799
United States
Boston Medical Center
Boston, Massachusetts, 02118
United States
Veterans Affairs Medical Center - Cincinnati
Cincinnati, Ohio, 45220-2288
United States
Veterans Affairs Medical Center - Lexington
Lexington, Kentucky, 40502-2236
United States
Comprehensive Cancer Center at Wake Forest University
Winston Salem, North Carolina, 27157-1065
United States
Brookview Research, Inc.
Nashville, Tennessee, 37203
United States
Louisiana State University Health Sciences Center - Shreveport
Shreveport, Louisiana, 71130-3932
United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109-0912
United States
Ellis Fischel Cancer Center - Columbia
Columbia, Missouri, 65203
United States
CCOP - Kalamazoo
Kalamazoo, Michigan, 49007-3731
United States
Ochsner Clinic
New Orleans, Louisiana, 70121
United States
MBCCOP - LSU Health Sciences Center
New Orleans, Louisiana, 70112
United States
Massey Cancer Center
Richmond, Virginia, 23298-0037
United States
Tripler Army Medical Center
Honolulu, Hawaii, 96859-5000
United States
CCOP - Cancer Research for the Ozarks
Springfield, Missouri, 65807
United States
St. Louis University Health Sciences Center
St. Louis, Missouri, 63110
United States
Veterans Affairs Medical Center - Wichita
Wichita, Kansas, 67218
United States
CCOP - Iowa Oncology Research Association
Des Moines, Iowa, 50309-1016
United States
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, 33612-9497
United States
CCOP - Beaumont
Royal Oak, Michigan, 48073-6769
United States
CCOP - MainLine Health
Wynnewood, Pennsylvania, 19096
United States
Department of OB-GYN
St. Louis, Missouri, 63117
United States
Cooper Hospital/University Medical Center
Camden, New Jersey, 08103-1489
United States
Veterans Affairs Medical Center - Biloxi
Biloxi, Mississippi, 39531-2410
United States
Veterans Affairs Medical Center - Shreveport
Shreveport, Louisiana, 71130
United States
Veterans Affairs Medical Center - Portland
Portland, Oregon, 97207
United States
CCOP - Atlanta Regional
Atlanta, Georgia, 30342-1701
United States
Medical College of Georgia Comprehensive Cancer Center
Savannah, Georgia, 31403-3089
United States
Veterans Affairs Medical Center - Phoenix (Carl T. Hayden)
Phoenix, Arizona, 85012
United States
Veterans Affairs Medical Center - Boston (Jamaica Plain)
Jamaica Plain, Massachusetts, 02130
United States
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, 44195-9001
United States
Veterans Affairs Medical Center - Detroit
Detroit, Michigan, 48201-1932
United States
Crouse Hospital
Syracuse, New York, 13210
United States
University of Mississippi Medical Center
Jackson, Mississippi, 39216-4505
United States
Walter Reed Army Medical Center
Washington D.C., District of Columbia, 20307-5001
United States
Washington University School of Medicine
St. Louis, Missouri, 63110
United States
Swedish Cancer Institute
Seattle, Washington, 98104
United States
Butterworth Hospital
Grand Rapids, Michigan, 49503
United States
Veterans Affairs Medical Center - Ann Arbor
Ann Arbor, Michigan, 48105
United States
CCOP - Scott and White Hospital
Temple, Texas, 76508
United States
Veterans Affairs Medical Center - Seattle
Seattle, Washington, 98108
United States
Providence Hospital - Southfield
Southfield, Michigan, 48075-9975
United States
CCOP - Dayton
Kettering, Ohio, 45429
United States
Veterans Affairs Medical Center - Jackson
Jackson, Mississippi, 39216
United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111
United States
OHSU Cancer Institute
Portland, Oregon, 97239
United States
Fletcher Allen Health Care - Medical Center Campus
Burlington, Vermont, 05401
United States
Herbert Irving Comprehensive Cancer Center
New York City, New York, 10032
United States
Veterans Affairs Medical Center - Salt Lake City
Salt Lake City, Utah, 84148
United States
CCOP - Columbus
Columbus, Ohio, 43206
United States
Morristown Memorial Hospital
Morristown, New Jersey, 07962-1956
United States
Tampa Bay Cancer Consortium
Saint Petersburg, Florida, 33701
United States
Veterans Affairs Medical Center - San Antonio (Murphy)
San Antonio, Texas, 78284
United States
Southern Pines Women's Health Center
Southern Pines, North Carolina, 28388-0749
United States
Madigan Army Medical Center
Tacoma, Washington, 98431-5000
United States
University of Chicago Cancer Research Center
Chicago, Illinois, 60637-1470
United States
Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital)
Hines, Illinois, 60141
United States
MBCCOP - University of New Mexico HSC
Albuquerque, New Mexico, 87131
United States
Abington Memorial Hospital
Abington, Pennsylvania, 19001-3788
United States
Baptist Regional Cancer Center - Knoxville
Knoxville, Tennessee, 37901
United States
Lineberger Comprehensive Cancer Center, UNC
Chapel Hill, North Carolina, 27599-7295
United States
Albert B. Chandler Medical Center, University of Kentucky
Lexington, Kentucky, 40536-0084
United States
Medical University of South Carolina
Charleston, South Carolina, 29425-0721
United States
MBCCOP - University of Illinois at Chicago
Chicago, Illinois, 60612-7323
United States
City of Hope Comprehensive Cancer Center
Duarte, California, 91010
United States
Earl K. Long Medical Center
Baton Rouge, Louisiana, 70805
United States
CCOP - Carle Cancer Center
Urbana, Illinois, 61801
United States
CCOP - Northwest
Tacoma, Washington, 98405-0986
United States
CCOP - Grand Rapids Clinical Oncology Program
Grand Rapids, Michigan, 49503
United States
Cancer Center at the University of Virginia
Charlottesville, Virginia, 22908
United States
Veterans Affairs Medical Center - Tucson
Tucson, Arizona, 85723
United States
State University of New York Health Sciences Center - Stony Brook
Stony Brook, New York, 11794-8091
United States
University of Virginia at Roanoke
Roanoke, Virginia, 24013
United States
Indiana University Cancer Center
Indianapolis, Indiana, 46202-5289
United States
Tulane University School of Medicine
New Orleans, Louisiana, 70112
United States
CCOP - Bay Area Tumor Institute
Oakland, California, 94609-3305
United States
Robert H. Lurie Comprehensive Cancer Center, Northwestern University
Chicago, Illinois, 60611-3013
United States
University of Minnesota Cancer Center
Minneapolis, Minnesota, 55455
United States
Henry Ford Hospital
Detroit, Michigan, 48202
United States
Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109-1024
United States
CCOP - M.D. Anderson Research Base
Houston, Texas, 77030-4009
United States
CCOP - St. Vincent Hospital Cancer Center, Green Bay
Green Bay, Wisconsin, 54301
United States
Veterans Affairs Medical Center - Little Rock (McClellan)
Little Rock, Arkansas, 72205
United States
CCOP - Sioux Community Cancer Consortium
Sioux Falls, South Dakota, 57104
United States
CCOP - Greater Phoenix
Phoenix, Arizona, 85006-2726
United States
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, 90095-1781
United States
CCOP - Upstate Carolina
Spartanburg, South Carolina, 29303
United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
United States
USC/Norris Comprehensive Cancer Center and Hospital
Los Angeles, California, 90033-0804
United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78284-7845
United States
Sacred Heart Hospital of Pensacola
Pensacola, Florida, 32504
United States
University of Kansas Medical Center
Kansas City, Kansas, 66160-7390
United States
Keesler Medical Center - Keesler AFB
Keesler AFB, Mississippi, 39534-2576
United States
CCOP - Wichita
Wichita, Kansas, 67214-3882
United States
University of Oklahoma College of Medicine
Oklahoma City, Oklahoma, 73190
United States
Methodist Cancer Center - Omaha
Omaha, Nebraska, 68114
United States
CCOP - Columbia River Program
Portland, Oregon, 97225
United States
Chao Family Comprehensive Cancer Center
Orange, California, 92868
United States
Eastern Virginia Medical School
Norfolk, Virginia, 23510-1115
United States
University of Tennessee Cancer Institute
Winston Salem, North Carolina, 27157-1065
United States
Mayo Clinic
Jacksonville, Florida, 32224
United States
Additional Information:
Study ID Numbers: CDR0000065498; GOG-137A,E-G0137,SWOG-G0137
Study Start Date:
Record last reviewed: April 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002976
Other Stage 1 Endometrial Cancer Studies:
1. Quality of Life in Survivors of Gynecologic Cancer
2. Radiation Therapy With or Without Chemotherapy in Treating Patients With High-Risk Endometrial Cancer
3. Laparoscopic Surgery or Standard Surgery in Treating Patients With Endometrial Cancer or Cancer of the Uterus
4. Surgery With or Without Lymphadenectomy and Radiation Therapy in Treating Patients With Endometrial Cancer
5. Radiation Therapy or No Further Treatment Following Surgery in Treating Patients With Stage I Endometrial Cancer
Related Studies:
Other stage 1 endometrial cancer Clinical Trials
Other Oklahoma Clinical Trials
Other Oklahoma City Clinical Trials
Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer
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