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Estrogen Modulation of Mood and Cognition Following Monoaminergic Depletion in Post-Menopausal Women



Estrogen Modulation of Mood and Cognition Following Monoaminergic Depletion in Post-Menopausal Women

For Condition: Menopause
Status: Recruiting
Sponsor(s): National Center for Research Resources (NCRR) ,
Synopsis: This study will examine whether estrogen administration in postmenopausal women can alter the response to changes in brain chemistry brought about by dietary manipulation. Women who are recently menopausal (50-60 yrs. of age) and over 20 years postmenopausal (>70 yrs. of age) will take estrogen or placebo for three months. At the end of that time they will participate in three challenges using dietary techniques to briefly change the relative amounts of neurotransmitters in the brain that are believed to be related to mood regulation (serotonin, dopamine, and norepinephrine). Previous research has shown that these dietary manipulations can briefly produce negative changes in mood. The investigator hypothesizes that estrogen administration will blunt or buffer these negative effects in a quantifiable way. The investigator believes that this will provide a direct test of the ability of estrogen to meaningfully change the brain chemistry of mood in a clinically measurable and positive way. The proposed procedure will also allow assessment of the effects of estrogen on brain neurotransmitter systems after many years of very low estrogen levels.
Details:
Eligibility:
Study Type:
  Interventional, Treatment, Randomized, Double-Blind
Minimum Age/Maximum Age: 50 Years/
Genders: Female
Protocol Entry Criteria: Inclusion Criteria: - postmenopausal - nonsmoker - BMI <30 - healthy - without surgically-induced menopause - not on HRT or >1 year post HRT - normal mammogram within last year - no cardiovascular disease other than mild hypertension
Total Enrollment: 

Location and Contact Information:

University of Vermont *Recruiting*
Burlington,  Vermont,  05401
United States
Recruiting Paul  Newhouse 802-847-4560


Additional Information:
Study ID Numbers:
  NCRR-M01RR00109-0741;  M01RR00109
Study Start Date: 
Record last reviewed: December 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005768

Other Menopause Studies:
1. Alternative Therapies for Menopause: A Randomized Trial

2. Nurses' Health Study

3. Use of Black Cohosh and Red Clover for the Relief of Menopausal Symptoms

4. Women's Healthy Lifestyle Project: Cardiovascular Risk Factors and Menopause

5. Development and Evaluation of a Hormone Replacement Therapy Decision-Aid

Related Studies:

Other Menopause Clinical Trials
Other Vermont Clinical Trials
Other Burlington Clinical Trials

Estrogen Modulation of Mood and Cognition Following Monoaminergic Depletion in Post-Menopausal Women

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