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Home > "E" Clinical Trials Conditions > Establishment of Normal Breast Epithelial Cell Lines from Patients at High Risk for Breast Cancer  Establishment of Normal Breast Epithelial Cell Lines from Patients at High Risk for Breast Cancer
Establishment of Normal Breast Epithelial Cell Lines from Patients at High Risk for Breast Cancer
For Condition: Breast Neoplasm,Hereditary Neoplastic Syndrome
Status: Completed
Sponsor(s): National Cancer Institute (NCI) ,
Synopsis: Women who are at high risk for breast cancer, either because of linkage to high risk breast and ovarian cancer families, or because of a carcinoma in the opposite breast, will be studied. Women will have a physical examination and mammography to ensure that no breast abnormalities are present. Eligible women will undergo biopsy of the breast to obtain normal breast tissue. Short-term cell cultures will be established from this tissue and early passages of the short-term cell lines will be stored. A bank of high risk normal mammary epithelial cells will be established. To further characterize the mammary epithelial cells in this population of women, cell cultures will subsequently be analyzed for their growth and metabolic properties, sensitivity to chemopreventive agents, steroid receptor characteristics, oncogene expression and regulation, and genetic changes.
Details: Women who are at high risk for breast cancer, either because of linkage to high risk breast and ovarian cancer families, or because of a carcinoma in the opposite breast, will be studied. Women will have a physical examination and mammography to ensure that no breast abnormalities are present. Eligible women will undergo biopsy of the breast to obtain normal breast tissue. Short-term cell cultures will be established from this tissue and early passages of the short-term cell lines will be stored. A bank of high risk normal mammary epithelial cells will be established. To further characterize the mammary epithelial cells in this population of women, cell cultures will subsequently be analyzed for their growth and metabolic properties, sensitivity to chemopreventive agents, steroid receptor characteristics, oncogene expression and regulation, and genetic changes.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Women at high risk for breast cancer, either because they are a member of a high risk breast or ovarian cancer family, or because of a carcinoma of the opposite breast. Normal mammogram within past 3 months. No suspicious breast or axillary lesions on physical examination. No major cardiopulmonary, hepatic or renal disorders.
Total Enrollment: 50
Location and Contact Information:
National Cancer Institute (NCI)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 960026; 96-C-0026
Study Start Date: January 19, 1996
Record last reviewed: November 20, 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001496
Other Breast Neoplasm Studies:
1. A Prospective Study to Evaluate Potential Factors Affecting Weight Among Breast Cancer Patients Receiving Adjuvant Chemotherapy
2. Autologous T-Cell Transplantation and the Immunotherapy of Residual Disease in Breast Cancer: Pilot Study of Vaccine-Driven T-Cell Expansion in Patients Treated with Dose-Intensive Chemotherapy
3. Phase I Study of LMB-9, a Recombinant Disulfide Stabilized Immunotoxin for Advanced Carcinomas that Express Lewis Y Antigen
4. Breast Imaging Studies in Women at High Genetic Risk of Breast Cancer: Annual Follow-Up Study
5. Methods in Education for Breast Cancer Genetics
Related Studies:
Other Breast Neoplasm Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Establishment of Normal Breast Epithelial Cell Lines from Patients at High Risk for Breast Cancer
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