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Home > "E" Clinical Trials Conditions > Epidemiology of Carotid Artery Atherosclerosis in Youth  Epidemiology of Carotid Artery Atherosclerosis in Youth
Epidemiology of Carotid Artery Atherosclerosis in Youth
For Condition: Heart Diseases,Carotid Artery Diseases,Cardiovascular Diseases,Atherosclerosis
Status: No longer recruiting
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: To examine the relationship of risk factors measured in childhood to intimal medial thickness (IMT) in early adulthood and to examine familial factors which may be related to increased IMT, a measure of atherosclerosis.
Details: BACKGROUND: The atherosclerotic process begins in childhood and advances through adult life when occlusive vascular disease results in coronary heart disease, stroke and peripheral vascular disease. Although risk factors have been established in adult populations, risk factors when measured in childhood have not been directly related to morbidity and mortality from occlusive atherosclerotic disease. The ultrasonographic measurement of carotid artery intimal-medial thickness (IMT) in adults is related not only to the risk for stroke but also to the severity of atherosclerotic disease in the coronary arteries. In 1970, a population of school age children and adolescents was first examined in Muscatine, Iowa, and since then has been followed to examine the predictive value of childhood risk factor levels for cardiovascular disease. See also Study 906 (Muscatine Heart Study). The study will provide a view of the significance of IMT in young adults not only in its relationship to risk factors in childhood and young adulthood but also to familial factors that may be responsible for accelerated atherosclerosis. DESIGN NARRATIVE: Beginning in 1995, the longitudinal study examined the following: 1) the relationship of body mass index (BMI), blood pressure, total cholesterol, and smoking behaviors measured in childhood to IMT measured in early adulthood; 2) the relationship of risk factors (BMI, blood pressure, total cholesterol, LDL-C, HDL-C, Apo A1, Apo B, Lp(a), Apo E genotypes, glucose insulin and smoking) to IMT in young adults; 3) the relationship of risk factor 'load' from childhood to adult life to IMT; 4) the relationship of IMT in young adults to familial mortality in first- and second-degree relatives due to vascular disease; and 5) the degree of familial aggregation of IMT in young adults and their parents. The study was renewed in FY 2000 to investigate the third generation of the Muscatine Heart Study cohort. The renewal will determine whether the offspring of cohort members with premature atherosclerosis or a familial history of cardiovascular disease have increased carotid intimal-medial thickness (IMT) or elevated risk factors, identify risk factors for progression of carotid IMT, and measure putative riskfactors for increased IMT (serologic evidence of Clamydia pneumoniae or cytomegalovirus infection, high sensitivity C-reactive protein, fibrinogen, plasminogen activator inhibitor-1 and glycosylated hemoglobin).
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Male
Protocol Entry Criteria: No eligibility criteria
Total Enrollment:
Location and Contact Information:
Overall Study Official:
PatriciaDavis, , University of Iowa
Additional Information:
Study ID Numbers: 4305;
Study Start Date: September 1995
Record last reviewed: February 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005397
Other Cardiovascular Diseases Studies:
1. Antioxidants and Prevention of Early Atherosclerosis
2. Epidemiology of Carotid Disease in Elderly Adults
3. Carotid Atherosclerosis Follow-up Study
4. Epidemiology of Carotid Artery Atherosclerosis in Youth
5. Strong Heart Study
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Epidemiology of Carotid Artery Atherosclerosis in Youth
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