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Electrophysiologic Measures of Treatment Response in Alzheimer Disease



Electrophysiologic Measures of Treatment Response in Alzheimer Disease

For Condition: Alzheimer Disease
Status: Recruiting
Sponsor(s): Department of Veterans Affairs Medical Research Service ,
Synopsis: The main purpose of this study is to determine the electrophysiological effects of cholinergic therapy (cholinesterase inhibitors and transdermal nicotine) in Alzheimer disease. The attempt will be to locate electrophysiological markers and predictors of cognitive and clinical treatment response.
Details:
Eligibility:
Study Type:  Interventional, Treatment, Non-Randomized, Open Label, Uncontrolled, Crossover Assignment, Efficacy Study
Minimum Age/Maximum Age: 55 Years/85 Years
Genders: Both
Protocol Entry Criteria: Patients diagnosed with mild to moderate probable Alzheimer's disease (mini-mental state exam scores between 15-27), and normal controls (age generally between 60-85). Subjects must either be planning to start daily cholinesterase therapy (e.g. Aricept, Exelon) or willing to try a transdermal nicotine patch for two 8 hour periods.
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
ShuannaMorris,  , 

Department of Veterans Affairs *Recruiting*
San Diego,  California,  92161
United States
Recruiting Shaunna  Morris 858-552-8585


Additional Information:
Study ID Numbers:  AGCG-004-98S; 
Study Start Date: October 1998
Record last reviewed: June 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00018278

Other Alzheimer Disease Studies:
1. Study of Aripiprazole in the Treatment of Patients with Psychosis Associated with Dementia of the Alzheimer's Type

2. Antigonadotropin-Leuprolide in Alzheimer's Disease Drug INvestigation (ALADDIN) VP 104 Study

3. Memory Impairment Study (Mild Cognitive Impairment Study)

4. The Depression in Alzheimer's Disease Study (DIADS)

5. Evaluation Of Three Doses of NS 2330 in Patients with Mild to Moderate Dementia of the Alzheimer’s Type

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Electrophysiologic Measures of Treatment Response in Alzheimer Disease
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