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Efficacy and Safety of Azimilide for the Treatment of Patients With Atrial Fibrillation Clinical Trials Info presented on Clinical Trials Search is not intended to be a substitute for certified medical advice, visits or professional assistance using a real physician. We are not physicians. Always consult your dr. about Efficacy and Safety of Azimilide for the Treatment of Patients With Atrial Fibrillation conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Efficacy and Safety of Azimilide for the Treatment of Patients With Atrial Fibrillation Clinical research trials and Efficacy and Safety of Azimilide for the Treatment of Patients With Atrial Fibrillation health trials happen in many of localities throughout the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new drugs. The function of the studies / projects is to resolve particular human medical questions. Clinical trials are a popular manner for mDs, government agencies, and private sector corporations to discover remedies for all varieties of circumstances, like Efficacy and Safety of Azimilide for the Treatment of Patients With Atrial Fibrillation. Efficacy and Safety of Azimilide for the Treatment of Patients With Atrial Fibrillation Clinical Trials and other clinical trials allow volunteers to obtain healthcare treatment options before they are available to the masses. Some times the participants undergo professional assistance for free of charge, and occasionally they are paid for their time. Sometimes there is a cost for a Efficacy and Safety of Azimilide for the Treatment of Patients With Atrial Fibrillation clinical trial. Human subjects often get the best healthcare available for their Efficacy and Safety of Azimilide for the Treatment of Patients With Atrial Fibrillation condition. Dangers are a reality, however, and may include additional or frequent mD visits, healthcare dangers (potentially life-jeopardising), and/or the treatment being ineffectual. Trials are federally governed with rigorous guidelines to protect clinical trials patients.
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Home > "E" Clinical Trials Conditions > Efficacy and Safety of Azimilide for the Treatment of Patients With Atrial Fibrillation  Efficacy and Safety of Azimilide for the Treatment of Patients With Atrial Fibrillation
Efficacy and Safety of Azimilide for the Treatment of Patients With Atrial Fibrillation
For Condition: Atrial Fibrillation
Status: Completed
Sponsor(s): Procter & Gamble Pharmaceuticals ,
Synopsis: Atrial fibrillation (abnormal rhythm in the upper chamber of the heart) is a common supraventricular arrhythmia (abnormal heart rhythm) for which antiarrhythmic therapy is often prescribed. The primary goals of therapy are to maintain sinus rhythm (normal heart rhythm) and to reduce the occurrence of episodes of atrial fibrillation. Azimilide may have an effect on increasing the time to first recurrence of symptomatic atrial fibrillation or atrial flutter and symptomatic paroxysmal supraventricular tachycardia (other types of abnormal heart rhythms). This double-blind, placebo-controlled study is designed to evaluate the efficacy and safety of azimilide compared with placebo in maintaining sinus rhythm in patients who require cardioversion (electric shock to correct heart rhythm) to reduce atrial fibrillation. Once this phase of the study is completed, a second phase with a different study design will be conducted. The second phase is an open-label follow-up phase to the study. This follow-up phase will continue to evaluate the long-term efficacy and safety of a daily oral dose of azimilide in patients who complete the double-blind, placebo-controlled phase of this study.
Details:
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study
Minimum Age/Maximum Age: 18 Years/80 Years
Genders: Both
Protocol Entry Criteria: Inclusion criteria: - Documented (12-lead ECG) history of symptomatic atrial fibrillation occurring between 48 hours and 6 months before screening - Require the procedure of cardioversion (electric shock to correct heart rhythm) - In the investigator's opinion, be likely to maintain sinus rhythm after cardioversion. - Be anticoagulated according to the recommendations of the Study Group on Atrial Fibrillation of the European Society of Cardiology guidelines. Exclusion criteria: - Previously unsuccessful electrical cardioversions - Failed to respond to any Class III antiarrhythmic drugs - Qualifying arrhythmia due to acute reversible illness, acute myocardial infarction, and/or cardiac or thoracic surgery within one month prior to randomization
Total Enrollment: 440
Location and Contact Information:
VA Medical Center Therapeutic Section
Minneapolis, Minnesota, 55417
United States
Cardiovascular Associates of Penisula
Burlingame, California, 94010
United States
Recherche Cardiologie
Montreal, Quebec, H2L4M1
Canada
University Medical Center
Tucson, Arizona, 85742
United States
FHS Research
Tacoma, Washington, 98405
United States
Duke Medical Center
Durham, North Carolina, 27710
United States
Cardiology Section, West Los Angeles VA Hospital
Los Angeles, California, 90073
United States
Heart Center Medical Group
Ft. Wayne, Indiana, 46804
United States
LAC + USC Medical Center
Los Angeles, California, 90033
United States
St. Michael's Hospital
Toronto, Ontario, M5B 1W8
Canada
VA Medical Center
Decatur, Georgia, 30033
United States
Cardiology Associates
San Diego, California, 92120
United States
The Pavillion
Jenkintown, Pennsylvania, 19046
United States
Altru Health System Research Center
Grand Forks, North Dakota, 58201
United States
Heart and Vascular Inst. of Texas, PA
San Antonio, Texas, 78217
United States
ARI Clinical Trials
Redondo Beach, California, 90277
United States
Good Samaritan Hospital
Los Angeles, California, 90017
United States
Androscoggin Cardiology Associates Research
Auburn, Maine, 04201
United States
Charleston Cardiology
Charleston, South Carolina, 29403
United States
Lakeland Regional Medical
Lakeland, Florida, 33805
United States
Hospital Sacre-Coeur de Montreal
Montreal, Quebec, H4J1C5
Canada
Elgin Cardiology Associates
Elgin, Illinois, 60120
United States
University of Louisville-Cardiology
Louisville, Kentucky, 40202
United States
The Care Group
Indianapolis, Indiana, 46260
United States
Cardiovascular Institute of the South
Houma, Louisiana, 70360
United States
Wisconsin Center for Clinical Research
Elkhorn, Wisconsin, 53121
United States
Lindner Clinical Trial Ctr.
Cincinnati, Ohio, 45219
United States
Heart Care Group PC
Allentown, Pennsylvania, 18106
United States
The George Washington University MFA
Washington D.C., District of Columbia, 20037
United States
Methodist Hospital
Houston, Texas, 77030
United States
Florida Cardiology
Orlando, Florida, 32803
United States
La Mesa Cardiac Center, a Medical Group
La Mesa, California, 91942
United States
Rockyview General Hospital CV Lab Research
Calgary, Alberta, T2V 1P9
Canada
Riverside Regional Medical Center
Newport News, Virginia, 23601
United States
C/O Research Office Attn: Cardiovascular Research Dept.
Ft. Lauderdale, Florida, 33316
United States
Hartford Hospital
Hartford, Connecticut, 06102
United States
Wisconsin Center for Clinical Research
Milwaukee, Wisconsin, 53251
United States
Montreal Heart Institute
Montreal, Quebec, H1T1C8
Canada
University Hospitals of Cleveland
Cleveland, Ohio, 44106
United States
San Diego Cardiovascular Research Associates
Encinitas, California, 92024
United States
Merced Heart Associates
Merced, California, 95340
United States
Sutter Gould Medical Foundation
Modesto, California, 95335
United States
Khalid Hasan Sheikh 80 Fortenberry Road
Merritt Island, Florida, 32952
United States
St. Paul Heart Clinic
St. Paul, Minnesota, 55102
United States
University of Ottawa Heart Institute
Ottawa, Ontario, K1Y 4W7
Canada
Richard Gilmore 501 S. Ryan Street
Lake Charles, Louisiana, 70601
United States
Western Cardiology Assoc.
Denver, Colorado, 80218
United States
Cardiology Foundation of Lankenau
Wynnewood, Pennsylvania, 19096
United States
Neureka Research Corporation
Sudbury, Ontario, P3E6B4
Canada
Oregon Health Sciences University
Portland, Oregon, 97201
United States
Dean/Riverview Clinic
Janesville, Wisconsin, 53547
United States
Regional Heart Center
Duluth, Minnesota, 55805
United States
University of Massachusett
Worcester, Massachusetts, 01655
United States
Stern Cardiovascular Center Research Department
Memphis, Tennessee, 38120
United States
Louisville Cardiology Medical Group, P.S.C.
Louisville, Kentucky, 40207
United States
Quebec Heart Institute
Sainte-Foy, Quebec, G1V4G5
Canada
Cardiovascular Instiute of the South
Morgan City, Louisiana, 70380
United States
University of Wisconsin Madison
Madison, Wisconsin, 53792
United States
UT Southwestern Medical Center
Dallas, Texas, 75390
United States
Hamilton Health Sciences Crop
Hamilton, Ontario, L8L 2X2
Canada
Tulane University
New Orleans, Louisiana, 70112
United States
Advocate Christ Medical Center
Oak Lawn, Illinois, 60453
United States
Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033
United States
Cardiac Investigation Unit
London, Ontario, N6A 5A5
Canada
Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216
United States
Inland Clinical Research
Riverside, California, 92501
United States
Hillsboro Cardiology
Hillsboro, Oregon, 97123
United States
UPHS/Presbyterian Medical Center
Philadelphia, Pennsylvania, 19104
United States
Tri-State Medical Group Cardiology
Beaver, Pennsylvania, 15009
United States
Health Sciences Centre
Winnipeg, Manitoba, R3E0Z3
Canada
Regional Cardiology Assoc.
Sacramento, California, 95819
United States
Cardiovascular and Critical Care Associates, P.C.
Pittsburgh, Pennsylvania, 15224
United States
Riverside Osteopathic Hospital
Trenton, Michigan, 48183
United States
Cardiology Consultants
Daytona Beach, Florida, 32114
United States
Beloit Clinic, SC
Beloit, Wisconsin, 53511
United States
Cardiology Research St. Paul's Hospital
Vancouver, British Columbia, V6Z 1Y6
Canada
Daniel Gottlieb 16259 Sylvester Road SW Suite 401
Seattle, Washington, 98166
United States
Thoracic & Cardiovascular Healthcare Foundation
Lansing, Michigan, 48910
United States
University of Calgary
Calgary, Alberta, T2N 4N1
Canada
Maine Medical Center
Portland, Maine, 04102
United States
Cardiology Reasearch Assiocates
Ormond Beach, Florida, 32174
United States
The Heart Group, PC
Mobile, Alabama, 36608
United States
Additional Information:
Study ID Numbers: 2000038;
Study Start Date:
Record last reviewed: May 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00035477
Other Atrial Fibrillation Studies:
1. Epidemiology of Symptomatic Arrhythmias
2. A safety and efficacy trial evaluating the use of SanOrg34006 compared to warfarin or acenocoumarol in patients with atrial fibrillation
3. Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM)
4. Compare the effects of amiodarone, sotalol, and placebo in maintaining sinus rhythm in patients with atrial fibrillation converted to sinus rhythm
5. Efficacy and Safety of Azimilide for the Treatment of Patients With Atrial Fibrillation
Related Studies:
Other Atrial Fibrillation Clinical Trials
Other Quebec Clinical Trials
Other Montreal Clinical Trials
Efficacy and Safety of Azimilide for the Treatment of Patients With Atrial Fibrillation
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