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Home > "E" Clinical Trials Conditions > Effects of Strength Training on Knee Osteoarthritis  Effects of Strength Training on Knee Osteoarthritis
Effects of Strength Training on Knee Osteoarthritis
For Condition: Osteoarthritis, Knee
Status: No longer recruiting
Sponsor(s): National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) ,
Synopsis: To understand the effects of leg strengthening exercise, we will study the effects of strength training of the legs in four groups of people: (1) osteoarthritis (OA) with knee pain; (2) OA without knee pain; (3) no OA but elderly with knee pain; and (4) normal elderly with no OA or knee pain. In each of the first three groups, we will look at whether people who do strength training have less pain and/or slower progression of x-ray signs of OA over 30 months than people who perform nonstrengthening, range-of-motion exercises. We are including the fourth group to find out whether people with OA (groups 1 & 2) have the same response to strength training as healthy elderly people, and whether those with knee pain (groups 1 & 3) have the same response to training as those without joint pain.
Details: Several studies have confirmed that weak leg muscles are associated with osteoarthritis (OA) of the knee. Studies of body composition in these people have also shown that, despite being weaker, people with OA have significantly greater muscle mass than those without OA, suggesting that those with OA may have the potential to greatly increase their strength. However, research has not clearly shown whether exercises designed to improve leg strength will decrease the severity of pain or slow the progression of OA based on radiographic (x-ray) analysis. To understand the effects of leg strengthening exercise, we will perform a randomized clinical trial of lower extremity strength training using four subgroups of people: (1) OA with knee pain; (2) OA without knee pain; (3) no OA with knee pain; and (4) normal elderly with no OA or knee pain. In each of the first three groups, we will determine whether people assigned to strength training have lower pain scores and/or slower progression of radiographic changes of OA over 30 months than controls who perform nonstrengthening exercises (i.e., range-of-motion exercises). We are including the fourth group to determine whether those with OA (groups 1 & 2) exhibit the same response to strength training as healthy elderly people, and whether those with knee pain (groups 1 & 3) have the same response to training as those without joint pain. We will also prospectively monitor changes in body composition and bone mass, quality of life, and symptoms of depression.
Eligibility:
Study Type: Interventional, Treatment, Randomized, Single Blind, Active Control, Single Group Assignment, Efficacy Study
Minimum Age/Maximum Age: 60 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Males and females 60 to 100 years of age Exclusion Criteria: - Knee joint replacement surgery - Diabetes mellitus - Uncontrollable hypertension - Neuropathies of the lower extremity - Poor mental cognition (i.e., inability to follow instructions)
Total Enrollment: 280
Location and Contact Information:
Overall Study Official:
AlanMikesky, Principal Investigator, Indiana University School of Medicine
National Institute for Fitness and Sport
Indianapolis, Indiana, 46202
United States
Additional Information:
Study ID Numbers: NIAMS-022; P60 AR20582,Sub: EEHSR3
Study Start Date: September 1977
Record last reviewed: February 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00000406
Other Osteoarthritis, Knee Studies:
1. Efficacy and Safety of PG-530742 in the treatment of Mild to Moderate Knee Osteoarthritis
2. Cost-effectiveness of and Long-term Outcomes Following Acupuncture Treatment for Osteoarthritis of the Knee
3. Safety of Civamide Cream 0.075% as a Treatment in Subjects with Osteoarthritis of the Knee(s)
4. Shoe Insert Study
5. Effects of Strength Training on Knee Osteoarthritis
Related Studies:
Other Osteoarthritis, Knee Clinical Trials
Other Indiana Clinical Trials
Other Indianapolis Clinical Trials
Effects of Strength Training on Knee Osteoarthritis
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