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Effects of Salt Intake on the Nervous Systems of Patients with Salt-Sensitive High Blood Pressure



Effects of Salt Intake on the Nervous Systems of Patients with Salt-Sensitive High Blood Pressure

For Condition: Hyperaldosteronism,Hypertension
Status: Completed
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: Some patients with high blood pressure can experience an increase of blood pressure by 10 percent or more by taking in salt. These patients are referred to as having "salt-sensitive" (SS) hypertension. Previous studies conducted on patients with salt sensitive hypertension suggest that their portion of the nervous system responsible for maintaining normal blood pressure (autonomic nervous system) may respond differently to salt than patients with non-salt sensitive (NSS) hypertension. This study is designed to examine the response of the nervous system to high doses of salt in patients with salt-sensitive hypertension and patients with non-salt sensitive hypertension.
Details: A subset of patients with idiopathic hypertension shows an increase in blood pressure of 10 percent or more in response to salt-loading and have been termed "salt-sensitive" (SS). Limited studies of adrenergic function in response to salt-loading suggest that the response of SS patients may differ from that of non-salt sensitive (NSS) patients. The present studies were designed to examine the response of the adrenergic and dopaminergic systems to salt-loading in SS and NSS patients with idiopathic hypertension.
Eligibility:
Study Type:
  Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Eligibility criteria not identified in protocol.
Total Enrollment: 110

Location and Contact Information:

National Heart, Lung and Blood Institute (NHLBI)
Bethesda,  Maryland,  20892
United States
 


Additional Information:
Study ID Numbers:
  810081;  81-H-0081
Study Start Date: May 6, 1981
Record last reviewed: December 17, 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001176

Other Hypertension Studies:
1. Pawtucket Heart Health Program

2. White Coat Hypertension and Antihypertensive Treatment Effect - SCOR in Hypertension

3. Hypertension in Minorities Database-Workshop and Publication

4. Diagnosis/Pathophysiology of Glucocorticoid Remediable Aldosteronism Hypertension

5. National Heart, Lung, and Blood Institute Twin Study

Related Studies:

Other Hypertension Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials

Effects of Salt Intake on the Nervous Systems of Patients with Salt-Sensitive High Blood Pressure

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