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Home > "E" Clinical Trials Conditions > Effects of Meditation on Mechanism of Coronary Heart Disease  Effects of Meditation on Mechanism of Coronary Heart Disease
Effects of Meditation on Mechanism of Coronary Heart Disease
For Condition: Coronary Heart Disease
Status: No longer recruiting
Sponsor(s): National Center for Complementary and Alternative Medicine (NCCAM) ,
Synopsis: To study the effects of Transcendental Meditation on Coronary Heart Disease
Details: Recent advances in our understanding of the pathophysiology of acute cardiac events - specifically, identification of the roles that arterial vasomotor dysfunction and autonomic nervous system imbalances play in the pathophysiologic cascade during such acute events - provides a platform for new mechanistic investigation of the interplay of psychosomatic stress and CHD (coronary heart disease). Preliminary evidence further suggests that Complementary and Alternative Medicine (CAM) practices, such as the Transcendental Meditation (TM) technique, can not only reduce stress but also reduce acute cardiac events in patients with CHD. Based on these and related data, we propose a randomized, blinded, controlled study of the effects of one CAM practice, the TM technique, compared to a control group, on the primary outcomes of (1) arterial vasomotor dysfunction (brachial artery reactivity); (2) autonomic nervous system imbalances (heart rate variability); (3) transient myocardial ischemia (ST-segment depression); and (4) the secondary outcomes of psychological stress and quality of life (anger, hostility, anxiety, depression, perceived health, disease-specific symptoms, and life stress/social resources).
Eligibility:
Study Type: Interventional, Treatment, Randomized
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Able to attend training sessions and meetings - Local residence Exclusion Criteria: - Comorbid disease precluding survival in group - MI, unstable angina, CABG or PTCA within last three months. - Cognitive/psychological/substance abuse impairment - Atrial fibrillation, predominant pacemaker rhythm or significant conduction system disease - Significant valvular heart disease - Class III or IV heart failure - Renal failure - Participating in a formal stress management program - Participation in another trial
Total Enrollment:
Location and Contact Information:
Overall Study Official:
C.Bairey Merz, Principal Investigator, Preventive and Rehabilitative Cardiac Center
Preventive and Rehabilitative Cardiac Center
Los Angeles, California,
United States
Additional Information:
Study ID Numbers: 1 R01 AT00226-01M; 1 R01 AT00226-01
Study Start Date:
Record last reviewed: November 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00010738
Other Coronary Heart Disease Studies:
1. Evaluation of the Safety & Efficacy of a Combination of Niacin ER & Simvastatin in Patients with Dyslipidemia (OCEANS)
2. Comparative Efficacy Evaluation of Lipids when Treated with Niaspan & Statin or Other Lipid-Modifying Therapies-COMPELL
3. Effects of Meditation on Mechanism of Coronary Heart Disease
4. From Research to Practice - Lipid Management for Low HDL-Cholesterol
5. Periodontitis and Cardiovascular Events or "PAVE"
Related Studies:
Other Coronary Heart Disease Clinical Trials
Other California Clinical Trials
Other Los Angeles Clinical Trials
Effects of Meditation on Mechanism of Coronary Heart Disease
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