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Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics Clinical Trials Facts presented on Clinical Trials Search is not designed to be a substitute for certified medical advice, travels to or treatment with a real dr.. We aren't doctors. Always consult your mD on Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics Clinical research trials and Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics medical trials occur in many of places across the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectiveness of new does drugs. The role of the studies / undertakings is to figure out certain human healthcare questions. Clinical trials are a popular means for doctors, government agencies, and private sector corporations to locate treatments for all forms of circumstances, including Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics. Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics Clinical Trials and other clinical trials permit volunteers to get medical treatment options before they are available to the masses. Most times the human subjects acquire treatment for free of charge, and sometimes they are paid for their time. Occasionally there is a cost for a Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics clinical trial. Participants oftentimes recieve the finest healthcare available for their Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics condition. Dangers are a reality, nonetheless, and might include extra or frequent physician calls, health hazards (potentially life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.
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Home > "E" Clinical Trials Conditions > Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics  Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics
Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics
For Condition: Respiratory Insufficiency,Anoxemia
Status: Recruiting
Sponsor(s): INO Therapeutics ,
Synopsis: The purpose of this study is to determine the effect of nitric oxide for inhalation on the duration of mechanical ventilation in pediatric patients with AHRF.
Details: Patients will receive 5-ppm study gas (nitric oxide for inhalation or placebo) until Day 28 or extubation, whichever comes first. The following will be performed / recorded at specified times during the study: arterial blood gases, ventilator settings, methemoglobin, PRISM III score, and patient positioning. Selected centers will also be performing plasma cytokine assays, broncho-alveolar lavage fluid assays and a 6 month follow-up assesssment.
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study
Minimum Age/Maximum Age: /16 Years
Genders: Both
Protocol Entry Criteria: Inclusion criteria: - Admitted to pediatric intensive care unit and have the diagnosis of acute repiratory failure - 44 weeks post conceptional age to 16 years of age - Oxygenation Index (OI) >=12 cm H2O/mmHg (as determined by two separate measurement taken 30 minutes to 4 hours apart) - Recent chest x-ray (within 24 hours) showing at least unilateral infiltrations - Mechanically ventilated <= 7 days Exclusion criteria: - Immunocompromised - Received a bone marrow transplant - Active oncological condition - Persistent right to left intracardiac shunt - Cardiovascular surgery within the last 14 days - Status asthmaticus - Decision by primary care physician not to provide full support - Received treatment with nitric oxide for inhalation or other investigational medications within 24 hours prior to study initiation, participating in surfactant trials - Chronically ventilated - Pregnant
Total Enrollment: 350
Location and Contact Information:
The Children's Hospital *Recruiting*
Denver, Colorado, 80218
United States
Recruiting Emily Dobyns
New York Presbyterian Hospital *Not yet recruiting*
New York City, New York, 10021
United States
Not yet recruiting H. Ushay
University of Chicago, Children's Hospital *Recruiting*
Chicago, Illinois, 60637
United States
Recruiting Michael Schrieber
Oregon Health and Science University *Recruiting*
Portland, Oregon, 97239
United States
Recruiting Dana Braner
The Medical University of South Carolina *Not yet recruiting*
Charleston, South Carolina, 29425
United States
Not yet recruiting David Habib
Vanderbilt University Medical Center *Recruiting*
Nashville, Tennessee, 37232
United States
Recruiting Neal Patel
Children's Healthcare of Atlanta at Egleston *Recruiting*
Atlanta, Georgia, 30322
United States
Recruiting James Fortenberry
Chrildren's Hospital of Orange County *Recruiting*
Orange, California, 92868
United States
Recruiting Ronald Bronicki
Additional Information:
Study ID Numbers: INOT-11;
Study Start Date: January 2002
Record last reviewed: April 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00041561
Other Respiratory Insufficiency Studies:
1. Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics
Related Studies:
Other Respiratory Insufficiency Clinical Trials
Other Georgia Clinical Trials
Other Atlanta Clinical Trials
Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics
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