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Effect of Vigabatrin on Brain Blood Flow and Glucose Metabolism



Effect of Vigabatrin on Brain Blood Flow and Glucose Metabolism

For Condition: Epilepsy,Epilepsy, Complex Partial
Status: Completed
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: This study is designed to test the effects of vigabatrin (gamma-vinyl-GABA) an experimental drug used for the treatment of epilepsy. The study will use positron emission tomography (PET scan) to detect areas of the brain receiving increased blood flow and using increased amounts of glucose. Increases in blood flow and glucose use are good indicators of brain activity. Researchers are interested in determining the effects of Vigabatrin on brain blood flow and glucose use.
Details: This double-blind placebo-controlled parallel design protocol will investigate the effects of gamma-vinyl-GABA (vigabatrin--GVG) an experimental antiepileptic drug, on cerebral glucose metabolism (LCMRglc), blood flow (CBF), and seizure frequency, in patients with uncontrolled complex partial (CPS) and secondary generalized seizures (GTCS). Positron Emission Tomography (PET) will be used to measure CBF and LCMRglc.
Eligibility:
Study Type:
  Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Localization-related epilepsy. Uncontrolled seizures. Ability to tolerate tegretol monotherapy. No systemic illness requiring drug therapy. No illness that might be made worse by vigabatrin.
Total Enrollment: 20

Location and Contact Information:

National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda,  Maryland,  20892
United States
 


Additional Information:
Study ID Numbers:
  950008;  95-N-0008
Study Start Date: October 13, 1994
Record last reviewed: August 19, 1999
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001489

Other Epilepsy Studies:
1. Mapping the Areas of the Brain Associated with Language in Children with Epilepsy

2. Genetic Study of Familial Epilepsy

3. Activating Effects of Sleep Deprivation on Synchronized MEG-EEG Recordings of Epilepsy Patients with Non-Diagnostic EEG

4. Functional Coupling of Cortico-Cortical and Cortico-Muscular Connections during Motor Movements: An Electrocorticographic Study of Ipsilateral Motor Control

5. Multicenter trial for adults with partial seizures

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