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Effect of pravastatin on endothelial dysfunction following a single high fat meal Clinical Trials Information presented on Clinical Trials Search isn't designed to be a substitute for certified healthcare advice, travels to or professional assistance using a genuine medical doctor. We are not physicians. Always confer with your dr. about Effect of pravastatin on endothelial dysfunction following a single high fat meal conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Effect of pravastatin on endothelial dysfunction following a single high fat meal Clinical research trials and Effect of pravastatin on endothelial dysfunction following a single high fat meal medical trials happen in hundreds of places across the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually measure the effectualness of new drugs. The intention of the studies / undertakings is to solve certain human healthcare questions. Clinical trials are a popular manner for mDs, government agencies, and private sector companies to locate treatments for all forms of circumstances, such as Effect of pravastatin on endothelial dysfunction following a single high fat meal. Effect of pravastatin on endothelial dysfunction following a single high fat meal Clinical Trials and other clinical trials allow for volunteers to undergo medical treatment choices before they are available to the general public. Some times the human subjects get treatment for free of charge, and sometimes they are paid for their time. Occasionally there is a cost for a Effect of pravastatin on endothelial dysfunction following a single high fat meal clinical trial. Participants frequently get the best healthcare available for their Effect of pravastatin on endothelial dysfunction following a single high fat meal condition. Risks are a reality, nonetheless, and can include extra or frequent physician trips, medical risks (possibly life-jeopardising), and/or the treatment being ineffective. Trials are federally governed with exacting guidelines to protect clinical trials subjects.
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Home > "E" Clinical Trials Conditions > Effect of pravastatin on endothelial dysfunction following a single high fat meal  Effect of pravastatin on endothelial dysfunction following a single high fat meal
Effect of pravastatin on endothelial dysfunction following a single high fat meal
For Condition: Heart Diseases
Status: No longer recruiting
Sponsor(s): National Center for Research Resources (NCRR) ,
Synopsis: There is significant evidence that HMG-CoA reductase inhibitors, a commonly used class of cholesterol lowering medications, reduce the risk of death from coronary disease. Although these medicines lower cholesterol levels, other studies suggest that they have an additional effect on improving blood vessel functioning. It has also been shown that consumption of a fatty meal temporarily alters blood vessel functioning, causing endothelial dysfunction. This study will examine if pravastatin, an HMG-CoA reductase inhibitor, improves blood vessel functioning after a fatty meal. We plan on enrolling 32 subjects, aged 18-40 years, who are healthy with no history of diabetes, smoking, high blood pressure, or heart disease. These subjects will be randomly assigned to initially receive four days of pravastatin or an inactive substance, and then crossed over to the other group. Blood vessel functioning will be monitored by a technique called flow mediated vasoactivity, which uses ultrasound measurement of the forearm artery and its response to temporary occlusion. This primary measure of flow mediated vasoactivity will be done before and after consumption of a fatty meal. We hope to show that treatment with pravastatin prevents the blood vessel dysfunction known to occur after a high fat meal. Secondary outcomes will include measurement of endothelin-l, a mediator of blood vessel functioning, and assessment of changes in lipid profiles. If pravastatin does prevent endothelial dysfunction in this setting, it could lead to further studies about their use in more acute medical settings, including heart attacks or strokes.
Details:
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Placebo Control
Minimum Age/Maximum Age: 18 Years/40 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - No history of the following: hypertension, diabetes mellitus, smoking, and coronary artery disease
Total Enrollment:
Location and Contact Information:
4200 E. 9th Avenue, Box B133
Denver, Colorado, 80262
United States
Additional Information:
Study ID Numbers: NCRR-M01RR00051-1162; M01RR00051
Study Start Date:
Record last reviewed: November 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005117
Other Heart Diseases Studies:
1. High Blood Pressure in the Young
2. Physical Activity Effects on Health Care Utilization
3. Black Pooling Project
4. Nutrition Education
5. Coronary Disease Morbidity and Mortality in a Population
Related Studies:
Other Heart Diseases Clinical Trials
Other Colorado Clinical Trials
Other Denver Clinical Trials
Effect of pravastatin on endothelial dysfunction following a single high fat meal
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