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DPP Outcome Study



DPP Outcome Study

For Condition: Diabetes Mellitus
Status: Completed
Sponsor(s): National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ,
Synopsis: The Diabetes Prevention Program (DPP) was a multi-center trial examining the ability of an intensive lifestyle or metformin to prevent or delay the development of diabetes in a high risk population due to the presence of impaired glucose tolerance (IGT). The DPP has ended early demonstrating that lifestyle reduced diabetes onset by 58% and metformin reduced diabetes onset by 31%. The DPPOS is designed to take advantage of the scientifically and clinically valuable DPP participants. This group of participants is nearly 50% minority and represents the largest IGT population ever studied. Clinically important research questions remain that focus on 1)durability of the prior DPP intervention, 2) determination of the clinical course of precisely known new onset diabetes, in particular regarding CVD, CVD risk factors and atherosclerosis and microvascular disease, 3)close examination of these topics in men vs women and in minority populations.
Details:
Eligibility:
Study Type:
  Interventional, Prevention, Randomized, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study
Minimum Age/Maximum Age: 25 Years/
Genders: Both
Protocol Entry Criteria: Participation as a volunteer in the DPP.
Total Enrollment: 3819

Location and Contact Information:

George Washington University
Rockville,  Maryland, 
United States
 

George Washington University
Rockville,  Maryland, 
United States
 


Additional Information:
Study ID Numbers:
  DK048489; 
Study Start Date: 
Record last reviewed: June 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00038727

Other Diabetes Mellitus Studies:
1. Screening for Patients Needing Kidney, Kidney-Pancreas, or Islet-Cell Transplant

2. Coronary Artery Risk Development in Young Adults (CARDIA)

3. Serum Total Homocysteine and C-Reactive Protein - Ancillary to IDNT

4. Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

5. Strong Heart Study

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