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Doxorubicin and Cyclophosphamide Plus Paclitxael With or Without Trastuzumab in Treating Women With Node-Positive Breast Cancer That Overexpresses HER2 Clinical Trials Facts presented on Clinical Trials Search isn't designed to be a substitute for proven healthcare advice, calls or treatment by using a genuine medical doctor. We aren't mDs. Always confer with your doctor on Doxorubicin and Cyclophosphamide Plus Paclitxael With or Without Trastuzumab in Treating Women With Node-Positive Breast Cancer That Overexpresses HER2 conditions. Clinical Trials Search.org is a website devoted to listing clinical research studies in human subjects. Doxorubicin and Cyclophosphamide Plus Paclitxael With or Without Trastuzumab in Treating Women With Node-Positive Breast Cancer That Overexpresses HER2 Clinical research trials and Doxorubicin and Cyclophosphamide Plus Paclitxael With or Without Trastuzumab in Treating Women With Node-Positive Breast Cancer That Overexpresses HER2 healthcare trials occur in a lot of of places across the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectivity of new does drugs. The role of the studies / undertakings is to solve specific human healthcare questions. Clinical trials are a popular way for doctors, government agencies, and private sector companies to find treatments for all kinds of conditions, including Doxorubicin and Cyclophosphamide Plus Paclitxael With or Without Trastuzumab in Treating Women With Node-Positive Breast Cancer That Overexpresses HER2. Doxorubicin and Cyclophosphamide Plus Paclitxael With or Without Trastuzumab in Treating Women With Node-Positive Breast Cancer That Overexpresses HER2 Clinical Trials and other clinical trials allow for volunteers to access health treatment choices before they are available to the general public. Many times the test subjects get treatment for without cost, and sometimes they are compensated for their time. Occasionally there is a cost for a Doxorubicin and Cyclophosphamide Plus Paclitxael With or Without Trastuzumab in Treating Women With Node-Positive Breast Cancer That Overexpresses HER2 clinical trial. Test subjects typically receive the most effective healthcare possible for their Doxorubicin and Cyclophosphamide Plus Paclitxael With or Without Trastuzumab in Treating Women With Node-Positive Breast Cancer That Overexpresses HER2 condition. Risks are a reality, nonetheless, and could include extra or frequent dr. calls, health hazards (perhaps life-jeopardizing), and/or the treatment being ineffective. Trials are federally regulated with rigid guidelines to protect clinical trials subjects.
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Home > "D" Clinical Trials Conditions > Doxorubicin and Cyclophosphamide Plus Paclitxael With or Without Trastuzumab in Treating Women With Node-Positive Breast Cancer That Overexpresses HER2  Doxorubicin and Cyclophosphamide Plus Paclitxael With or Without Trastuzumab in Treating Women With Node-Positive Breast Cancer That Overexpresses HER2
Doxorubicin and Cyclophosphamide Plus Paclitxael With or Without Trastuzumab in Treating Women With Node-Positive Breast Cancer That Overexpresses HER2
For Condition: stage 3A breast cancer,stage 2 breast cancer
Status: Recruiting
Sponsor(s): National Surgical Adjuvant Breast and Bowel Project (NSABP) , National Cancer Institute (NCI)
Synopsis: RATIONALE: Drugs used in chemotherapy, such as doxorubicin, cyclophosphamide, and paclitaxel, use different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies such as trastuzumab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. It is not yet known whether combination chemotherapy plus trastuzumab is more effective than combination chemotherapy alone for treating breast cancer. PURPOSE: Randomizedphase III trial to compare the effectiveness of combination chemotherapy with or without trastuzumab in treating women who have node-positivestage II or stage IIIA breast cancer that overexpressesHER2.
Details: OBJECTIVES: - Compare the cardiotoxicity of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab (Herceptin) in women with operable, node-positive breast cancer that overexpresses HER2. - Compare the effect of these regimens on disease-free and overall survival of these patients. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to number of positive nodes (1-3 vs 4-9 vs 10 or more), administration of hormonal therapy (tamoxifen vs anastrozole vs neither), surgery/radiotherapy (lumpectomy plus breast irradiation vs lumpectomy plus breast irradiation plus regional irradiation vs mastectomy without radiotherapy vs mastectomy with radiotherapy), paclitaxel schedule (every 3 weeks vs weekly), and participating center. Patients are randomized to one of two treatment arms. - Arm I: Patients receive doxorubicin IV and cyclophosphamide IV over 30 minutes on day 1. Treatment repeats every 21 days for 4 courses. Approximately 3 weeks after the last course, patients receive paclitaxel IV over 3 hours every 21 days for 4 courses OR paclitaxel IV over 1 hour once weekly for 12 weeks (12 doses). - Arm II: Patients receive chemotherapy as in arm I and trastuzumab (Herceptin) IV over 90 minutes on day 1 of the first course of paclitaxel. Trastuzumab is then administered IV over 30 minutes weekly for 51 weeks, beginning on day 8. All patients with estrogen or progesterone receptor-positive tumors receive oral tamoxifen* once daily for 5 years, beginning within 3-12 weeks after the last dose of chemotherapy. Patients who have received prior tamoxifen for prevention may be treated with additional tamoxifen at the discretion of the principal investigator (PI). NOTE: *At the discretion of the PI, oral anastrozole (administered on the same schedule as tamoxifen) may be substituted for tamoxifen for postmenopausal patients. All patients previously treated with lumpectomy undergo breast irradiation beginning after completion of chemotherapy and concurrently with trastuzumab (in arm II) administration. Patients previously treated with mastectomy may also receive radiotherapy. Radiotherapy is administered daily for 5-6 weeks. Patients are followed every 6 months for 5 years and then annually thereafter. PROJECTED ACCRUAL: A total of 2,700 patients will be accrued for this study within 4.75 years.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically or cytologically proven invasive adenocarcinoma of the breast - Stage IIA, IIB, or IIIA - Confined to the breast and ipsilateral axilla (cN0-1) on clinical examination - At least 1 histologically positive axillary node - No lymph nodes clinically fixed to each other or to other structures (cN2) - HER2 strongly positive (3+ by immunostain OR gene amplification by fluorescent in situ hybridization) - Submission of tumor block required - Must have undergone axillary dissection and either total mastectomy OR lumpectomy - Sentinel node dissection allowed, if followed by axillary dissection - No diffuse tumors by mammography in patients treated with lumpectomy - No more than 84 days since prior surgery for breast cancer (e.g., lumpectomy, mastectomy, axillary dissection, or re-excision of lumpectomy margins) - No bilateral malignancy, contralateral mass, or mammographic abnormality unless histologically proven as benign - No suspicious palpable nodes in the contralateral axilla or palpable supraclavicular or infraclavicular nodes unless histologically proven not to be involved with tumor - No primary T4 tumors (for any reason) - No prior breast cancer, including ductal carcinoma in situ - Prior lobular carcinoma in situ allowed - Bone pain allowed provided there is no metastatic disease by x-ray, MRI, or biopsy - Hormone receptor status: - Estrogen and progesterone status known PATIENT CHARACTERISTICS: Age: - Not specified Sex: - Female Menopausal status: - Not specified Performance status: - Not specified Life expectancy: - At least 10 years, excluding diagnosis of breast cancer Hematopoietic: - Platelet count at least 100,000/mm^3* - Absolute neutrophil count at least 1,500/mm^3 (unless determined by the investigator to be normal for ethnic or racial variation) NOTE: *Significant underlying hematologic disorders must be excluded if above upper limit of normal (ULN) Hepatic: - Bilirubin no greater than ULN - SGOT less than 1.5 times ULN - Alkaline phosphatase less than 2.5 times ULN - No systemic hepatic disease that would preclude study participation Renal: - Creatinine normal - No systemic renal disease that would preclude study participation Cardiovascular: - LVEF at least lower limit of normal by MUGA - No cardiovascular disease that would preclude study participation - No angina pectoris requiring treatment - No cardiomegaly on chest x-ray - No prior myocardial infarction by clinical diagnosis or by EKG or other test - No prior congestive heart failure - No prior cardiomyopathy - No cardiac arrhythmia requiring medication - No severe conduction abnormality - No clinically significant valvular disease - No poorly controlled hypertension (diastolic greater than 100 mm Hg), unless adequately controlled by medication - No ventricular hypertrophy on EKG Other: - Not pregnant or nursing - Fertile patients must use effective barrier contraception - No other prior malignancy within the past 5 years except effectively treated carcinoma in situ of the cervix, melanoma in situ, or basal cell or squamous cell skin cancer - No psychiatric or addictive disorders that would preclude informed consent - No sensory or motor neuropathy grade 2 or greater - No contraindications to corticosteroids PRIOR CONCURRENT THERAPY: Biologic therapy: - No prior biologic therapy for this breast cancer Chemotherapy: - No prior chemotherapy for this breast cancer - No prior anthracycline or taxane therapy for any cancer Endocrine therapy: - No prior hormonal therapy for this breast cancer - No concurrent hormonal therapy (e.g., birth control pills or ovarian hormone replacement therapy) - No concurrent raloxifene or other selective estrogen-receptor modulators Radiotherapy: - No prior radiotherapy for this breast cancer - No concurrent radiotherapy to internal mammary nodes - No other concurrent radiotherapy except as specified in study Surgery: - See Disease Characteristics Other: - No other concurrent investigational agents
Total Enrollment:
Location and Contact Information:
Overall Study Official:
EdwardRomond, Study Chair, Markey Cancer Center at University of Kentucky Chandler Medical Center
Medical City Dallas Hospital *Recruiting*
Dallas, Texas, 75230
United States
Recruiting Contact Person 972-566-4737
MBCCOP-Our Lady of Mercy Cancer Center *Recruiting*
Bronx, New York, 10466
United States
Recruiting Contact Person 718-920-9057
Sutter Health Western Division Cancer Research Group *Recruiting*
Greenbrae, California, 94904
United States
Recruiting Contact Person 415-925-7916
CCOP - Oklahoma *Recruiting*
Tulsa, Oklahoma, 74136
United States
Recruiting Contact Person 918-494-7294
Staten Island University Hospital *Recruiting*
Staten Island, New York, 10305
United States
Recruiting Contact Person 718-226-6680
Royal Victoria Hospital - Montreal *Recruiting*
Montreal, Quebec, H3A 1A1
Canada
Recruiting Contact Person 514-843-1572
CCOP - Northern New Jersey *Recruiting*
Hackensack, New Jersey, 07601
United States
Recruiting Contact Person 201-996-5917
John H. Stroger, Jr. Hospital of Cook County *Recruiting*
Chicago, Illinois, 60612-9985
United States
Recruiting Contact Person 312-864-5204
Baylor College of Medicine *Recruiting*
Houston, Texas, 77030
United States
Recruiting Contact Person 713-798-1907
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill *Recruiting*
Chapel Hill, North Carolina, 27599-7295
United States
Recruiting Contact Person 919-843-8087
Kent County Memorial Hospital *Recruiting*
Warwick, Rhode Island, 02886
United States
Recruiting Contact Person 401-737-7010 Ext. 1864
Providence Alaska Medical Center *Recruiting*
Anchorage, Alaska, 99519-6604
United States
Recruiting Kathleen Wilsack-Shue 907-261-3109
CCOP - Iowa Oncology Research Association *Recruiting*
Des Moines, Iowa, 50309-1016
United States
Recruiting Contact Person 515-244-7586
Loma Linda University Cancer Institute at Loma Linda University Medical Center *Recruiting*
Loma Linda, California, 92354
United States
Recruiting Contact Person 909-558-3375 ext. 33377
CCOP - Scott and White Hospital *Recruiting*
Temple, Texas, 76508
United States
Recruiting Contact Person 254-724-1106
CCOP - Mount Sinai Medical Center *Recruiting*
Miami, Florida, 33140
United States
Recruiting Contact Person 305-674-2625
Phoebe Cancer Center at Phoebe Putney Memorial Hospital *Recruiting*
Albany, Georgia, 31701
United States
Recruiting Contact Person 229-312-0354
Creticos Cancer Center at Advocate Illinois Masonic Medical Center *Recruiting*
Chicago, Illinois, 60657
United States
Recruiting Contact Person 773-296-5360
CCOP - Southeast Cancer Control Consortium *Recruiting*
Winston Salem, North Carolina, 27104-4241
United States
Recruiting Contact Person 336-777-3094
Winship Cancer Institute of Emory University *Recruiting*
Atlanta, Georgia, 30322
United States
Recruiting Contact Person 404-778-5377
CCOP - Illinois Oncology Research Association *Recruiting*
Peoria, Illinois, 61602
United States
Recruiting Contact Person 309-636-3605
Cancer Research Center of Hawaii *Recruiting*
Honolulu, Hawaii, 96813
United States
Recruiting Contact Person 808-586-2979
University of Colorado Cancer Center at University of Colorado Health Sciences Center *Recruiting*
Denver, Colorado, 80010
United States
Recruiting Contact Person 720-848-0665
Baptist Regional Cancer Institute - Jacksonville *Recruiting*
Jacksonville, Florida, 32207
United States
Recruiting Contact Person 904-202-7069
North Idaho Cancer Center *Recruiting*
Coeur D Alene, Idaho, 83814
United States
Recruiting Contact Person 208-666-2093
Pacific Shores Medical Group *Recruiting*
Long Beach, California, 90813
United States
Recruiting Contact Person 562-590-0345 ext. 267
South Pointe Hospital *Recruiting*
Cleveland, Ohio, 44122
United States
Recruiting Contact Person 440-473-4293
Medical College of Georgia Comprehensive Cancer Center *Recruiting*
Augusta, Georgia, 30912-4000
United States
Recruiting Contact Person 706-721-6136
University of Arkansas for Medical Sciences *Recruiting*
Little Rock, Arkansas, 72205
United States
Recruiting Contact Person 501-686-8274
Consultants in Blood Disorders and Cancer *Recruiting*
Louisville, Kentucky, 40207
United States
Recruiting Contact Person 502-897-1166 ext. 129
CCOP - Duluth *Recruiting*
Duluth, Minnesota, 55805
United States
Recruiting Contact Person 218-722-8364 Ext. 4739
University of New Mexico Cancer Research and Treatment Center *Recruiting*
Albuquerque, New Mexico, 87131
United States
Recruiting Contact Person 505-272-2776
Akron City Hospital *Recruiting*
Akron, Ohio, 44309
United States
Recruiting Contact Person 330-375-4221
University of Massachusetts Memorial Medical Center - University Campus *Recruiting*
Worcester, Massachusetts, 01655
United States
Recruiting Contact Pesron 508-856-3215
Cancer Research Center at Boston Medical Center *Recruiting*
Boston, Massachusetts, 02118
United States
Recruiting Contact Person 617-638-8434
Berkshire Medical Center *Recruiting*
Pittsfield, Massachusetts, 01201
United States
Recruiting Contact Person 413-496-8205
St. Louis University Hospital Cancer Center *Recruiting*
St. Louis, Missouri, 63110-0250
United States
Recruiting Contact Person 314-577-8855
Providence Cancer Institute at Providence Hospital *Recruiting*
Southfield, Michigan, 48075-9975
United States
Recruiting Contact Person 248-849-5337
CancerCare Manitoba *Recruiting*
Winnipeg, Manitoba, R3E 0V9
Canada
Recruiting Contact Person 204-787-2127
Norton Healthcare Cancer Center *Recruiting*
Louisville, Kentucky, 40202-5070
United States
Recruiting Contact Person 502-629-3465
CCOP - Cancer Research for the Ozarks *Recruiting*
Springfield, Missouri, 65807
United States
Recruiting Contact Person 417-269-4880
CCOP - Virginia Mason Research Center *Recruiting*
Seattle, Washington, 98101
United States
Recruiting Contact Person 206-341-0446
Sutter Cancer Center *Recruiting*
Sacramento, California, 95816
United States
Recruiting Contact Person 916-453-5800
Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha *Recruiting*
Omaha, Nebraska, 68114
United States
Recruiting Contact Person 402-354-5144
Rebecca and John Moores UCSD Cancer Center *Recruiting*
La Jolla, California, 92093-0658
United States
Recruiting Contact Person 858-657-7022
Joe Arrington Cancer Research and Treatment Center *Recruiting*
Lubbock, Texas, 79410-1894
United States
Recruiting Contact Person 806-725-7994
Genesis Regional Cancer Center at Genesis Medical Center *Recruiting*
Davenport, Iowa, 52803
United States
Recruiting Contact Person 563-421-1908
Methodist Cancer Center at Methodist Hospital *Recruiting*
Indianapolis, Indiana, 46206-1367
United States
Recruiting Contact Person 317-962-6597
Wellspan Health - York Cancer Center *Recruiting*
York, Pennsylvania, 17315
United States
Recruiting Contact Person 717-741-8124
National Naval Medical Center *Recruiting*
Bethesda, Maryland, 20889-5000
United States
Recruiting Contact Person 301-496-0905
Montreal General Hospital *Recruiting*
Montreal, Quebec, H3G 1A4
Canada
Recruiting Contact Person 514-934-1934
CCOP - Wichita *Recruiting*
Wichita, Kansas, 67214-3882
United States
Recruiting Contact Person 316-268-5696
Aultman Hospital Cancer Center at Aultman Health Foundation *Recruiting*
Canton, Ohio, 44710
United States
Recruiting Contact Person 330-363-3277
University of Miami Sylvester Cancer Center *Recruiting*
Miami, Florida, 33136
United States
Recruiting Contact Person 305-243-3382
MBCCOP - Gulf Coast *Recruiting*
Mobile, Alabama, 36688
United States
Recruiting Contact Person 251-435-5892
Josephine Ford Cancer Center at Henry Ford Hospital *Recruiting*
Detroit, Michigan, 48202
United States
Recruiting Contact Person 313-916-7277
CCOP - Northern Indiana CR Consortium *Recruiting*
South Bend, Indiana, 46601
United States
Recruiting Contact Person 574-284-7977
CCOP - Christiana Care Health Services *Recruiting*
Wilmington, Delaware, 19899
United States
Recruiting Contact Person 302-733-6227
CCOP - Marshfield Clinic Research Foundation *Recruiting*
Marshfield, Wisconsin, 54449
United States
Recruiting Contact Person 715-389-4177
Camden-Clark Memorial Hospital *Recruiting*
Parkersburg, West Virginia, 26102
United States
Recruiting Contact Person 304-424-2585
CCOP - Central Illinois *Recruiting*
Decatur, Illinois, 62526
United States
Recruiting Contact Person 217-876-6618
Charleston Area Medical Center *Recruiting*
Charleston, West Virginia, 25304-1297
United States
Recruiting Contact Person 304-388-9936
Halifax Medical Center *Recruiting*
Daytona Beach, Florida, 32114
United States
Recruiting Contact Person 904-254-4211
Hartford Hospital *Recruiting*
Hartford, Connecticut, 06102-5037
United States
Recruiting Contact Person 860-545-5363
CCOP - Western Regional, Arizona *Recruiting*
Phoenix, Arizona, 85006-2726
United States
Recruiting Contact Person 602-239-2414
Hillman Cancer Center at University of Pittsburgh Cancer Institute *Recruiting*
Pittsburgh, Pennsylvania, 15213-3489
United States
Recruiting Contact Person 412-647-8205
CCOP - Santa Rosa Memorial Hospital *Recruiting*
Santa Rosa, California, 95403
United States
Recruiting Contact Person 707-521-3834
John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital *Recruiting*
Allentown, Pennsylvania, 18103
United States
Recruiting Contact Person 610-402-0526
Eastern Virginia Medical School *Recruiting*
Norfolk, Virginia, 23507
United States
Recruiting Contact Person 757-668-2406
West Suburban Hospital Medical Center *Recruiting*
Oak Park, Illinois, 60302
United States
Recruiting Contact Person 708-763-2700 ext. 2711
Community Hospital *Recruiting*
Munster, Indiana, 46321
United States
Recruiting Contact Person 219-852-6454
William Beaumont Hospital - Royal Oak *Recruiting*
Royal Oak, Michigan, 48073
United States
Recruiting Contact Person 248-551-6927
Jewish General Hospital - Montreal *Recruiting*
Montreal, Quebec, H3T 1E2
Canada
Recruiting Contact Person 514-340-8222, Ext. 5526
CCOP - Carle Cancer Center *Recruiting*
Urbana, Illinois, 61801
United States
Recruiting Contact Person 217-383-4083
University of Texas Health Science Center at San Antonio *Recruiting*
San Antonio, Texas, 78284-7811
United States
Recruiting Contact Person 210-567-5751
Geisinger Medical Center *Recruiting*
Danville, Pennsylvania, 17822-2001
United States
Recruiting Contact Person 570-271-6362
St. Vincent Hospital *Recruiting*
Green Bay, Wisconsin, 54307-3508
United States
Recruiting Contact Person 920-433-8889
CCOP - Columbia River Oncology Program *Recruiting*
Portland, Oregon, 97213
United States
Recruiting Contact Person 503-216-6262
Dwight David Eisenhower Army Medical Center *Recruiting*
Fort Gordon, Georgia, 30905-5650
United States
Recruiting Contact Person 706-787-2100
Medical College of Wisconsin Cancer Center *Recruiting*
Milwaukee, Wisconsin, 53226
United States
Recruiting Contact Person 414-805-5831
CCOP - Columbus *Recruiting*
Columbus, Ohio, 43206
United States
Recruiting Contact Person 614-488-2118
Green Cancer Center at Scripps Clinic *Recruiting*
La Jolla, California, 92037
United States
Recruiting Contact Person 858-554-9378
CCOP - Merit Care Hospital *Recruiting*
Fargo, North Dakota, 58122
United States
Recruiting Contact Person 701-234-6298
Charles M. Barrett Cancer Center at University Hospital *Recruiting*
Cincinnati, Ohio, 45267-0502
United States
Recruiting Contact Person 513-584-9096
MD Anderson Cancer Center Orlando *Recruiting*
Orlando, Florida, 32806
United States
Recruiting Contact Person 321-841-1859
CCOP - Montana Cancer Consortium *Recruiting*
Billings, Montana, 59101
United States
Recruiting Contact Person 406-259-2245
CCOP - Evanston *Recruiting*
Evanston, Illinois, 60201
United States
Recruiting Contact Person 847-570-2109
Markey Cancer Center at University of Kentucky Chandler Medical Center *Recruiting*
Lexington, Kentucky, 40536-0093
United States
Recruiting Contact Person 859-257-3379
Eastern Maine Medical Center *Recruiting*
Bangor, Maine, 04401
United States
Recruiting Contact Person 207-973-4274
CCOP - Missouri Valley Cancer Consortium *Recruiting*
Omaha, Nebraska, 68131
United States
Recruiting Contact Person 402-991-8070
Arthur G. James Cancer Hospital - Ohio State University *Recruiting*
Columbus, Ohio, 43210-1240
United States
Recruiting Contact Person 614-293-0013
CCOP - Ochsner *Recruiting*
New Orleans, Louisiana, 70121
United States
Recruiting Contact Person 504-842-3708
CCOP - Greenville *Recruiting*
Greenville, South Carolina, 29615
United States
Recruiting Contact Person 864-242-2744
CCOP - Kansas City *Recruiting*
Kansas City, Missouri, 64131
United States
Recruiting Contact Person 816-823-0555
Tulane University Medical Center *Recruiting*
New Orleans, Louisiana, 70112
United States
Recruiting Contact Person 504-585-6450
Cancer Institute of New Jersey *Recruiting*
New Brunswick, New Jersey, 08903
United States
Recruiting Contact Person 732-235-9659
CCOP - Northwest *Recruiting*
Tacoma, Washington, 98405-0986
United States
Recruiting Contact Person 253-403-1461
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C. *Recruiting*
Syracuse, New York, 13217
United States
Recruiting Contact Person 315-472-7504 ext. 281
City of Hope Comprehensive Cancer Center *Recruiting*
Duarte, California, 91010-3000
United States
Recruiting Contact Person 626-359-8111 ext. 64350
St. Mary's Hospital Center *Recruiting*
Montreal, Quebec, H3T 1M5
Canada
Recruiting Contact Person 514-345-3511, Ext. 3378
Puget Sound Oncology Consortium *Recruiting*
Seattle, Washington, 98109
United States
Recruiting Contact Person 206-667-4692
CCOP - Upstate Carolina *Recruiting*
Spartanburg, South Carolina, 29303
United States
Recruiting Contact Person 864-560-6824
Alamance Cancer Center *Recruiting*
Burlington, North Carolina, 27216
United States
Recruiting Contact Person 336-538-7737
CCOP - Dayton *Recruiting*
Kettering, Ohio, 45429
United States
Recruiting Contact Person 937-296-8678
University of Connecticut Cancer Center at University of Connecticut Health Center *Recruiting*
Farmington, Connecticut, 06360-7106
United States
Recruiting Contact Person 860-679-3432
Holden Comprehensive Cancer Center at University of Iowa *Recruiting*
Iowa City, Iowa, 52242-1009
United States
Recruiting Contact Person 319-356-2778
Comprehensive Cancer Center at Wake Forest University *Recruiting*
Winston Salem, North Carolina, 27157-1082
United States
Recruiting Contact Person 336-716-6240
Credit Valley Hospital *Recruiting*
Mississauga, Ontario, L5M 2N1
Canada
Recruiting Contact Person 905-813-4299
CCOP - Kalamazoo *Recruiting*
Kalamazoo, Michigan, 49007-3731
United States
Recruiting Contact Person 269-373-7458
Ottawa Regional Cancer Centre *Recruiting*
Ottawa, Ontario, K1H 1C4
Canada
Recruiting Contact Person 613-737-7700 ext. 6814
Kaiser Permanente Medical Center - Vallejo *Recruiting*
Vallejo, California, 94589
United States
Recruiting Contact Person 707-651-3391
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia *Recruiting*
Philadelphia, Pennsylvania, 19107-5541
United States
Recruiting Contact Person 215-955-1562
Centre Hospitalier de l'Universite de Montreal *Recruiting*
Montreal, Quebec, H2L 4M1
Canada
Recruiting Contact Person 514-890-8000, Ext. 15535
St. Luke's Medical Center *Recruiting*
Milwaukee, Wisconsin, 53215
United States
Recruiting Contact Person 414-389-5507
Oncology Hematology Consultants *Recruiting*
Sarasota, Florida, 34236
United States
Recruiting Contact Person 941-363-5713
CCOP - Atlanta Regional *Recruiting*
Atlanta, Georgia, 30342-1701
United States
Recruiting Contact Person 404-851-7119
CCOP - St. Louis-Cape Girardeau *Recruiting*
St. Louis, Missouri, 63141
United States
Recruiting Contact Person 314-569-6573
Comprehensive Cancer Centers of the Desert *Recruiting*
Palm Springs, California, 92262
United States
Recruiting Contact Person 760-416-4734
Rush Cancer Institute at Rush University Medical Center *Recruiting*
Chicago, Illinois, 60612
United States
Recruiting Contact Person 312-563-2837
MBCCOP - Massey Cancer Center *Recruiting*
Richmond, Virginia, 23298-0037
United States
Recruiting Contact Person 804-628-1893
CCOP - Michigan Cancer Research Consortium *Recruiting*
Ann Arbor, Michigan, 48106
United States
Recruiting Contact Person 734-712-5947
Ellis Fischel Cancer Center at University of Missouri - Columbia *Recruiting*
Columbia, Missouri, 65203
United States
Recruiting Contact Person 573-884-7484
Michigan State University *Recruiting*
East Lansing, Michigan, 48824
United States
Recruiting Contact Person 517-334-2715
Mercy Hospital Cancer Center - Scranton *Recruiting*
Scranton, Pennsylvania, 18501
United States
Recruiting Contact Person 570-342-3675
Vermont Cancer Center at University of Vermont *Recruiting*
Burlington, Vermont, 05405-0075
United States
Recruiting Contact Person 802-656-2278
Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center *Recruiting*
Orange, California, 92868
United States
Recruiting Contact Person 714-456-8549
CCOP - Bay Area Tumor Institute *Recruiting*
Oakland, California, 94609-3305
United States
Recruiting Contact Person 510-465-8502
CCOP - Colorado Cancer Research Program, Incorporated *Recruiting*
Denver, Colorado, 80209-5031
United States
Recruiting Contact Person 303-777-2663 ext. 14
New York Oncology Hematology, P.C. - Albany Regional Cancer Center *Recruiting*
Albany, New York, 12208
United States
Recruiting Contact Person 518-489-2607
Utah Valley Regional Medical Center - Provo *Recruiting*
Provo, Utah, 84604
United States
Recruiting Contact Person 801-408-2246
Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego *Recruiting*
San Diego, California, 92120
United States
Recruiting Contact Person 619-528-5896
CCOP - Southern Nevada Cancer Research Foundation *Recruiting*
Las Vegas, Nevada, 89106
United States
Recruiting Contact Person 702-384-0013
Jewish Hospital of Cincinnati, Incorporated *Recruiting*
Cincinnati, Ohio, 45236
United States
Recruiting Contact Person 513-686-5439 ext. 5434
Albert Einstein Cancer Center *Recruiting*
Philadelphia, Pennsylvania, 19141
United States
Recruiting Contact Person 215-456-3833
CCOP - Grand Rapids *Recruiting*
Grand Rapids, Michigan, 49503
United States
Recruiting Contact Person 616-356-1230
Newark Beth Israel Medical Center *Recruiting*
Newark, New Jersey, 07112
United States
Recruiting Contact Person 973-926-3136
Charles R. Wood Foundation Cancer Center at Glens Falls Hospital *Recruiting*
Glen Falls, New York, 12801
United States
Recruiting Contact Person 518-745-6700
CCOP - Sioux Community Cancer Consortium *Recruiting*
Sioux Falls, South Dakota, 57104
United States
Recruiting Contact Person 605-328-8044
Franklin Square Hospital Center *Recruiting*
Baltimore, Maryland, 21237
United States
Recruiting Contact Person 443-777-7962
CCOP - Metro-Minnesota *Recruiting*
St. Louis Park, Minnesota, 55416
United States
Recruiting Contact Person 952-993-1517
Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina *Recruiting*
Greenville, North Carolina, 27858-4354
United States
Recruiting Contact Person 252-744-9010
Green Mountain Oncology Group *Recruiting*
Bennington, Vermont, 05201
United States
Recruiting Contact Person 802-442-1290
Comprehensive Cancer Institute *Recruiting*
Huntsville, Alabama, 35801
United States
Recruiting Contact Person 256-705-4283
Allegheny General Hospital *Recruiting*
Pittsburgh, Pennsylvania, 15212-4772
United States
Recruiting Contact Person 412-359-6526
Morton Plant Hospital *Recruiting*
Clearwater, Florida, 33756
United States
Recruiting Contact Person 727-461-8690
MBCCOP - San Juan *Recruiting*
San Juan, , 00927-5800
Puerto Rico
Recruiting Contact Person 787-763-1296
Baystate Medical Center *Recruiting*
Springfield, Massachusetts, 01199
United States
Recruiting Contact Person 413-794-3565
Lincoln Medical and Mental Health Center *Recruiting*
Bronx, New York, 10451
United States
Recruiting Contact Person 718-579-4644
Additional Information:
Study ID Numbers: CDR0000067269; NSABP-B-31
Study Start Date:
Record last reviewed: January 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004067
Other Stage 2 Breast Cancer Studies:
1. Tamoxifen With or Without Combination Chemotherapy in Treating Postmenopausal Women With Operable Invasive Breast Cancer
2. Radiation Therapy After Surgery in Treating Women With Early Stage Breast Cancer
3. Doxorubicin and Docetaxel in Treating Women With Stage III Breast Cancer
4. Neoadjuvant and Adjuvant Exemestane in Treating Postmenopausal Women With Locally Advanced Hormone Receptor-Positive Breast Cancer
5. Timing of Menstrual Cycle and Surgery in Treating Premenopausal Women With Stage I, Stage II, or Stage III Breast Cancer
Related Studies:
Other stage 2 breast cancer Clinical Trials
Other New Jersey Clinical Trials
Other Newark Clinical Trials
Doxorubicin and Cyclophosphamide Plus Paclitxael With or Without Trastuzumab in Treating Women With Node-Positive Breast Cancer That Overexpresses HER2
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