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Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea Clinical Trials References presented on Clinical Trials Search isn't meant to be a substitute for proven healthcare advice, trips or professional assistance using a genuine physician. We are not docs. Always confer with your physician about Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea Clinical research trials and Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea healthcare trials happen in hundreds of localities throughout the United States of America. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually evaluate the potency of new drugs. The propose of the studies / projects is to answer particular human health questions. Clinical trials are a popular way for mDs, government agencies, and private sector companies to detect cures for all sorts of conditions, such as Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea. Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea Clinical Trials and other clinical trials allow volunteers to acquire healthcare treatment choices before they are available to the general public. Some times the subjects recieve professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea clinical trial. Subjects frequently obtain the most expert healthcare possible for their Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea condition. Risks are a reality, nevertheless, and can include more or frequent doctor trips, medical risks (possibly life-threatening), and/or the treatment being uneffective. Trials are federally governed with stern guidelines to protect clinical trials patients.
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Home > "D" Clinical Trials Conditions > Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea  Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea
Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea
For Condition: Diarrhea,HIV Infections
Status: Completed
Sponsor(s): VA Medical Center-Gainesville ,
Synopsis: To perform preliminary clinical testing of diethylhomospermine (DEHSPM), a polyamine analogue, for refractory AIDS-related diarrhea. Possibly, DEHSPM will reduce stool volume and frequency in patients with refractory AIDS-related diarrhea.
Details: Possibly, DEHSPM will reduce stool volume and frequency in patients with refractory AIDS-related diarrhea. Patients are initially hydrated for 24 hours, followed by a 3-day baseline period. They then receive intravenous infusions of DEHSPM three times per day for 3 days, followed by observation for 3 days.
Eligibility:
Study Type: Interventional, Treatment, Open Label, Safety Study
Minimum Age/Maximum Age: 18 Years/65 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Patients must have: - ARC or AIDS by CDC criteria. - Uncontrolled diarrhea unresponsive to high-dose, nonspecific antidiarrheal therapy. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: - Known idiopathic ulcerative colitis or Crohn colitis. - Acute stool-culture-positive bacterial colitis. - Acute amoebic colitis. - Pseudomembranous colitis with Clostridium difficile toxin positivity. - Short-gut syndrome. - Chronic pancreatitis. - Ischemic bowel disease. - Enteroenteric fistulae. - Other gastrointestinal tract disorders known to cause diarrhea. - Underlying evidence of immunosuppression other than that related to HIV infection. - Unable or unwilling to have subcutaneous injections. - Clinically significant CNS, hepatic, or renal disease. Concurrent Medication: Excluded: - Other experimental antidiarrheal drugs. - Antibiotic therapy. Prior Medication: Excluded: - Other experimental drugs within 1 month prior to study entry. Required: - At least 2 weeks of prior high-dose, nonspecific antidiarrheal therapy (i.e., loperamide, diphenoxylate hydrochloride-atropine sulfate, or opiates) at maximally tolerable doses.
Total Enrollment:
Location and Contact Information:
Gainesville Veterans Administration Med Ctr
Gainesville, Florida, 32608
United States
Additional Information:
Study ID Numbers: 223A;
Study Start Date:
Record last reviewed: April 1996
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002121
Other Hiv Infections Studies:
1. A Study of MDL 28,574A in HIV-Infected Patients
2. Perceived Changes in Body Build and Image in Patients Who Are Now Taking or Recently Have Stopped Taking Anti-HIV Drugs
3. Simplified Drug Regimens for HIV Patients in ACTG 388 or Patients Who Responded to A First Potent Combination Regimen
4. A Study of Saquinavir and Zalcitabine, Used Alone and Together, in the Treatment of Advanced HIV Infection in Patients Who Stopped Taking or Who Cannot Take Zidovudine
5. Evaluation of an Anti-HIV Drug Combination That Includes a Coated Form of Didanosine (ddI EC) Compared to a Typical Anti-HIV Drug Regimen
Related Studies:
Other HIV Infections Clinical Trials
Other Florida Clinical Trials
Other Gainesville Clinical Trials
Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea
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