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Home > "D" Clinical Trials Conditions > Dichloroacetate Kinetics, Metabolism and Toxicology  Dichloroacetate Kinetics, Metabolism and Toxicology
Dichloroacetate Kinetics, Metabolism and Toxicology
For Condition: Lactic Acidosis
Status: No longer recruiting
Sponsor(s): National Institute of Environmental Health Sciences (NIEHS) ,
Synopsis: Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern. However, DCA is also used as an investigational drug for treating various diseases of adults and children, at doses far greater than those to which humans are normally exposed in the environment. Our research involves how DCA is metabolized by healthy adults and by children with a fatal genetic disease, congenital lactic acidosis (CLA) who are treated with DCA.
Details:
Eligibility:
Study Type: Observational, Screening, Longitudinal, Defined Population, Prospective Study
Minimum Age/Maximum Age: 3 Months/65 Years
Genders: Both
Protocol Entry Criteria: Children with congenital lactic acidosis Healthy adult volunteers
Total Enrollment: 100
Location and Contact Information:
Univ. of Florida
Gainesville, Florida, 32610
United States
Additional Information:
Study ID Numbers: 7355-CP-001;
Study Start Date: December 1994
Record last reviewed: July 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00015015
Other Lactic Acidosis Studies:
1. Dichloroacetate Kinetics, Metabolism and Toxicology
2. Study of the Metabolism of Pyruvate and Related Problems in Patients with Lactic Acidemia
3. Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia
4. Phase III Randomized Study of Sodium Dichloroacetate in Children with Congenital Lactic Acidosis
Related Studies:
Other Lactic Acidosis Clinical Trials
Other Florida Clinical Trials
Other Gainesville Clinical Trials
Dichloroacetate Kinetics, Metabolism and Toxicology
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