|
Diagnostic Study of Gene Alterations in Patients With Acute Myeloid Leukemia Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for certified medical advice, calls or professional assistance using a genuine dr.. We aren't physicians. Always confer with your dr. on Diagnostic Study of Gene Alterations in Patients With Acute Myeloid Leukemia conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Diagnostic Study of Gene Alterations in Patients With Acute Myeloid Leukemia Clinical research trials and Diagnostic Study of Gene Alterations in Patients With Acute Myeloid Leukemia medical trials happen in hundreds of localities throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new does drugs. The intent of the studies / undertakings is to answer particular human health questions. Clinical trials are a popular manner for physicians, government agencies, and private sector corporations to find cures for all kinds of circumstances, like Diagnostic Study of Gene Alterations in Patients With Acute Myeloid Leukemia. Diagnostic Study of Gene Alterations in Patients With Acute Myeloid Leukemia Clinical Trials and other clinical trials permit volunteers to acquire healthcare treatment options before they are available to the general public. Some times the subjects acquire professional assistance for free, and sometimes they are paid for their time. Sometimes there is a cost for a Diagnostic Study of Gene Alterations in Patients With Acute Myeloid Leukemia clinical trial. Participants frequently obtain the most expert healthcare available for their Diagnostic Study of Gene Alterations in Patients With Acute Myeloid Leukemia condition. Dangers are a reality, nevertheless, and can include more or frequent doctor calls, health risks (potentially life-jeopardizing), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.
|
|
|
|
|
|
|
Home > "D" Clinical Trials Conditions > Diagnostic Study of Gene Alterations in Patients With Acute Myeloid Leukemia  Diagnostic Study of Gene Alterations in Patients With Acute Myeloid Leukemia
Diagnostic Study of Gene Alterations in Patients With Acute Myeloid Leukemia
For Condition: Leukemia
Status: Completed
Sponsor(s): National Cancer Institute (NCI) , Cancer and Leukemia Group B
Synopsis: RATIONALE: Diagnostic procedures, such as genetic testing, may improve the ability to detect acute myeloid leukemia and determine the extent of disease. PURPOSE: Diagnostic study to try to detect changes in the genes of patients who have acute myeloid leukemia.
Details: OBJECTIVES: I. Determine the frequency of partial tandem duplication of ALL1 (MLL) in patients with acute myeloid leukemia (AML). II. Determine the predictive value of partial tandem duplication of ALL1 to identify a subset of AML patients who have a short duration of complete remission. PROTOCOL OUTLINE: All samples are obtained from specimens collected on CALGB-9665. No additional blood or bone marrow samples are collected. Samples are examined by Southern blot analysis for gene rearrangement at 11q23. Samples showing evidence of ALL1 gene rearrangement are further analyzed by reverse transcription PCR amplification and/or cytogenetic analysis to detect partial tandem duplication of ALL1. PROJECTED ACCRUAL: Samples from approximately 740 patients will be obtained for this study within 5 years.
Eligibility:
Study Type: Interventional, Diagnostic
Minimum Age/Maximum Age: 15 Years/
Genders:
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- - Prior registration on protocol CALGB-9665 AND Diagnosed with acute myeloid leukemia (AML) AND Treated on a CALGB AML treatment protocol AND Diagnostic bone marrow or blood specimen available --Prior/Concurrent Therapy-- - See Disease Characteristics --Patient Characteristics-- - Age: 15 and over - Performance status: Not specified - Life expectancy: Not specified - Hematopoietic: Not specified - Hepatic: Not specified - Renal: Not specified
Total Enrollment:
Location and Contact Information:
Overall Study Official:
MichaelCaligiuri, Study Chair, Cancer and Leukemia Group B
Veterans Affairs Medical Center - Minneapolis
Minneapolis, Minnesota, 55417
United States
CCOP - North Shore University Hospital
Manhasset, New York, 11030
United States
Dana-Farber Cancer Institute
Boston, Massachusetts, 02115
United States
Barnes-Jewish Hospital
St. Louis, Missouri, 63110
United States
Veterans Affairs Medical Center - Richmond
Richmond, Virginia, 23249
United States
University of Tennessee, Memphis Cancer Center
Memphis, Tennessee, 38103
United States
Comprehensive Cancer Center at Wake Forest University
Winston Salem, North Carolina, 27157-1082
United States
Lineberger Comprehensive Cancer Center, UNC
Chapel Hill, North Carolina, 27599-7295
United States
UCSF Cancer Center and Cancer Research Institute
San Francisco, California, 94143-0128
United States
Schneider Children's Hospital at North Shore
Manhasset, New York, 11030
United States
Duke Comprehensive Cancer Center
Durham, North Carolina, 27710
United States
University of Nebraska Medical Center
Omaha, Nebraska, 68198-3330
United States
University of Chicago Cancer Research Center
Chicago, Illinois, 60637-1470
United States
Holden Comprehensive Cancer Center at The University of Iowa
Iowa City, Iowa, 52242-1009
United States
MBCCOP - Massey Cancer Center
Richmond, Virginia, 23298-0037
United States
New York Presbyterian Hospital - Cornell Campus
New York City, New York, 10021
United States
Veterans Affairs Medical Center - Syracuse
Syracuse, New York, 13210
United States
Memorial Sloan-Kettering Cancer Center
New York City, New York, 10021
United States
Rhode Island Hospital
Providence, Rhode Island, 02903
United States
Veterans Affairs Medical Center - Birmingham
Birmingham, Alabama, 35233-1996
United States
Veterans Affairs Medical Center - Columbia (Truman Memorial)
Columbia, Missouri, 65201
United States
Walter Reed Army Medical Center
Washington D.C., District of Columbia, 20307-5000
United States
Ellis Fischel Cancer Center - Columbia
Columbia, Missouri, 65203
United States
CCOP - Southeast Cancer Control Consortium
Winston Salem, North Carolina, 27104-4241
United States
CCOP - Mount Sinai Medical Center
Miami, Florida, 33140
United States
CCOP - Christiana Care Health Services
Wilmington, Delaware, 19899
United States
Arthur G. James Cancer Hospital - Ohio State University
Columbus, Ohio, 43210-1240
United States
University of California San Diego Cancer Center
La Jolla, California, 92093-0658
United States
University of Minnesota Cancer Center
Minneapolis, Minnesota, 55455
United States
University of Massachusetts Memorial Medical Center
Worcester, Massachusetts, 01655
United States
Vermont Cancer Center
Burlington, Vermont, 05401-3498
United States
Veterans Affairs Medical Center - Togus
Togus, Maine, 04330
United States
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
Syracuse, New York, 13217
United States
Veterans Affairs Medical Center - Memphis
Memphis, Tennessee, 38104
United States
Veterans Affairs Medical Center - Buffalo
Buffalo, New York, 14215
United States
Roswell Park Cancer Institute
Buffalo, New York, 14263-0001
United States
CCOP - Southern Nevada Cancer Research Foundation
Las Vegas, Nevada, 89106
United States
Mount Sinai Medical Center, NY
New York City, New York, 10029
United States
Veterans Affairs Medical Center - Chicago (Westside Hospital)
Chicago, Illinois, 60612
United States
Lombardi Cancer Center
Washington D.C., District of Columbia, 20007
United States
Veterans Affairs Medical Center - Durham
Durham, North Carolina, 27705
United States
State University of New York - Upstate Medical University
Syracuse, New York, 13210
United States
Norris Cotton Cancer Center
Lebanon, New Hampshire, 03756-0002
United States
Marlene & Stewart Greenebaum Cancer Center, University of Maryland
Baltimore, Maryland, 21201
United States
Veterans Affairs Medical Center - San Francisco
San Francisco, California, 94121
United States
Veterans Affairs Medical Center - White River Junction
White River Junction, Vermont, 05009
United States
Additional Information:
Study ID Numbers: CDR0000067123; CLB-9769
Study Start Date: February 1999
Record last reviewed: August 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00003931
Other Leukemia Studies:
1. Darbepoetin alfa Compared With Epoetin alfa in Treating Anemia in Patients Receiving Chemotherapy for Cancer
2. Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation
3. Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer or Nonmalignant Hematologic Disease
4. Monoclonal Antibody Therapy in Treating Patients With Refractory Advanced Solid Tumors or Lymphoma
5. Donor Stem Cell Transplantation in Treating Patients With Relapsed Hematologic Cancer
Related Studies:
Other Leukemia Clinical Trials
Other New York Clinical Trials
Other New York City Clinical Trials
Diagnostic Study of Gene Alterations in Patients With Acute Myeloid Leukemia
|
|
|
|
|
|
|
|
