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Diagnostic Pilot Study of Dual Energy Absorptiometry in the Detection of Osteopenia or Osteoporosis in Patients With Thalassemia Major



Diagnostic Pilot Study of Dual Energy Absorptiometry in the Detection of Osteopenia or Osteoporosis in Patients With Thalassemia Major

For Condition: Thalassemia Major,Osteoporosis,Osteopenia
Status: Completed
Sponsor(s): National Center for Research Resources (NCRR) , Children's Hospital of Philadelphia
Synopsis: OBJECTIVES: I. Determine the frequency and severity of osteopenia and osteoporosis in patients with thalassemia major who undergo dual energy x-ray absorptiometry, and correlate these findings with other relevant endocrinologic measurements.
Details: PROTOCOL OUTLINE: Patients undergo dual energy x-ray absorptiometry for bone density measurements, height (sitting and standing) and weight measurements, comprehensive endocrinologic examination, and assessment of the severity of iron overload at baseline, and then at years 1 and 2.
Eligibility:
Study Type:
  Observational, Screening
Minimum Age/Maximum Age: 6 Years/
Genders: Both
Protocol Entry Criteria: - Diagnosis of thalassemia major with iron overload - Not pregnant - Negative pregnancy test
Total Enrollment: 35

Location and Contact Information:

Overall Study Official:
AlanCohen,  Study Chair,  Children's Hospital of Philadelphia


Additional Information:
Study ID Numbers:
  199/15314;  CHP-GCRC-1655,CHP-IRB-1998-6-1502
Study Start Date: June 1998
Record last reviewed: October 2000
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00006138

Other Osteopenia Studies:
1. Prevention of Steroid-Induced Osteoporosis in Children

2. Diagnostic Pilot Study of Dual Energy Absorptiometry in the Detection of Osteopenia or Osteoporosis in Patients With Thalassemia Major

3. The BONES Project: Building Healthy Bones in Children

4. Zoledronate in Preventing Bone Loss in Premenopausal Women Receiving Chemotherapy After Surgery For Early Stage Breast Cancer

5. Phase III Randomized Study of the Effect of Postmenopausal Estrogen Replacement Therapy on Alveolar Bone Loss

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