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Diabetic Retinopathy and Visual Function Study



Diabetic Retinopathy and Visual Function Study

For Condition: Diabetic Retinopathy,Macular Degeneration,Vision, Subnormal
Status: Completed
Sponsor(s): National Eye Institute (NEI) ,
Synopsis: The purpose of this study is to evaluate possible mechanisms of central visual loss in patients with diabetes mellitus. The visual loss of interest to be investigated is that associated with macular edema (prior to and following laser photocoagulation treatment) and that associated with panretinal photocoagulation. The evaluation will be performed with psychophysical testing, i.e., static perimetry and contrast sensitivity function. Of particular interest, the mechanisms of visual loss associated with macular edema (prior to and following laser photocoagulation) will be further investigated. Photoreceptor-mediated visual loss will be assessed by measurements of the Stiles-Crawford effect. Visual loss mediated by post-receptoral retinal changes will be assessed by measuring the Westheimer spatial desensitization/sensitization effect.
Details: The purpose of this study is to evaluate possible mechanisms of central visual loss in patients with diabetes mellitus. The visual loss of interest to be investigated is that associated with macular edema (prior to and following laser photocoagulation treatment) and that associated with panretinal photocoagulation. The evaluation will be performed with psychophysical testing, i.e., static perimetry and contrast sensitivity function. Of particular interest, the mechanisms of visual loss associated with macular edema (prior to and following laser photocoagulation) will be further investigated. Photoreceptor-mediated visual loss will be assessed by measurements of the Stiles-Crawford effect. Visual loss mediated by post-receptoral retinal changes will be assessed by measuring the Westheimer spatial desensitization/sensitization effect.
Eligibility:
Study Type:  Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Patients with diabetic retinopathy that has not been previously treated are eligible for the study. Patients who have had laser photocoagulation (either focal or scatter) are not eligible.
Total Enrollment: 100

Location and Contact Information:

National Eye Institute (NEI)
Bethesda,  Maryland,  20892
United States
 


Additional Information:
Study ID Numbers:  930037;  93-EI-0037
Study Start Date: November 27, 1992
Record last reviewed: February 23, 2000
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001346

Other Vision, Subnormal Studies:
1. Screening for Studies on Retinovascular Diseases

2. An evaluation of safety and efficacy of Anecortave Acetate vs. placebo in patients with subfoveal choroidal neovascularization(CNV) due to wet age-related macular degeneration(AMD)

3. A Study to Evaluate Retisert in the Treatment of Patients with the "wet" form of Age-Related Macular Degeneration

4. Diabetic Retinopathy and Visual Function Study

5. Identification and Treatment of Feeder Vessels in Macular Degeneration

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