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Home > "D" Clinical Trials Conditions > Development of the Eye Motor System During the First 7 Months of Life in Infants With and Without a Family History of Cross-Eye  Development of the Eye Motor System During the First 7 Months of Life in Infants With and Without a Family History of Cross-Eye
Development of the Eye Motor System During the First 7 Months of Life in Infants With and Without a Family History of Cross-Eye
For Condition: Healthy,Strabismus
Status: Completed
Sponsor(s): National Eye Institute (NEI) ,
Synopsis: Little is known about the development of the ocular, or eye, motor system (the parts of the brain that control how the eyes move) in children. Recent technological and methodological advances now enable researchers to investigate the visual system and ocular motor system of infants, but few findings have been reported. This study hypothesizes that quantitative analysis of "at-risk" infants' eye movement systems can detect abnormalities that precede and predict the onset of strabismus, or cross-eye. We will collect data on the eye movements of a group of infants born between 36 and 44 weeks after conception. These infants will be enrolled between 4 and 24 weeks after birth and followed at 4-week (+/- 5 days) intervals until 28 weeks of age and then once a year until 3 years after birth. The infants will undergo a complete ophthalmic evaluation at each visit after they enroll. At all visits up to 28 weeks of age, they will also undergo analysis of eye movements. We also will monitor the development of ocular alignment and check to detect other visual system abnormalities. The study will provide basic knowledge about the cause of both normal and abnormal alignment of both eyes in infants in the first 28 weeks of life.
Details: Little is known about the development of the ocular motor system in children. We hypothesize that quantitative analysis of "at risk" infants eye movement systems can detect abnormalities that precede and predict the onset of strabismus. We will collect data on the eye movements of a group of infants born between 36 and 44 weeks of post-conceptual age. These infants are enrolled between 4 and 24 weeks after birth and followed at 4 week (+/-5 days) intervals until 28 weeks of age and then yearly until 3 years after birth. After study enrollment infants will undergo a complete ophthalmic evaluation and ocular motor analysis at all study visits. The ocular motor analysis will include evaluation of ocular following, saccadic, pursuit and vergence eye movements using stimulus paradigms that have been specially developed for use in children. Children will be followed on an annual basis after 28 weeks of age until age 3 years to monitor the development of ocular alignment and to detect other visual system abnormalities. Study endpoints for each subject are at 28 weeks of age (ocular motor recordings completed) and 3 years of age (ophthalmic examinations completed). This will provide basic knowledge regarding the etiology of both normal and abnormal binocular alignment in infants in the first 28 weeks of life.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Participants must have a gestational age at birth between 36-42 weeks and birth weight greater than or equal to 2500 gms. Participants must have normal growth and development as assessed by general pediatric examination and growth charts, obtained historically from family and/or pediatrician. Participants must have a normal visual system by ophthalmic examination. Participants must be between the post-conceptual ages of 40 weeks and 70 weeks of age inclusive. Participants must be able to undergo a complete opthalmic evaluation. Participants must be able to undergo standard eye movement recording. Participants must not have any eye diseases. Participants must not have any neurologic disease, developmental delay, congenital genetic syndromes, congenital organ malformations, malformation syndromes or metabolic diseases. Participants must not be on any systemic or ocular medications.
Total Enrollment: 20
Location and Contact Information:
National Eye Institute (NEI)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 000005; 00-EI-0005
Study Start Date: October 22, 1999
Record last reviewed: October 30, 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001143
Other Strabismus Studies:
1. Amblyopia (Lazy Eye) Treatment Study
2. A Trial of Bifocals in Myopic Children With Esophoria
3. Vision In Preschoolers Study (VIP Study)
4. Screening for Studies on Nystagmus and Strabismus
5. Development of the Eye Motor System During the First 7 Months of Life in Infants With and Without a Family History of Cross-Eye
Related Studies:
Other Strabismus Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Development of the Eye Motor System During the First 7 Months of Life in Infants With and Without a Family History of Cross-Eye
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