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Determine the association between the level of SCI with chronic respiratory symptoms, measures of pulmonary function, and respiratory illness. Clinical Trials Information presented on Clinical Trials Search is not designed to be a substitute for proven healthcare advice, travels to or treatment by using a genuine medical doctor. We are not physicians. Always confer with your doctor on Determine the association between the level of SCI with chronic respiratory symptoms, measures of pulmonary function, and respiratory illness. conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Determine the association between the level of SCI with chronic respiratory symptoms, measures of pulmonary function, and respiratory illness. Clinical research trials and Determine the association between the level of SCI with chronic respiratory symptoms, measures of pulmonary function, and respiratory illness. healthcare trials take place in many of cities across the United States of America. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the effectiveness of new drugs. The function of the studies / undertakings is to answer specific human medical questions. Clinical trials are a popular means for mDs, government agencies, and private sector companies to find treatments for all forms of conditions, including Determine the association between the level of SCI with chronic respiratory symptoms, measures of pulmonary function, and respiratory illness.. Determine the association between the level of SCI with chronic respiratory symptoms, measures of pulmonary function, and respiratory illness. Clinical Trials and other clinical trials allow for volunteers to access medical treatment alternatives before they are available to the masses. Many times the test subjects undergo treatment for without cost, and occasionally they are compensated for their time. Occasionally there is a cost for a Determine the association between the level of SCI with chronic respiratory symptoms, measures of pulmonary function, and respiratory illness. clinical trial. Test subjects oftentimes recieve the best healthcare possible for their Determine the association between the level of SCI with chronic respiratory symptoms, measures of pulmonary function, and respiratory illness. condition. Hazards are a reality, nonetheless, and might include additional or frequent doctor trips, healthcare hazards (perhaps life-jeopardizing), and/or the treatment being ineffective. Trials are federally regulated with rigid guidelines to protect clinical trials subjects.
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Home > "D" Clinical Trials Conditions > Determine the association between the level of SCI with chronic respiratory symptoms, measures of pulmonary function, and respiratory illness.  Determine the association between the level of SCI with chronic respiratory symptoms, measures of pulmonary function, and respiratory illness.
Determine the association between the level of SCI with chronic respiratory symptoms, measures of pulmonary function, and respiratory illness.
For Condition: Spinal Cord Injuries
Status: Completed
Sponsor(s): Department of Veterans Affairs , Department of Veterans Affairs Cooperative Studies Program
Synopsis: This study is using a standardized method to assess respiratory function in SCI in order to determine the association between level of SCI with chronic respiratory symptoms, measures of pulmonary function, and respiratory illness, both cross-sectionally and longitudinally.
Details: Primary Objectives: Determine the association between level of spinal cord injury (SCI) with chronic respiratory symptoms, measures of pulmonary function, and respiratory illness, both cross-sectionally and longitudinally. Intervention: None Study Abstract: This study is using a standardized method to assess respiratory function in SCI in order to determine the association between level of SCI with chronic respiratory symptoms, measures of pulmonary function, and respiratory illness, both cross-sectionally and longitudinally. A community-based mail survey was made of 1147 subjects (42% response rate; 2 mailings, n=485). Additional subjects injured >1 year ago underwent testing at the West Roxbury VAMC (FVC, FEV1, TLC and subdivisions, maximal inspiratory and expiratory pressures (MIP/MEP), and completed a health questionnaire based on the ATS DL-78 respiratory questionnaire. Between 10/94-9/98, a cross-sectional cohort of 361 subjects with chronic SCI were tested. Multiple logistic regression was used to examine predictors of respiratory symptoms and chest illness determined from the questionnaire. From the community-based mail survey, SCI with complete cervical injury (CC) the odds reporting ?any wheeze? relative to lower SCI levels (odds ratio (95%CI)) was 3.34 (1.75-6.40), p<0.001, and for ?persistent wheeze? was 2.41 (1.11-5.22), p=0.023. The odds of reporting chronic cough or phlegm were not increased (p=0.40 and 0.07 respectively). Active cigarette smoking was the strongest predictor of respiratory symptoms. In a subset of subjects tested at our VAMC, the odds of CC SCI of reporting chest illness resulting in time off work, indoors at home, or in bed over 3 years before questionnaire completion relative to incomplete injury was 3.00 (1.12-8.01), p=0.029. For 1 PPD current smokers the risk of chest illness was 3.91 (1.71-8.95), p=0.001, for subjects who smoked post injury but quit within the previous 10 years the odds was 3.00 (1.00-8.97), p=0.05. For other former smokers the odds were not significantly increased. Subjects who reported ?persistent wheeze? were nearly 3 times as likely to have reported a chest illness (p=0.036). After using a wheelchair, 31% of CC subjects reported breathlessness, compared to 15% with complete high thoracic, and 11% of lower injuries (p=0.04 trend). Subjects who were not wheelchair athletes, even when lung function and SCI level were noted, were twice as likely not to report breathlessness compared to athletes (p=0.032). Subjects with SCI were able to produce reproducible spirometry. Analysis of the effect of SCI level on lung function is in progress, as are analyses examining predictors of chest illness in the workers tested to date. We have developed a method to assess respiratory function in SCI. Using these methods, complete cervical SCI have been found to experience more wheeze and breathlessness than others with SCI, and are more likely to report a chest illness. However, active cigarette smoking was the most important predictor of chest illness and respiratory symptoms rather than injury level or completeness. Therefore, it is likely that SCI based smoking cessation programs would result in significantly reducing respiratory morbidity in this population. The introduction of exercise programs might also result in a decreased prevalence of breathlessness in complete cervical SCI.
Eligibility:
Study Type: Observational, Screening, Defined Population
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Spinal cord injury of >= 1 year in duration, and no other neuromuscular diseases
Total Enrollment: 400
Location and Contact Information:
Overall Study Official:
CarlosTur, Study Director,
Boston VA Health Care System
West Roxbury, Massachusetts, 02132
United States
Additional Information:
Study ID Numbers: 717B;
Study Start Date: July 1998
Record last reviewed: February 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00011336
Other Spinal Cord Injuries Studies:
1. Determine the association between the level of SCI with chronic respiratory symptoms, measures of pulmonary function, and respiratory illness.
2. Improving Gait in Patients with Spinal Cord Injuries
3. Treatment of Chronic Pain after Spinal Cord Injury (SCI) or Amputation
4. Non-Invasive Electrical Stimulation of the Human Brain
5. Retraining Walking after Spinal Cord Injury
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Determine the association between the level of SCI with chronic respiratory symptoms, measures of pulmonary function, and respiratory illness.
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