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Home > "D" Clinical Trials Conditions > Determination of Kidney Function  Determination of Kidney Function
Determination of Kidney Function
For Condition: Kidney Disease
Status: Recruiting
Sponsor(s): National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ,
Synopsis: Much more about kidney disorders can be learned by determining kidney function. This research proposes to study the kidneys function by several parameters known as glomerular filtration rate (GFR), Renal Plasma Flow (RPF), and Glomerular Capillary Wall Permselectivity. The study will select patients suffering from different types of kidney diseases. These patients will be selected based on the presence of significant amounts of protein in their urine (proteinuria). Standard blood and urine tests are often unable to provide completely accurate information about the kidney. In order for researchers to have a more accurate idea of kidney function, they will use alternative tests. Test materials (para aminohippurate and inulin) will be injected into patients veins that provides information based on their filtration through the kidneys.
Details: The study of various kidney disorders will be facilitated by determinations of true glomerular filtration rate and effective renal plasma flow employing inulin and para aminohippurate (PAH), respectively. Selected patients with proteinuria will be asked to participate in studies of glomerular capillary wall permselectivity calculated from the fractional clearances of the endogenous proteins, albumin and IgG and from the fractional clearances of polydisperse neutral dextran with effective molecular radii ranging from 20-60 angstroms. To achieve this, low molecular weight dextran will be administered by slow IV injection immediately following the inulin and PAH priming doses. Glomerular filtration rate, effective renal plasma flow and glomerular permselectivity will be measured during a standard hydrated clearance study. Timed urine and blood collections will be obtained, typically requiring a total of 60 to 90 minutes. The total test time, including pre-test hydration, is 4 to 5 hours.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Ability to provide informed assent to all aspects of the study after full information is provided. An indication to measure kidney function as accurately as possible in the context of an approved clinical protocol within the intramural programs of the National Institutes of Health: - For minor subjects, a clinical indication will be required. - For adult subjects, a clinical and/or research indication will be required. EXCLUSION CRITERIA: Pregnant females or nursing mothers will be excluded from all aspects of this study (at least until the infant is stable on a regimen of formula feeding). Patients will not receive a test material if there is a history of allergy to that material.
Total Enrollment: 9999
Location and Contact Information:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 890152; 89-DK-0152
Study Start Date: August 24, 1989
Record last reviewed: August 12, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001978
Other Kidney Disease Studies:
1. Living-Related Donor Bone Marrow Immunoregulation in Kidney Transplants
2. Evaluation of New Test Method to Measure Kidney Function
3. Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients
4. Clinical and Basic Investigations into Hermansky-Pudlak Syndrome
5. Determination of Kidney Function
Related Studies:
Other Kidney Disease Clinical Trials
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Determination of Kidney Function
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