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Dacarbazine With or Without Oblimersen (G3139) in Treating Patients With Advanced Malignant Melanoma Clinical Trials References presented on Clinical Trials Search is not intended to be a substitute for proven healthcare advice, trips or professional assistance by using a real medical. We aren't mDs. Always confer with your physician about Dacarbazine With or Without Oblimersen (G3139) in Treating Patients With Advanced Malignant Melanoma conditions. Clinical Trials Search.org is a website devoted to listing clinical research studies in human subjects. Dacarbazine With or Without Oblimersen (G3139) in Treating Patients With Advanced Malignant Melanoma Clinical research trials and Dacarbazine With or Without Oblimersen (G3139) in Treating Patients With Advanced Malignant Melanoma medical trials take place in hundreds of localities across the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually evaluate the effectualness of new does drugs. The purpose of the studies / projects is to solve specific human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to discover treatments for all sorts of conditions, such as Dacarbazine With or Without Oblimersen (G3139) in Treating Patients With Advanced Malignant Melanoma. Dacarbazine With or Without Oblimersen (G3139) in Treating Patients With Advanced Malignant Melanoma Clinical Trials and other clinical trials permit volunteers to access healthcare treatment choices before they are available to the general public. Some times the subjects recieve professional assistance for without cost, and every now and again they are compensated for their time. Sometimes there is a cost for a Dacarbazine With or Without Oblimersen (G3139) in Treating Patients With Advanced Malignant Melanoma clinical trial. Subjects often receive the most expert healthcare possible for their Dacarbazine With or Without Oblimersen (G3139) in Treating Patients With Advanced Malignant Melanoma condition. Risks are a reality, nevertheless, and could include additional or frequent dr. calls, healthcare dangers (perhaps life-jeopardising), and/or the treatment being ineffective. Trials are federally governed with stern guidelines to protect clinical trials subjects.
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Home > "D" Clinical Trials Conditions > Dacarbazine With or Without Oblimersen (G3139) in Treating Patients With Advanced Malignant Melanoma  Dacarbazine With or Without Oblimersen (G3139) in Treating Patients With Advanced Malignant Melanoma
Dacarbazine With or Without Oblimersen (G3139) in Treating Patients With Advanced Malignant Melanoma
For Condition: Recurrent Melanoma,stage 3 melanoma,Stage 4 Melanoma
Status: No longer recruiting
Sponsor(s): Genta ,
Synopsis: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Oblimersen (G3139) may help dacarbazine kill more cancer cells by making tumor cells more sensitive to the drug. It is not yet known if dacarbazine is more effective with or without oblimersen (G3139). PURPOSE: Randomized phase III trial to compare the effectiveness of dacarbazine with or without oblimersen (G3139) in treating patients who have advanced malignant melanoma.
Details: OBJECTIVES: - Compare the survival of patients with advanced malignant melanoma treated with dacarbazine with or without oblimersen (G3139). - Compare the response rate, durable response rate, and progression-free survival of patients treated with these regimens. - Compare the safety of these regimens in this patient population. - Compare the performance status, body weight, and tumor-related symptoms of patients treated with these regimens. OUTLINE: This is a randomized, open-label, multicenter study. Patients are stratified according to ECOG performance status (0 vs 1 or 2), extent of metastases and lactate dehydrogenase (LDH) level (skin subcutaneous and/or lymph node metastases without visceral involvement and normal LDH vs any visceral metastases or elevated LDH), and liver metastases (yes vs no). Patients are randomized to one of two treatment arms. - Arm I: Patients receive dacarbazine IV over 60 minutes on day 1. - Arm II: Patients receive oblimersen (G3139) IV continuously over days 1-6 followed by dacarbazine IV over 60 minutes on day 6. Treatment repeats every 21 days for a maximum of 8 courses in the absence of disease progression or unacceptable toxicity. Patients with stable disease or partial or complete response may be eligible for another 8 courses of treatment in an extension protocol. Patients are followed at least every 2 months for up to 2 years after study. PROJECTED ACCRUAL: A total of 750 patients (375 per arm) will be accrued for this study.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically confirmed malignant melanoma - Progressive disease that is unresectable or metastatic - No primary ocular or mucosal melanoma - At least 1 unidimensionally measurable lesion by physical exam or imaging studies - At least 10 mm by caliper for superficial cutaneous disease - At least 20 mm by contrast-enhanced or spiral CT scan for visceral or nodal/soft tissue disease - No bone metastases as only site of measurable disease - Lesions considered non-measurable include the following: - Bone lesions - Pleural/pericardial effusion - Lymphangitis cutis/pulmonis - Abdominal masses that are not confirmed and followed by imaging - Lesions located in a previously irradiated area - No brain metastases or leptomeningeal disease - Considered a medical candidate for dacarbazine treatment PATIENT CHARACTERISTICS: Age: - Any age Performance status: - ECOG 0-2 Life expectancy: - Not specified Hematopoietic: - Absolute neutrophil count at least 1,500/mm^3 - Platelet count at least 100,000/mm^3 - Hemoglobin at least 8 g/dL (hematopoietic growth factor or transfusion independent) Hepatic: - Bilirubin no greater than 1.5 times upper limit of normal (ULN) - ALT/AST no greater than 2.5 times ULN - Alkaline phosphatase no greater than 2.5 times ULN - Albumin at least 2.5 g/dL - PT/PTT no greater than 1.5 times ULN - No history of chronic hepatitis or cirrhosis Renal: - Creatinine no greater than 1.5 times ULN OR - Creatinine clearance at least 50 mL/min Cardiovascular: - No uncontrolled congestive heart failure - No New York Heart Association class III or IV disease - No symptomatic coronary artery disease (e.g., uncontrolled arrhythmias or recurrent chest pain despite prophylactic medication) - No cardiovascular signs and symptoms at least grade 2 within the past 4 weeks Other: - Intellectually, emotionally, and physically able to maintain an ambulatory infusion pump - Satisfactory venous access - No other significant medical disease - No uncontrolled seizure disorder - No active infection - No uncontrolled diabetes mellitus - No active autoimmune disease - No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix - No known hypersensitivity to phosphorothioate-containing oligonucleotides or dacarbazine - No known HIV infection - Not pregnant or nursing - Negative pregnancy test - Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: - At least 4 weeks since prior immunotherapy, cytokine, biologic, or vaccine therapy in the adjuvant and/or metastatic setting and recovered - No concurrent prophylactic growth factors (e.g., filgrastim [G-CSF], sargramostim [GM-CSF] or epoetin alfa) during course 1 of study Chemotherapy: - No prior cytotoxic chemotherapy, including regional perfusion Endocrine therapy: - No concurrent chronic corticosteroids with an average dose of at least 20 mg of prednisone or equivalent per day Radiotherapy: - See Disease Characteristics - At least 4 weeks since prior radiotherapy and recovered - No prior radiotherapy to measurable target lesions unless progression occurred at that site or measurable disease developed outside the treated area Surgery: - At least 4 weeks since prior surgery and recovered - No prior organ allografts Other: - At least 3 weeks since prior experimental therapy - No prior intratumoral injection therapy to measurable target lesions unless progression occurred at that site or measurable disease developed outside the treated area - No concurrent immunosuppressive drugs - No concurrent anticoagulation therapy except 1 mg/day of warfarin for central line prophylaxis
Total Enrollment:
Location and Contact Information:
Overall Study Official:
StanleyFrankel, Study Chair, Genta
Genta Incorporated
Berkeley Heights, New Jersey, 07922
United States
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, 90095-1781
United States
Additional Information:
Study ID Numbers: CDR0000068616; UCLA-0207109,GENTA-GM301
Study Start Date:
Record last reviewed: April 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00016263
Other Stage 4 Melanoma Studies:
1. Flavopiridol Plus Cisplatin or Carboplatin in Treating Patients With Advanced Solid Tumors
2. Vaccine Therapy With High-Dose Interleukin-2 in Treating Patients With Metastatic Melanoma
3. Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Stage III or Stage IV Melanoma
4. Combination Chemotherapy, Interferon alfa, and Interleukin-2 in Treating Patients With Metastatic Melanoma
5. Inhaled Sargramostim in Treating Patients With Melanoma Metastatic to the Lung
Related Studies:
Other Stage 4 Melanoma Clinical Trials
Other California Clinical Trials
Other Los Angeles Clinical Trials
Dacarbazine With or Without Oblimersen (G3139) in Treating Patients With Advanced Malignant Melanoma
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