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CT Scans in Guiding the Treatment of Patients With Prostate Cancer Who are Undergoing Radiation Therapy



CT Scans in Guiding the Treatment of Patients With Prostate Cancer Who are Undergoing Radiation Therapy

For Condition: stage 4 prostate cancer,stage 1 prostate cancer,stage 2 prostate cancer,stage 3 prostate cancer,recurrent prostate cancer
Status: Recruiting
Sponsor(s): Memorial Sloan-Kettering Cancer Center , National Cancer Institute (NCI)
Synopsis: RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Multiple CT scans may improve the accuracy of radiation therapy for prostate cancer. PURPOSE: Phase I trial to study the effectiveness of multiple CT scans in guiding the treatment of patients who have prostate cancer and are undergoing radiation therapy.
Details: OBJECTIVES: - Compare the accuracy of radiotherapy delivery using multiple CT scans to guide patient positioning vs the standard portal image guided procedure in patients with prostate cancer undergoing external beam radiotherapy. - Determine the reduction in the proportion of patients with large target positioning errors using the CT-guided procedure. - Determine organ motion and setup errors over the course of radiotherapy in order to develop efficient clinical intervention strategies in these patients. OUTLINE: Patients undergo radiotherapy over 9 weeks. Patients undergo a CT scan immediately prior to receiving radiotherapy on treatment days 3-8 and then weekly thereafter. On 3 different days, patients also undergo CT scan immediately after radiotherapy. If the CT scans indicate a correction that exceeds the action level currently in effect, then beginning with the next treatment, the patient's position with respect to the radiation field is adjusted. PROJECTED ACCRUAL: A total of 25 patients will be accrued for this study within 2 years.
Eligibility:
Study Type:
  Interventional, Treatment
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Receiving external beam intensity-modulated radiotherapy for prostate cancer - Able to maintain treatment position for about 40 minutes PATIENT CHARACTERISTICS: Age: - Not specified Performance status: - Not specified Life expectancy: - Not specified Hematopoietic: - Not specified Hepatic: - Not specified Renal: - Not specified PRIOR CONCURRENT THERAPY: Biologic therapy: - Not specified Chemotherapy: - Not specified Endocrine therapy: - Not specified Radiotherapy: - See Disease Characteristics Surgery: - No prior surgery
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
MichaelLovelock,  Study Chair,  Memorial Sloan-Kettering Cancer Center

Memorial Sloan-Kettering Cancer Center *Recruiting*
New York City,  New York,  10021
United States
Recruiting Gikas  Mageras 212-639-7721


Additional Information:
Study ID Numbers:
  CDR0000068728;  NCI-G01-1968,MSKCC-01022
Study Start Date: 
Record last reviewed: June 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00020891

Other Recurrent Prostate Cancer Studies:
1. Chemotherapy Plus Hormone Therapy Versus Androgen Suppression in Treating Patients With Metastatic or Unresectable Prostate Cancer

2. R115777 in Treating Patients With Progressive, Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy

3. Flavopiridol Plus Cisplatin or Carboplatin in Treating Patients With Advanced Solid Tumors

4. Combination Chemotherapy in Treating Patients With Metastatic or Unresectable Solid Tumors

5. Vaccine Therapy in Treating Patients With Progressive Prostate Cancer

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CT Scans in Guiding the Treatment of Patients With Prostate Cancer Who are Undergoing Radiation Therapy

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