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Constraint-based Therapy to Improve Motor Function in Children with Cerebral Palsy Clinical Trials Facts presented on Clinical Trials Search is not designed to be a substitute for certified medical advice, travels to or treatment with a real dr.. We aren't doctors. Always consult your mD on Constraint-based Therapy to Improve Motor Function in Children with Cerebral Palsy conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Constraint-based Therapy to Improve Motor Function in Children with Cerebral Palsy Clinical research trials and Constraint-based Therapy to Improve Motor Function in Children with Cerebral Palsy medical trials occur in many of places across the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectiveness of new does drugs. The role of the studies / undertakings is to figure out certain human healthcare questions. Clinical trials are a popular means for doctors, government agencies, and private sector corporations to locate treatments for all forms of circumstances, including Constraint-based Therapy to Improve Motor Function in Children with Cerebral Palsy. Constraint-based Therapy to Improve Motor Function in Children with Cerebral Palsy Clinical Trials and other clinical trials permit volunteers to get medical treatment options before they are available to the masses. Most times the human subjects acquire treatment for free of charge, and sometimes they are paid for their time. Occasionally there is a cost for a Constraint-based Therapy to Improve Motor Function in Children with Cerebral Palsy clinical trial. Participants oftentimes recieve the finest healthcare available for their Constraint-based Therapy to Improve Motor Function in Children with Cerebral Palsy condition. Dangers are a reality, nonetheless, and might include extra or frequent physician calls, health hazards (potentially life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.
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Home > "C" Clinical Trials Conditions > Constraint-based Therapy to Improve Motor Function in Children with Cerebral Palsy  Constraint-based Therapy to Improve Motor Function in Children with Cerebral Palsy
Constraint-based Therapy to Improve Motor Function in Children with Cerebral Palsy
For Condition: Motor Deficits,Cerebral Palsy
Status: Recruiting
Sponsor(s): National Institute of Child Health and Human Development (NICHD) ,
Synopsis: Pediatric Constraint-Induced (CI) Movement therapy is a rehabilitation program designed to improve motor function in children with partial paralysis. Children with cerebral palsy may have one arm that has significantly greater function (good arm) than the other (bad arm). Restricting the use of the good arm may improve the use of the bad arm. In pediatric CI therapy, the good arm is put in a sling to force increased use of the bad arm. The bad arm is also trained each day for several weeks. This study will test the ability of pediatric CI therapy to improve motor function in children with cerebral palsy.
Details: Cerebral palsy afflicts at least two in 1,000 children in the United States and approximately 2,000,000 children worldwide. Behavioral techniques that impact the plasticity of the nervous system need to be incorporated into practical, evidence-based therapeutic interventions for this condition. CI therapy was derived from basic research with animal and human subjects. Randomized, controlled studies indicate that it can substantially reduce the motor deficit of adult patients with mild to moderately severe chronic strokes and can increase their independence over a period of years. CI therapy involves motor restriction of the less affected upper extremity for a period of 2 to 3 weeks while concurrently training the more affected upper limb. This gives rise to concentrated, repetitive use of the more affected extremity. In adults, CI therapy has lead to a large increase in use-dependent cortical reorganization involving the recruitment of substantial new regions of the brain in the innervation of more affected extremity movement. The study will evaluate CI therapy in a pediatric population. The study will test whether pediatric CI therapy can promote new and improved motor behavior in young children with hemiparesis associated with cerebral palsy. Pediatric CI therapy involves total restraint of the unaffected upper extremity with simultaneous repetitive use of the affected extremity for 6 hours/day for 21 consecutive days. Fifty-two children ages 2 to 6 years old with hemiparetic cerebral palsy will be randomly assigned to either the pediatric CI therapy group or to a control group. The control group will receive standard rehabilitation therapy. All children will have a complete medical evaluation with emphasis on motor function prior to treatment initiation. Children will undergo follow-up testing at 1, 6, and 12 months post-treatment. The primary study assessment tools are the Pediatric Developmental Motor Scales - II (PDMS-II), DASI – II, Bayley Developmental Skills Test, Pediatric Motor Activity Log (PMAL), Child Arm Use Test (CAUT), and Emerging Behavior Scale (EBS).
Eligibility:
Study Type: Interventional, Treatment, Randomized, Single Blind, Active Control, Factorial Assignment, Efficacy Study
Minimum Age/Maximum Age: 2 Years/6 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria - Clinical diagnosis of hemiparetic cerebral palsy consistent with criteria in Swaiman and Russman (1999) and Badawi et al. (1998) - Recommended for participation in pediatric rehabilitation and/or early intervention - Lives within 50 miles of the Civitan Center at University of Alabama at Birmingham or the family is willing to temporarily relocate to the Birmingham area for treatment Exclusion Criteria - Profound bilateral hearing loss with the use of hearing aids - Severe visual impairment - Serious seizure disorder or uncontrolled seizures - Genetic and syndromic conditions historically excluded for CP registries - Familial Spastic Paraplegia - Ataxic Cerebral Palsy - Diagnosis of Pervasive Developmental Disability or autism - Serious or recurring medical complications - Scheduled for surgery within 12 months of study entry
Total Enrollment: 52
Location and Contact Information:
Overall Study Official:
EdwardTaub, Principal Investigator, University of Alabama, Birmingham
University of Alabama at Birmingham *Recruiting*
Birmingham, Alabama, 35294
United States
Recruiting Edward Taub 205-934-2471
Additional Information:
Study ID Numbers: R01HD40692;
Study Start Date: September 2002
Record last reviewed: April 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00061139
Other Motor Deficits Studies:
1. Relaxation Training to Decrease Pain and Improve Function in Adolescents with Cerebral Palsy
2. Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial)
3. Magnesium Sulfate to Prevent Brain Injury in Premature Infants
4. Botulinum Toxin (BOTOX) for Cerebral Palsy
5. Classification of Cerebral Palsy Subtypes
Related Studies:
Other Motor Deficits Clinical Trials
Other Alabama Clinical Trials
Other Birmingham Clinical Trials
Constraint-based Therapy to Improve Motor Function in Children with Cerebral Palsy
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