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Home > "C" Clinical Trials Conditions > Computed Tomographic Colonography in Detecting Colorectal Polyps or Cancer Computed Tomographic Colonography in Detecting Colorectal Polyps or Cancer
Computed Tomographic Colonography in Detecting Colorectal Polyps or Cancer
For Condition: Rectal Cancer,Colon Cancer
Status: Recruiting
Sponsor(s): Robert H. Lurie Cancer Center , National Cancer Institute (NCI)
Synopsis: RATIONALE: Computed tomographic colonography may be a less invasive diagnostic procedure than colonoscopy for detecting colorectalpolyps or colorectal cancer. PURPOSE: Diagnostic trial to study the effectiveness of computed tomographic colonography in detecting colorectal polyps or cancer.
Details: OBJECTIVES: - Determine the optimal computed tomographic colonography (CTC) regimen for the detection of colorectal polyps or cancer. - Determine the sensitivity, specificity, and positive and negative predictive values of CTC. - Compare the strengths and weaknesses of CTC vs colonoscopy. OUTLINE: Patients undergo computed tomographic colonography (CTC) followed by standard colonoscopy. CTC and colonoscopy are performed on the same day, whenever possible or within 1 week. Patients who do not tolerate colonoscopy undergo barium enema study. A comparison is made between the findings from CTC and colonoscopy (or barium enema study, if necessary). PROJECTED ACCRUAL: Approximately 235 patients will be accrued for this study.
Eligibility:
Study Type: Interventional, Diagnostic
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Patients who are undergoing work up for suspected colorectal polyp or neoplasm and who are scheduled to undergo colonoscopy for any of the following indications: - Occult bleeding - Iron deficiency anemia - Persistent change in bowel habits - Polyps found during sigmoidoscopy - Strong family history - Prior adenomatous polyps - No toxic colitis, acute colitis, diverticulitis, peritonitis, bowel obstruction, or inflammatory bowel disease - No active rectal bleeding with or without hemodynamic instability - Patients must have undergone standard barium enema or colonoscopy bowel preparation prior to study - Colon must be thoroughly cleaned or have minimal amount of stool PATIENT CHARACTERISTICS: Age: - Over 18 Performance status: - Not specified Life expectancy: - Not specified Hematopoietic: - Not specified Hepatic: - Not specified Renal: - Not specified Cardiovascular: - No recent myocardial infarction Pulmonary: - No recent pulmonary embolus Other: - No inability to tolerate sedation - No adverse reaction to anxiolytics PRIOR CONCURRENT THERAPY: Biologic therapy - Not specified Chemotherapy - Not specified Endocrine therapy - Not specified Radiotherapy - Not specified Surgery - Not specified Other - See Disease Characteristics
Total Enrollment:
Location and Contact Information:
Overall Study Official:
FrankMiller, Study Chair, Robert H. Lurie Cancer Center
Robert H. Lurie Comprehensive Cancer Center at Northwestern University *Recruiting*
Chicago, Illinois, 60611
United States
Recruiting Colin Howden 312-695-4018
Additional Information:
Study ID Numbers: CDR0000067727; NU-9915,NCI-G00-1736
Study Start Date:
Record last reviewed: June 2000
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005789
Other Colon Cancer Studies:
1. Computerized Tomographic Colonography Compared With Standard Diagnostic Procedures in Detecting Colorectal Neoplasia
2. Interleukin-12 in Treating Patients With Cancer in the Abdomen
3. Genetic Markers in Patients With Colorectal Cancer
4. Oxaliplatin Plus Irinotecan in Treating Patients With Metastatic Gastrointestinal Cancer
5. Capecitabine and Irinotecan in Treating Patients With Locally Advanced, Recurrent, or Metastatic Colorectal Cancer
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Computed Tomographic Colonography in Detecting Colorectal Polyps or Cancer
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