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Complementary Naturopathic Medicine for Periodontitis Clinical Trials Facts presented on Clinical Trials Search is not designed to be a substitute for certified medical advice, travels to or treatment with a real dr.. We aren't doctors. Always consult your mD on Complementary Naturopathic Medicine for Periodontitis conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Complementary Naturopathic Medicine for Periodontitis Clinical research trials and Complementary Naturopathic Medicine for Periodontitis medical trials occur in many of places across the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectiveness of new does drugs. The role of the studies / undertakings is to figure out certain human healthcare questions. Clinical trials are a popular means for doctors, government agencies, and private sector corporations to locate treatments for all forms of circumstances, including Complementary Naturopathic Medicine for Periodontitis. Complementary Naturopathic Medicine for Periodontitis Clinical Trials and other clinical trials permit volunteers to get medical treatment options before they are available to the masses. Most times the human subjects acquire treatment for free of charge, and sometimes they are paid for their time. Occasionally there is a cost for a Complementary Naturopathic Medicine for Periodontitis clinical trial. Participants oftentimes recieve the finest healthcare available for their Complementary Naturopathic Medicine for Periodontitis condition. Dangers are a reality, nonetheless, and might include extra or frequent physician calls, health hazards (potentially life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.
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Home > "C" Clinical Trials Conditions > Complementary Naturopathic Medicine for Periodontitis  Complementary Naturopathic Medicine for Periodontitis
Complementary Naturopathic Medicine for Periodontitis
For Condition: Periodontitis
Status: Completed
Sponsor(s): National Center for Complementary and Alternative Medicine (NCCAM) ,
Synopsis: This study aims to assess selected naturopathic medicines for adult periodontitis and to identify variables that influence successful outcomes when traditional and alternative approaches to preventing and treating periodontal diseases are combined. Collaboration between Kaiser Permanente, Oregon Health Science University and the National College of Naturopathic Medicine provides an unsurpassed environment for such investigations. Periodontitis is a major cause of tooth loss and negatively impacts systemic health. The limitations of traditional periodontal treatment have compelled scientists and clinicians to investigate new remedies, and naturopathic medicine holds several promising interventions. Because they are used to improve elements of host resistance that are known to be important in periodontal health and disease, three naturopathic medicines are potential adjuncts in preventing and treating periodontitis. Connective tissue components are enzymatically degraded in periodontitis. In naturopathy, Connective Tissue Nutrient Formula (CTNF) (vitamins A, C and D, glucosamine sulfate, oligoproanthocyanindins, copper, zinc, manganese, boron, silicon, magnesium, and calcium) is prescribed specifically to enhance the integrity of key connective tissue elements and improve their resistance to degradation. Periodontitis begins when permeability of the oral sulcular epithelium permits pathogenic bacterial components to invade deeper periodontal connective tissues. In naturopathy, glutamine is prescribed to reduce oral-intestinal epithelial membrane permeability. Chronic activation of the hypothalamic-pituitary-adrenal (HPA) axis during the stress response, is a risk factor for periodontitis. Adaptogenic herbs (AH) (Panax ginseng, Withania somnifera and Eleutherococcus senticosus) are prescribed by naturopathic physicians to reverse the impact of bacterial and psychosocial stressors. Because glutamine, CTNF and AH target pathophysiologic mechanisms known to underline periodontitis, they are compelling candidates in clinical and mechanistic investigations of complementary medicine approaches to the management of periodontitis. Kaiser Permanente adult periodontitis patients will serve as subjects and receive standard periodontal treatment. Three of the four randomly assigned groups will also receive supplements of glutamine, CTNF, or AH. We will determine the effects of these supplements on clinical outcomes (attachment loss, pocket depths, indicators of inflammation, plaque composition, need for periodontal surgery, acute periodontal problems, tooth loss). In addition to completing the battery of self-report measures (stress, coping, quality of life), study subjects will provide samples of blood, saliva, gingival cervicular fluid and bacterial dental plaque. These samples will be examined as part of the Laboratory Core to identify biologic and genetic characteristics that correlate with successful outcomes. Storage of portions of the samples will allow future examination of additional variables as part of the Developmental Projects carried out as the Craniofacial Complementary & Alternative Center is established and Phase III trials are undertaken.
Details:
Eligibility:
Study Type: Interventional, Treatment, Randomized
Minimum Age/Maximum Age: 25 Years/80 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Adult periodontitis
Total Enrollment:
Location and Contact Information:
Overall Study Official:
AlexWhite, Principal Investigator, Center for Health Research, Kaiser Foundation Hospitals
The Oregon Health Sciences University (OHSU)
Portland, Oregon,
United States
Additional Information:
Study ID Numbers: 1 P50 AT00076-01P3; 1 P50 AT00076-01
Study Start Date:
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00010634
Other Periodontitis Studies:
1. Complementary Naturopathic Medicine for Periodontitis
2. Effects of Low-Dose Doxycycline on Oral Bone Loss
Related Studies:
Other Periodontitis Clinical Trials
Other Oregon Clinical Trials
Other Portland Clinical Trials
Complementary Naturopathic Medicine for Periodontitis
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