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Comparison of Quality of Life in Patients Undergoing More Intensive versus Less Intensive Chemotherapy and Radiation Preceding a Bone Marrow Transplant



Comparison of Quality of Life in Patients Undergoing More Intensive versus Less Intensive Chemotherapy and Radiation Preceding a Bone Marrow Transplant

For Condition: Bone Marrow Transplantation
Status: No longer recruiting
Sponsor(s): Warren G Magnuson Clinical Center (CC) ,
Synopsis: This study will examine the quality of life of patients undergoing bone marrow transplantation to treat a blood disease. It will look at how this therapy affects many areas of life, including for example, personal relationships, work, and general emotional state. The information gained may lead to improved ways of dealing with problems that may arise before or during treatment. Patients receiving bone marrow stem cells donated by a family member may participate in this study. They will be interviewed before treatment begins and will complete questionnaires at the following intervals: 1. day of admission to the hospital 2. day of the transplant 3. 30 days after the transplant 4. 100 days after the transplant 5. 1 year after therapy 6. 2 years after therapy All questionnaires to be completed after discharge from the hospital will be scheduled during a regular follow-up visit. Each questionnaire takes about 15 to 20 minutes to complete. The information provided is confidential and will not be shared.
Details: Clinical research in blood stem cell and bone marrow transplantation documents improvements in disease free intervals, disease free survival, and the severity of treatment related toxicities. However, it is important for patients and families to know the quality of life (QOL) they can expect following an allogeneic transplant. In this longitudinal study we will compare the QOL of patients undergoing a non-myeloablative allogeneic peripheral blood stem cell transplant (A-PBSCT) prospectively with that of a myeloablative A-PBSCT. Subjects (n=106) over the age of 18 will be enrolled. Measures of quality of life (Medical Outcomes Study Short Form-MOS SF-36 and Functional Assessment of Cancer Therapy-General and Bone Marrow Transplant - FACT-G and FACT-G/BMT) and symptom distress (Symptom Distress Scale - SDS) will be administered prior to transplant (baseline) and at set interval post transplant. Data will be analyzed using repeated measures analysis of variance and regression analysis.
Eligibility:
Study Type:
  Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Male or female subjects 18 years of age or older. Able to read English or Spanish. Hematological disease requiring A-PBSCT. Signed informed consent for QOL study.
Total Enrollment: 106

Location and Contact Information:

Warren G. Magnuson Clinical Center (CC)
Bethesda,  Maryland,  20892
United States
 


Additional Information:
Study ID Numbers:
  000002;  00-CC-0002
Study Start Date: October 6, 1999
Record last reviewed: September 22, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004994

Other Bone Marrow Transplantation Studies:
1. Giving Epstein-Barr Virus (EBV) Specific Killer T Lymphocytes to Patients who have had Donor Marrow Grafts.

2. Relationship Between Personality and Coping Styles in Bone Marrow Transplant Candidates

3. Retention of Bone Marrow Donors in a National Registry

4. Reducing the Risk of Transplant Rejection: Simultaneous Kidney and Bone Marrow Transplant

5. Blood and Marrow Transplant Clinical Research Network

Related Studies:

Other Bone Marrow Transplantation Clinical Trials
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Comparison of Quality of Life in Patients Undergoing More Intensive versus Less Intensive Chemotherapy and Radiation Preceding a Bone Marrow Transplant

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