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Home > "C" Clinical Trials Conditions > Comparing Gabapentin and Lorazepam for Treating Alcohol Withdrawal  Comparing Gabapentin and Lorazepam for Treating Alcohol Withdrawal
Comparing Gabapentin and Lorazepam for Treating Alcohol Withdrawal
For Condition: Alcoholism
Status: Recruiting
Sponsor(s): National Institute on Alcohol Abuse and Alcoholism (NIAAA) ,
Synopsis: This study will evaluate a safe and useful medication for outpatient detoxification that is as effective as benzodiazepines in the short-term, and more effective in the protracted withdrawal period. Gabapentin (Neurontin) will be compared to a standard benzodiazepine, lorazepam (Ativan), for its effectiveness in treating alcohol withdrawal.
Details:
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Placebo Control, Safety/Efficacy Study
Minimum Age/Maximum Age: 18 Years/70 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Meets criteria for alcohol dependence and uncomplicated alcohol withdrawal syndrome. - Subjects must be medically stable (not likely to require hospitalization for medical complications within 10 days). - Have a clinical withdrawal assessment prior to study. - Must be medically acceptable for study treatment. Considerations include no past or present physical disorder that is likely to deteriorate during participation. No ECG abnormality which would likely worsen during participation and no clinical laboratory abnormality that would also suggest deterioration during treatment. - Able to read, write, and speak English. - Have a negative urine drug screen for benzodiazepines or other sedative hypnotics, opiates, and stimulates prior to entering the study. Exclusion Criteria: - Current diagnosis of any other substance dependence syndrome other than alcohol dependence (excluding nicotine and caffeine dependence). - Use of pharmacological agents within the last 14 days that are known to lower the seizure threshold or augment or decrease the alcohol withdrawal syndrome. - History of alcohol withdrawal seizures, epilepsy or delirium tremens. - Diagnosis of schizophrenia, bipolar disorder or dementia. - Liver function tests higher than normal. - History of hepatic encephalopathy, jaundice, ascites, diabetes, or renal disease. - Females who are pregnant or nursing. - Subjects with known sensitivity of previous adverse reaction to gabapentin, lorazepam, or other benzodiazepines. - History of severe GI disease which might render absorption of the medication difficult or produce medical instability of the patient during detoxification which would include active peptic ulcer disease, ulcerative colitis, regional colitis, or evidence by history or physical exam of GI bleeding. - Unable to provide an informed consent.
Total Enrollment: 160
Location and Contact Information:
Medical University of South Carolina *Recruiting*
Charleston, South Carolina, 29425
United States
Recruiting Dr. Malcolm 843-792-5214
Additional Information:
Study ID Numbers: NIAAAMAL1076106;
Study Start Date:
Record last reviewed: July 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00011297
Other Alcoholism Studies:
1. Combination Nicotine Replacement for Alcoholic Smokers
2. Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex Traits
3. Sertraline and Cognitive Therapy in Depressed Alcoholics
4. Smoking Cessation in Alcoholism Treatment
5. Drug Treatment for Alcoholics with Post-Traumatic Stress Disorder
Related Studies:
Other Alcoholism Clinical Trials
Other South Carolina Clinical Trials
Other Charleston Clinical Trials
Comparing Gabapentin and Lorazepam for Treating Alcohol Withdrawal
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