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Home > "C" Clinical Trials Conditions > Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma

Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma



Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma

For Condition: adult T-cell leukemia and lymphoma,angioimmunoblastic T-cell lymphoma,childhood small noncleaved cell lymphoma,anaplastic large cell lymphoma,Non-Hodgkin's Lymphoma
Status: Recruiting
Sponsor(s): German High-Grade Non-Hodgkin's Lymphoma Study Group ,
Synopsis: RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies such as rituximab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. It is not yet known whether combination chemotherapy is more effective with or without rituximab in treating aggressivenon-Hodgkin's lymphoma. PURPOSE: Randomizedphase III trial to compare the effectiveness of cyclophosphamide, doxorubicin, vincristine, and prednisone with or without rituximab in treating older patients who have aggressive non-Hodgkin's lymphoma.
Details: OBJECTIVES: - Compare the efficacy of cyclophosphamide, doxorubicin, vincristine, and prednisone with or without rituximab in elderly patients with aggressive non-Hodgkin's lymphoma. - Compare the rate of complete remission, rate of primary progression, tumor control, disease-free survival, overall survival, and relapse after radiotherapy in patients treated with these regimens. - Compare the safety and side effects of these regimens in these patients. OUTLINE: This is a randomized, open-label, multicenter study. Patients are stratified according to participating center, value for serum lactic dehydrogenase (no greater than upper limit of normal [ULN] vs greater than ULN), bulky disease present (no vs yes), stage (I or II vs III or IV), general ECOG status of patient (0 or 1 vs 2), and age (61 to 70 vs 71-80). Patients are randomized to 1 of 4 treatment arms. Patients with CD20-negative lymphoma are randomized to arms I or II only. - Prephase treatment:Patients receive vincristine IV on day -6 and prednisone on day -6 to day 0 before initiating CHOP chemotherapy. - Arm I: Patients receive standard CHOP chemotherapy comprising cyclophosphamide IV, doxorubicin IV, and vincristine IV on day 1 and oral prednisone on days 1-5. Patients also receive filgrastim (G-CSF) subcutaneously once daily on days 6-12 of each CHOP course. Treatment repeats every 2 weeks for 6 courses. - Arm II: Patients receive standard CHOP chemotherapy and G-CSF as in arm I for a total of 8 courses. - Arm III: Patients receive standard CHOP chemotherapy and G-CSF as in arm I. Patients also receive rituximab IV before CHOP every 2 weeks for a total of 8 courses. - Arm IV: Patients receive standard CHOP chemotherapy and G-CSF as in arm II. Patients also receive rituximab IV before CHOP every 2 weeks for a total of 8 courses. In all arms, treatment continues in the absence of disease progression or unacceptable toxicity. Beginning 3-6 weeks after completion of the last chemotherapy course, after complete recovery of bone marrow, and after complete remision of mucositis, patients with sites of initial bulky disease or extranodal involvement undergo radiotherapy 5 times a week for 4 weeks. Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter. PROJECTED ACCRUAL: Approximately 880 patients (220 per treatment arm) will be accrued for this study within 5 years.
Eligibility:
Study Type:
  Interventional, Treatment
Minimum Age/Maximum Age: 61 Years/80 Years
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically confirmed aggressive non-Hodgkin's lymphoma (NHL) by an excisional biopsy of a lymph node or an extensive biopsy of an extranodal involvement (if there is no lymph node involvement) - CD20^+ B-cell lymphoma or CD20^- B-cell and T-cell lymphoma allowed - B-cell NHL including the following: - Stage III follicular lymphoma - Stage III follicular lymphoma and diffuse B-cell lymphoma - Lymphoblastic precursor B-cell lymphoma - Diffuse large cell B-cell lymphoma - Centroblastic - Immunoblastic - Plasmablastic - Anaplastic large cell - T-cell-rich B-cell lymphoma - Primary effusion lymphoma - Intravasal B-cell lymphoma - Primary mediastinal B-cell lymphoma - Mantle zone lymphoma, blastoid - Burkitt's lymphoma - Burkitt-like lymphoma - Aggressive marginal zone lymphoma (monocytoid) - T-cell NHL including the following: - Lymphoblastic precursor T-cell lymphoma - Peripheral T-cell lymphoma (PTCL) not otherwise specified (NOS) - Lennert's lymphoma - T-zone lymphoma - T-cell lymphoma of the angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) type - Anaplastic large cell lymphoma - ALK^+ - ALK^- - Extranodal NK/T-cell lymphoma, nasal type - Intestinal T/NK-cell lymphoma (with or without enteropathy) - Hepatosplenic gamma-delta lymphoma - Subcutaneous panniculitis-like PTCL - Aggressive T/NK PTCL - Anaplastic large-cell NHL, NOS - Bone marrow involvement no more than 25% - No lymphoma that is clearly restricted to the CNS or originating from the gastrointestinal tract PATIENT CHARACTERISTICS: Age - 61 to 80 Performance status - ECOG 0-2 OR - Karnofsky 60-100% Life expectancy - Not specified Hematopoietic - WBC at least 2,500/mm^3 - Platelet count at least 100,000/mm^3 Hepatic - Bilirubin no greater than 2 times upper limit of normal (ULN) - No active hepatitis infection Renal - Creatinine no greater than 2 times ULN Cardiovascular - No Canadian Cardiovascular Society class III or IV angina pectoris - No New York Heart Association class III or IV cardiac failure - Ejection fraction at least 50% - Fractional shortenings at least 25% by echocardiography or nuclear medicine examination Pulmonary - FEV1 at least 50% - Diffusion capacity at least 50% Other - No uncontrolled diabetes mellitus - No known hypersensitivity to any study medications - No other concurrent malignancy - HIV negative PRIOR CONCURRENT THERAPY: Biologic therapy - Not specified Chemotherapy - No prior chemotherapy Endocrine therapy - Not specified Radiotherapy - No prior radiotherapy Surgery - Not specified Other - Must not have already initiated lymphoma therapy (except for the prephase treatment specified for this study) - No other concurrent lymphoma therapy - No concurrent participation in another treatment study
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
MichaelPfreundschuh,  Study Chair,  Universitatsklinik - Saarland

Klinikum Darmstadt *Recruiting*
Darmstadt,  ,  64283
Germany
Recruiting Contact  Person 49-6151-1070

Klinikum der Friedrich-Schiller Universitaet Jena *Recruiting*
Jena,  ,  07747
Germany
Recruiting Contact  Person 49-3641-939100

Leonardis Clinic *Recruiting*
Kornwestheim,  ,  70806
Germany
Recruiting Contact  Person 49-221-8907

General Hospital *Recruiting*
CELLE,  ,  29223
Germany
Recruiting Contact  Person 49-723124

Regional Hospital Am Plattenwald *Recruiting*
Bad Friedrichshall,  ,  74172
Germany
Recruiting Contact  Person 49-71-36280

Lukaskrankenhaus Neuss *Recruiting*
Neus,  ,  41464
Germany
Recruiting Contact  Person 49 2131 888 2710

Caritasklinik St. Theresia *Recruiting*
Saarbrucken,  ,  66113
Germany
Recruiting Contact  Person 49 681 406461

Knappschaft Krankenhaus *Recruiting*
Bochum,  ,  44892
Germany
Recruiting Contact  Person 49-234-2990

Saint Agnes Hospital *Recruiting*
Bocholt,  ,  46397
Germany
Recruiting Contact  Person 49-2871-200

Stadisches Krankenhaus Martha Maria Halle-Dolau *Recruiting*
Halle,  ,  06120
Germany
Recruiting Contat  Person 49-3455590

Regional Hospital Neumarkt *Recruiting*
Neumarkt,  ,  92318
Germany
Recruiting Contact  Person 49 9181 4200

Ernst-Moritz-Arndt University *Recruiting*
Greifswald,  ,  17489
Germany
Recruiting Contact  Person 49-383477951

Klinikum Nuernberg - Klinikum Nord *Recruiting*
Nuremberg,  ,  90340
Germany
Recruiting Contact  Person 49 11 398 2460

Krankenhaus Nordwest *Recruiting*
Frankfurt,  ,  60488
Germany
Recruiting Contact  Person 49-69-7601

Klinikum Krollwitz *Recruiting*
Halle,  ,  06120
Germany
Recruiting Contact  Person 49-3455570

University Wurzburg *Recruiting*
Wurzburg,  ,  97070
Germany
Recruiting Contact  Person 49 931 201 7007

Universitaetsklinikum Ulm *Recruiting*
Ulm,  ,  89081
Germany
Recruiting Contact  Person 49 731 5024391

Krankenhaus Bietigheim *Recruiting*
Bietigheim,  ,  74321
Germany
Recruiting Contact  Person 49-7142-790

Ev. Hospital Oldenburg *Recruiting*
Oldenburg,  ,  26122
Germany
Recruiting Contact  Person 49 441 236242

Oncological Specialist Practice *Recruiting*
Harrislee,  ,  24955
Germany
Recruiting Wolfgang  Grimm 49-461-700-030

Staedt Klinikum Karlsruhe GGMBH *Recruiting*
Karlsruhe,  ,  76133
Germany
Recruiting Contact  Person 49-721-9740

Medizinische Klinik Am Lukas - Krankenhaus *Recruiting*
Bunde,  ,  32257
Germany
Recruiting Contact  Person 49-52231670

Humaine - Clinic *Recruiting*
Bad Saarow,  ,  15523
Germany
Recruiting Contact  Person 49-336-3170

Evang. Hospital *Recruiting*
Holzminden,  ,  37603
Germany
Recruiting Contact  Person 49-5531-7050

Klinikum Grosshadern der Ludwig-Maximilians Universitaet Muenchen *Recruiting*
Munich,  ,  81377
Germany
Recruiting Contact  Person 49-89-70952202

Franz Hospital Dulmen *Recruiting*
Dulmen,  ,  48249
Germany
Recruiting Contact  Person 49-2594-9200

Specialist Practice for Oncology *Recruiting*
Aschaffenburg,  ,  63739
Germany
Recruiting Martine  Klausmann 49-6021-34270

Regional Hospital Mayen *Recruiting*
Mayen,  ,  56727
Germany
Recruiting Contact  Person 49 2651 830

Klinikum St. Marien *Recruiting*
Amberg,  ,  92224
Germany
Recruiting Contact  Person 49-9621-380

Kreiskrankenhaus Radebeul *Recruiting*
Radebeul,  ,  01445
Germany
Recruiting Contact  Person 49 351 8330

University Hospital Zurich *Recruiting*
Zurich,  ,  8091
Switzerland
Recruiting Contact  Person 41 1255 1111

St. Marien Hospital Ludwighafen *Recruiting*
Ludwigshafen,  ,  67067
Germany
Recruiting Contact  Person 49 621 55012254

Hospital Bad Cannstatt *Recruiting*
Stuttgart,  ,  70374
Germany
Recruiting Contact  Person 49 711 52050

Deaconess Kaiserswerth, FNK *Recruiting*
Dusseldorf,  ,  40489
Germany
Recruiting Contact  Person 49-211-4090

Hospital Neunkirchen gGmbH *Recruiting*
Neunkirchen,  ,  66538
Germany
Recruiting Contact  Person 49 6821 180

Robert-Bosch-Krankenhaus *Recruiting*
Stuttgart,  ,  70376
Germany
Recruiting Contact  Person 49 711 81010

Frankenwald Klinik *Recruiting*
Kronach,  ,  96317
Germany
Recruiting Contact  Person 49 9261 590

Municipal Hospital Complex *Recruiting*
Pforzheim,  ,  75175
Germany
Recruiting Contact  Person 49 7231 9690

Ev. Hospital Unna *Recruiting*
Unna,  ,  59403
Germany
Recruiting Contact  Person 49 2303 106 385

Hans - Susemihl - Krankenhaus *Recruiting*
Emden,  ,  26721
Germany
Recruiting Contact  Person 49-4921-980

Leopoldina - Krankenhaus *Recruiting*
Schweinfurt,  ,  97422
Germany
Recruiting Contact  Person 49 971 7203111

Universitaetsklinik Goettingen *Recruiting*
Gottingen,  ,  37075
Germany
Recruiting Contact  Person 49-551390

Regional Hospital Munchberg *Recruiting*
Munchberg,  ,  95213
Germany
Recruiting Contact  Person 49-9281-57-411

Universitaetsklinikum Essen *Recruiting*
ESSEN,  ,  45147
Germany
Recruiting Contact  Person 49-201-72311

Medizinische Kl. Klinikum Innenstadt Universitaet Muenchen *Recruiting*
Munich,  ,  80336
Germany
Recruiting Contact  Person 49 89 5160 2205

Johannes Gutenberg University *Recruiting*
Mainz,  ,  55131
Germany
Recruiting Contact  Person 49 6131 1771

St. Marien Hospital - Muelheim an der Ruhr *Recruiting*
Mulheim/Ruhr,  ,  45468
Germany
Recruiting Contact  Person 49 208 3050

Katharinenhospital *Recruiting*
Stuttgart,  ,  70174
Germany
Recruiting Contact  Person 49 711 278 5601

Medizinische Universitaetsklinik I *Recruiting*
Cologne,  ,  50924
Germany
Recruiting Contact  Person 49 221 4784400

Municipal Hospital Complex *Recruiting*
Villingen-Schwenningen,  ,  78045
Germany
Recruiting Contact  Person 49 7721 930

Ev. Hospital Bethesda *Recruiting*
Monchengladbach,  ,  41061
Germany
Recruiting Contact  Person 49 2161 9810

Klinikum Minden *Recruiting*
Minden,  ,  32423
Germany
Recruiting Contact  Person 49 571 801 4501

Krankenhaus D Barmherzigen Brueder *Recruiting*
Regensburg,  ,  93049
Germany
Recruiting Contact  Person 49 941 3692151

Dreifaltigkeits Hospital *Recruiting*
Lippstadt,  ,  59555
Germany
Recruiting Contact  Person 49 2741 7580

Praxis fuer Haematologie und Onkologie *Recruiting*
Koblenz,  ,  D-56068
Germany
Recruiting Hubert  Koeppler 49-261-304-930

Saint Johannes Hospital Dortmund *Recruiting*
Dortmund,  ,  44137
Germany
Recruiting Contact  Person 49-231-18430

Hematologische Onkologische Praxis *Recruiting*
Regensburg,  ,  93047
Germany
Recruiting Robert  Dengler 49 941 466342

Staedtische Krankenhaus Kiel *Recruiting*
Kiel,  ,  23116
Germany
Recruiting Contact  Person 49-431-1697

Klinikum Krefeld GmbH *Recruiting*
Krefeld,  ,  47805
Germany
Recruiting Contact  Person 49 2151 322 850

Evangelische Krankenhaus Hamm *Recruiting*
Hamm,  ,  59063
Germany
Recruiting Contact  Person 49-2381-5891333

Gemeinschaftspraxis Fuer Innere Medizin, Haematologie Und Internistische Onkologie *Recruiting*
Ansbach,  ,  91522
Germany
Recruiting Sebastian  Mueller 49-981-970-790

Hospital Complex Bernburg *Recruiting*
Bernburg,  ,  06406
Germany
Recruiting Contact  Person 49-3471-340

Deaconess Hospital *Recruiting*
Schwabisch Hall,  ,  74523
Germany
Recruiting Contact  Person 49 791 7531

Barmherzigen Bruder Hospital *Recruiting*
Trier,  ,  54292
Germany
Recruiting Contact  Person 49 651 2080

Haematologisch Onkologische Praxis *Recruiting*
Aachen,  ,  52070
Germany
Recruiting  Tummes 49-241-500-051

Klinikum Ernst Von Bergmann *Recruiting*
Potsdam,  ,  14467
Germany
Recruiting Contact  Person 49 331 241 6002

Municipal Hospital Complex of the University *Recruiting*
Kaiserslautern,  ,  67655
Germany
Recruiting Contact  Person 49-6312030

Hospital Tutzing *Recruiting*
Tutzing,  ,  82327
Germany
Recruiting Contact  Person 49 8158 230

Medizinische Universitaetsklinik und Poliklinik *Recruiting*
Heidelberg,  ,  69115
Germany
Recruiting Contact  Person 49-6221-568011

Ev. Hospital Witten-Herdecke *Recruiting*
Witten,  ,  58455
Germany
Recruiting Contact  Person 49 42302 1750

Municipal Hospital Munich Schwarbing *Recruiting*
Munich,  ,  80804
Germany
Recruiting Contact  Person 49 89 30680

Evang. Jung-Stilling Hospital *Recruiting*
Siegen,  ,  57074
Germany
Recruiting Contact  Person 49 271 3333

Allgemeines Krankenhaus Hagen *Recruiting*
Hagen,  ,  58095
Germany
Recruiting Contact  Person 49-23312010

St. Elisabeth Hospital *Recruiting*
Saarlouis,  ,  66713
Germany
Recruiting Contact  Person 49 6831 160

Medizinische Hochschule Hannover *Recruiting*
Hannover,  ,  30625
Germany
Recruiting Contact  Person 49-511-53240

Hospital Complex of the University Regensburg *Recruiting*
Regensburg,  ,  93042
Germany
Recruiting Contact  Person 49 941 20800

St. Lukas - Clinic Solingen *Recruiting*
Solingen,  ,  42697
Germany
Recruiting Contact  Person 49 212 7051

Universitaets-Krankenhaus Eppendorf *Recruiting*
Hamburg,  ,  20251
Germany
Recruiting Contact  Person 49-40-428030

Haematologisch-Onkologische Praxis Altona *Recruiting*
Hamburg,  ,  D-22765
Germany
Recruiting Ulrich  Kleeberg 49-40-380212

Marienhospital *Recruiting*
Vechta,  ,  49377
Germany
Recruiting Contact  Person 49 444 1990

Hematologische Praxis *Recruiting*
Oldenburg,  ,  26121
Germany
Recruiting Hans  Fokke-Hinrichs 49 441 973 6229

Evang. Deaconess Hospital Freiburg *Recruiting*
Freiburg,  ,  79110
Germany
Recruiting Contact  Person 49-7612700

Hospital Maria-Hilf II *Recruiting*
Monchengladbach,  ,  41063
Germany
Recruiting Contact  Person 49 2161 892208

II. Medizinische Klinik *Recruiting*
Aschaffenburg,  ,  63739
Germany
Recruiting Contact  Person 49-6021-320

Lung Clinic Cologne-Merheim *Recruiting*
Cologne-Merheim,  ,  51109
Germany
Recruiting Contact  Person 49 221 8907

Evang. Stift St. Martin gGmbH Koblenz *Recruiting*
Koblenz,  ,  56068
Germany
Recruiting Contact  Person 49 261 3170

Krankenhaus Hohe Warte Mediziniche Klinik *Recruiting*
Bayreuth,  ,  95445
Germany
Recruiting Contact  Person 49-921-2800

Hospital Complex North, Heidberg *Recruiting*
Hamburg,  ,  22413
Germany
Recruiting Contact  Person 49-40-52713449

Muenchen Onkol. Praxis Elisenhof *Recruiting*
Munich,  ,  80335
Germany
Recruiting Contact  Person 49-89-55079820

Mutterhaus der Borromaerinnen *Recruiting*
Trier,  ,  54290
Germany
Recruiting Contact  Person 49 651 947 2377

Dr. Horst-Schmidt-Kliniken *Recruiting*
Wiesbaden,  ,  65199
Germany
Recruiting Contact  Person 49 611 433009

Municipal Hospital Complex Zwickau *Recruiting*
Zwickau,  ,  08060
Germany
Recruiting Contact  Person 49 375 510

Klinikum Ludwigsburg *Recruiting*
Ludwigsburg,  ,  71640
Germany
Recruiting Contact  Person 49 7141 9990

St. Antonius Hospital *Recruiting*
Eschweiler,  ,  52249
Germany
Recruiting Contact  Person 49-2403-761280

Red Cross Hospital Kassel *Recruiting*
Kassel,  ,  34121
Germany
Recruiting Contact  Person 49-561-30860

Deutsche Klinik fuer Diagnostik *Recruiting*
Wiesbaden,  ,  65191
Germany
Recruiting Contact  Person 49 611 577648

Neurologische Klinik der Henriettenstiftung *Recruiting*
Hannover,  ,  30559
Germany
Recruiting Contact  Person 49-511-2893423

Municipal Hospital Complex *Recruiting*
Fulda,  ,  36043
Germany
Recruiting Contact  Person 49-661840

Klinikum Frankfurt *Recruiting*
Frankfurt/Oder,  ,  15236
Germany
Recruiting Contact  Person 49-3355480

Medizinische Poliklinik *Recruiting*
Bonn,  ,  53111
Germany
Recruiting Contact  Person 49-228-2870

Medical University Hospital Homburg *Recruiting*
Homburg,  ,  66421
Germany
Recruiting Contact  Person 49-6841-160

Jakobi Krankenhaus *Recruiting*
Rheine,  ,  48431
Germany
Recruiting Contact  Person 49 5971 460

Medizinischen Klinik Dr. R. Schindlbeck *Recruiting*
Herrsching,  ,  82211
Germany
Recruiting Hermann  Dietzfelbinger 49-8152 29280

Municipal Hospital Munich *Recruiting*
Munich,  ,  81737
Germany
Recruiting Contact  Person 49 89 67942651

Kreiskrankenhaus *Recruiting*
Herford,  ,  32049
Germany
Recruiting Contact  Person 49-5221940

Haematologische Praxis *Recruiting*
Augsburg,  ,  86150
Germany
Recruiting Hans  Slawik 49-821-513143

City Hospital Triemli *Recruiting*
Zurich,  ,  8063
Switzerland
Recruiting Contact  Person 41 14662202

Klinikum Oldenburg *Recruiting*
Oldenburg,  ,  26133
Germany
Recruiting Contact  Person 49 441 403 2614

Medizinische Klinik I *Recruiting*
Dresden,  ,  01307
Germany
Recruiting Contact  Person 49-351-4500

Robert Roessle Klinik *Recruiting*
Berlin,  ,  13125
Germany
Recruiting Contact  Person 49-9417-1492

Thoraxklinik Heidelberg *Recruiting*
Heidelberg,  ,  69126
Germany
Recruiting Contact  Person 49-62213961

Hospital Complex Rostock Suedstadt *Recruiting*
Rostock,  ,  18059
Germany
Recruiting Contact  Person 49-381-44-010

Stadt Krankenhaus Gutersloh *Recruiting*
Gutersloh,  ,  33332
Germany
Recruiting Contact  Person 49-5241-8324657

Regional Hospital Waldbrol *Recruiting*
Waldbrol,  ,  51545
Germany
Recruiting Contact  Person 49 2291 821313

Klinikum Erfurt *Recruiting*
Erfurt,  ,  99089
Germany
Recruiting Contact  Person 49-361-7810

Schwerpunktpraxis Fuer Haematologie Und Onkologie *Recruiting*
Saarbruecke,  ,  N-66113
Germany
Recruiting Joerg  Schimke 49 681 47 3575

Regional Hospital Bad Hersfeld *Recruiting*
Bad Hersfeld,  ,  36251
Germany
Recruiting Contact  Person 49-6621-880

AllG. Krankenhaus Altona *Recruiting*
Hamburg,  ,  22763
Germany
Recruiting Contact  Person 49-40-88220

Centre for Internal Medicine Gieben *Recruiting*
Gieben,  ,  35392
Germany
Recruiting Contact  Person 49-641994

Krankenhaus Siloah - Medizinische Klinik II *Recruiting*
Hannover,  ,  30449
Germany
Recruiting Contat  Person 49-511-9270

Saint Josef Hospital *Recruiting*
Bochum,  ,  44791
Germany
Recruiting Contact  Person 49-234-509421

Ev. Hospital *Recruiting*
Mulheim/Ruhr,  ,  45466
Germany
Recruiting Contact  Person 49 208 3091

St. Elisabeth Hospital Ravensburg *Recruiting*
Ravensburg,  ,  88212
Germany
Recruiting Contact  Person 49 751 870

University of Marburg *Recruiting*
Marburg,  ,  35043
Germany
Recruiting Contact  Person 49-6421-286239

Regional Hospital Aurich *Recruiting*
Aurich,  ,  26603
Germany
Recruiting Contact  Person 49-4941-941802

Municipal Complex of Ludwigshafen *Recruiting*
Ludwigshafen,  ,  67063
Germany
Recruiting Contact  Person 49 621 5030

St. Vincenz Hospital Limburg *Recruiting*
Limburg,  ,  65549
Germany
Recruiting Contact  Person 49 6431 2920

Ev. Diakome Krankenhaus gGmBH *Recruiting*
Bremen,  ,  28239
Germany
Recruiting Contact  Person 49-421-6102

Hospital Kuchwald Chemnitz *Recruiting*
Chemnitz,  ,  09113
Germany
Recruiting Contact  Person 49-371-333-42700

Haematologisch-Onkologische Scwerpunktpraxis *Recruiting*
Berlin,  ,  13357
Germany
Recruiting Ilona  Blau 49-30-461-4857

Martin - Luther Hospital *Recruiting*
Schleswig,  ,  24837
Germany
Recruiting Contact  Person 49 4621 8120

Carl - Thiem - Klinkum Cottbus *Recruiting*
Cottbus,  ,  03048
Germany
Recruiting Contact  Person 49-355-460

Hospital St. Georg *Recruiting*
Leipzig,  ,  04129
Germany
Recruiting Contact  Person 49 341 9090

Hospital Complex Hoyerswerda *Recruiting*
Hoyerswerda,  ,  02977
Germany
Recruiting Contact  Person 49-3571-440

University Rostock *Recruiting*
Rostock,  ,  18057
Germany
Recruiting Contact  Person 49 381 4947408

Gemeinschaftspraxis Innere Medizin *Recruiting*
Jena,  ,  D-07743
Germany
Recruiting Sabine  Hahnfeld 49-3641-56246

Medical Academy Magdeburg *Recruiting*
Magdeburg,  ,  39120
Germany
Recruiting Contact  Person 49 391 672500

Hospital Wetzler *Recruiting*
Wetzlar,  ,  35578
Germany
Recruiting Contact  Person 49 644 1791

Regional Hospital Heidenheim *Recruiting*
Heidenheim,  ,  89522
Germany
Recruiting Contact  Person 49-7321330

Klinikum Lippe - Lemgo *Recruiting*
Lemgo,  ,  32657
Germany
Recruiting Contact  Person 49 5261 264122

Regional Hospital Traunstein *Recruiting*
Traunstein,  ,  83278
Germany
Recruiting Contact  Person 49 861 988760

Rheinische Friedrich-Wilhelms-Universitat *Recruiting*
Bonn,  ,  D-53113
Germany
Recruiting Contact  Person 49-228-287-5159

Medical University of Lubeck *Recruiting*
Lubeck,  ,  23538
Germany
Recruiting Contact  Person 49 451 5006641

III Medizinische Klinik Mannheim *Recruiting*
Mannheim,  ,  D-68305
Germany
Recruiting Contact  Person 49 21 3833359

Paracelsus - Clinic Osnabruck *Recruiting*
Osnabruck,  ,  49076
Germany
Recruiting Contact  Person 49 541 9660

Marienhospital / Ruhr University Bochum *Recruiting*
Herne,  ,  44625
Germany
Recruiting Contact  Person 49-2323-4991319

St. Bonifatius Hospital Lingen *Recruiting*
Lingen,  ,  49808
Germany
Recruiting Contact  Person 49-5-91-9100

Zentralklinikum Augsburg *Recruiting*
Augsburg,  ,  86156
Germany
Recruiting Contact  Person 49-821-40001

St. Elisabeth Hospital Thuine *Recruiting*
Thuine,  ,  49832
Germany
Recruiting Contact  Person 49 5902 9510

Klinikum Offenburg *Recruiting*
Offenburg,  ,  77654
Germany
Recruiting Contact  Person 49 49 781 4720

Evangelisches Krankenhaus Essen Werden *Recruiting*
Essen-Werden,  ,  45239
Germany
Recruiting Contact  Person 49-201-40890

Saint Elisabeth / Saint Barbara Hospital *Recruiting*
Halle/Saale,  ,  06110
Germany
Recruiting Contact  Person 49-34521330

Praxis Fuer Haematologie Internistische Onkologie *Recruiting*
Koeln,  ,  D-50677
Germany
Recruiting Stephan  Schmitz 49 221 932 1620

Robert - Koch Hospital *Recruiting*
Gehrden,  ,  30989
Germany
Recruiting Contact  Person 49-5108690

Diakonissen-Krankenhaus Stuttgart *Recruiting*
Stuttgart,  ,  70176
Germany
Recruiting Contact  Person 49 711 9910

Oncological Specialist Practice *Recruiting*
Hildesheim,  ,  31134
Germany
Recruiting Contact  Person 49-51-21-51-36-55

Buergerhospital Stuttgart *Recruiting*
Stuttgart,  ,  70191
Germany
Recruiting Contact  Person 49 711 253 2000

Kliniken St. Antonius *Recruiting*
Wuppertal,  ,  42283
Germany
Recruiting Contact  Person 49 202 2992595

Hospital Altstadt Magdeburg *Recruiting*
Magdeburg,  ,  39104
Germany
Recruiting Contact  Person 49 391 7910

St. Marien Hospital at Katholisches Krankenhaus hagen gem. GmbH *Recruiting*
Hagen,  ,  58095
Germany
Recruiting Contact  Person 49-2331

Caritas - Krakenhaus Lebach *Recruiting*
Lebach,  ,  66822
Germany
Recruiting Contact  Person 49 6881 501266

Medizinische Klinik und Poliklinik der Universitaet Muenster *Recruiting*
Munster,  ,  48129
Germany
Recruiting Contact  Person 49 251 5347617

St. Johannes Hospital - Medical Klinik II *Recruiting*
Duisburg,  ,  47166
Germany
Recruiting Contact  Person 49-203-5462480

University Leipzig Clinic of Internal Medicine *Recruiting*
Leipzig,  ,  04103
Germany
Recruiting Contact  Person 49 341 972


Additional Information:
Study ID Numbers:
  CDR0000269015;  EU-20243,DSHNHL-1999-1A
Study Start Date: 
Record last reviewed: December 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00052936

Other Adult T-Cell Leukemia And Lymphoma Studies:
1. Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Aggressive Non-Hodgkin's Lymphoma

2. Tipifarnib in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma

3. Gemcitabine, Carboplatin, and Dexamethasone With or Without Rituximab in Treating Patients With Relapsed or Primary Refractory Lymphoma

4. Cyclophosphamide, Doxorubicin, Vincristine, Prednisone, and Radiation Therapy Followed By Rituximab and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Stage I or Stage II Non-Hodgkin's Lymphoma

5. Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma

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Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma

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