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Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome Clinical Trials Data presented on Clinical Trials Search is not meant to be a substitute for qualified health advice, visits or treatment with a real mD. We are not doctors. Always consult your doctor about Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome Clinical research trials and Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome healthcare trials happen in many of places across the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectivity of new drugs. The purpose of the studies / projects is to solve particular human medical questions. Clinical trials are a popular way for doctors, government agencies, and private sector companies to discover cures for all varieties of conditions, such as Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome. Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome Clinical Trials and other clinical trials allow volunteers to have health treatment alternatives before they are available to the masses. Some times the human subjects obtain treatment for without cost, and sometimes they are compensated for their time. Occasionally there is a cost for a Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome clinical trial. Test subjects oftentimes receive the most effective healthcare possible for their Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome condition. Dangers are a reality, however, and may include extra or frequent physician visits, healthcare dangers (possibly life-jeopardising), and/or the treatment being uneffective. Trials are federally governed with rigorous guidelines to protect clinical trials patients.
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Home > "C" Clinical Trials Conditions > Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome  Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome
Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome
For Condition: Refractory Anemia,Myeloid Leukemia
Status: No longer recruiting
Sponsor(s): Children's Oncology Group , National Cancer Institute (NCI)
Synopsis: RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with bone marrow transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. It is not yet known which treatment regimen is more effective for acute myelogenous leukemia or myelodysplastic syndrome. PURPOSE: Randomized phase III trial to compare the effectiveness of different chemotherapy regimens with or without bone marrow transplantation in treating children who have acute myelogenous leukemia or myelodysplastic syndrome.
Details: OBJECTIVES: - Increase the remission induction rate to greater than 85% in children with untreated acute myelogenous leukemia (AML) or myelodysplastic syndromes (MDS) by replacing daunorubicin (DNR) with idarubicin (IDA) in intensively timed DCTER chemotherapy (dexamethasone, cytarabine (ARA-C), thioguanine, etoposide, and daunorubicin) in the first 4 days of each course. - Increase the remission rate further by comparing the efficacy of consolidation chemotherapy with intensively timed IDA DCTER/DCTER vs fludarabine (FAMP), ARA-C, and IDA in maintaining remission and in achieving remission in patients with M2 disease (5%-29% blasts in marrow) at the end of induction chemotherapy. - Compare overall survival, event-free survival, and disease-free survival in patients who receive consolidation with IDA DCTER/DCTER vs FAMP, ARA-C, and IDA. - Compare overall survival, event-free survival, and disease-free survival in patients receiving intensification with the Capizzi II regimen (high-dose ARA-C and asparaginase) vs those receiving a matched-related allogeneic bone marrow transplantation. - Compare overall survival, event-free survival, and disease-free survival in patients treated with interleukin-2 (IL-2) vs standard follow up care after Capizzi II intensification. - Determine whether multichannel flow cytometry detection of residual AML on a companion biologic study protocol CCG-B942 predicts outcome, and determine whether any of these treatment regimens eliminates minimal residual disease more effectively than another. - Register all patients with MDS treated or followed at CCG institutions and capture their biologic, historical and outcome data. - Determine, on a companion biologic study protocol CCG-B972, whether levels of IL-2 soluble receptor (sIL-2R) and absolute lymphocyte count (ALC) before, during, and after therapy correlates with outcome. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to center, diagnosis (acute myelogenous leukemia vs other), and response to induction (partial vs complete remission). After induction, patients with M1/M2 marrow are randomized to arm I or II. Patients in complete remission after consolidation who have an HLA-identical or 1-antigen mismatched sibling or parent donor are nonrandomly assigned to the allogeneic bone marrow transplantation (AlBMT) regimen; all others in complete remission are nonrandomly assigned to the Capizzi II regimen, then are randomly assigned to arms III or IV. Patients with refractory anemia (RA) or RA with ringed sideroblasts with indolent disease may be registered and followed. Other patients with myelodysplastic syndromes may receive 2961 chemotherapy or go directly to AlBMT. Patients with chloromas (granulocytic sarcomas) receive optional radiotherapy on arm V. - Patients receive idarubicin IV over 30 minutes on days 0-3, cytarabine and etoposide IV continuously on days 0-3, and oral thioguanine twice a day and oral dexamethasone 3 times a day on days 0-3. Patients then begin course 2, which consists of cytarabine, etoposide, thioguanine, and dexamethasone on days 10-13, daunorubicin IV continuously on days 10-13, and filgrastim (G-CSF) subcutaneously (SC) beginning on day 16 and continuing until blood counts recover. Patients also receive CNS prophylaxis/therapy consisting of cytarabine intrathecally (IT) on days 0 and 14 (if no CNS disease at entry) or on days 0, 5, and 7 (if CNS disease present at entry). Disease is reassessed on day 28-42. Patients with M1 or M2 marrow proceed to consolidation while those with M3 marrow or progressive disease go off study. - Arm I: Patients receive treatment as in induction therapy, plus G-CSF SC beginning on day 16 and continuing until blood counts recover. If CSF is clear by day 10 of induction, patients receive cytarabine IT on days 0, 10, and 35. If CSF is not clear, patients receive triple intrathecal therapy (TIT; cytarabine, hydrocortisone, methotrexate) on days 0 and 10. - Patients receive fludarabine IV over 24 hours on days 0 and 1, cytarabine IV over 72 hours on days 2-4, and idarubicin IV over 15 minutes on days 0-2. G-CSF begins on day 6 and continues until blood counts recover. Patients also receive TIT on days -1 and 7, if CSF is not clear on day 10 of induction. Patients on both arms are reassessed on day 35. Those patients with M1 marrow proceed to intensification; all others are removed from the study. - Capizzi II regimen: Course 1: Patients receive cytarabine IV over 3 hours every 12 hours on days 0, 1, 7, and 8 and asparaginase IM on days 1 and 8. Course 2: Patients also receive cytarabine IT or TIT on days 0, 7, and 14. - Therapy begins within 2-8 weeks of hematologic recovery. Patients may receive interim therapy consisting of oral thioguanine for about 2 weeks. Patients then receive oral busulfan every 6 hours on days -9 to -6 and cyclophosphamide IV over 1 hour on days -5 to -2. AlBMT is infused over 4 hours beginning 36-48 hours after the last dose of cyclophosphamide. Patients in complete remission after completing the Capizzi II regimen proceed to maintenance therapy on arm III. - Arm III: Patients receive interleukin-2 IV continuously on days 1-4 and 9-18. - Arm IV: No further treatment. - Arm V: Patients undergo radiotherapy to the chloroma 5 days a week for 2 weeks. Patients are followed monthly for 18 months, every 3 months for 1 year, and then every 6 months until 5 years from diagnosis. PROJECTED ACCRUAL: Approximately 880 patients with de novo acute myelogenous leukemia will be accrued for this study within 4 years. It is expected that 178 patients per year will be randomly assigned for consolidation, that 39 patients per year will undergo allogeneic bone marrow transplantation while 120 patients per year will receive chemotherapy as intensification, and that 102 patients per year will be randomly assigned for polychemotherapy immunomodulation. An additional 80 patients with myelodysplastic syndromes will be accrued for this study.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: /21 Years
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically confirmed previously untreated acute myeloid leukemia (AML) in patients 1 month to 21 years of age - Infants under 1 month with progressive disease eligible - Supportive care may be given to confirm that the leukemia is not regressing prior to entry - No acute promyelocytic leukemia (FAB M3) - No acute undifferentiated leukemia (FAB M0) - Histochemical verification of AML required by the following stains: - Wright or Giemsa - Peroxidase - PAS - Chloroacetate esterase - Sudan black - Nonspecific esterase (NSE) with and without fluoride (NaF) inhibition - Combined NSE/NaF and butyrate inhibition or diagnosis of megakaryoblastic leukemia (FAB M7) should be supported by one of the following: - CD41 reactivity - Glycoprotein 1b reactivity - Factor VIII-related antigen reactivity - Platelet peroxidase on electron microscopy - The following are also eligible: - Myelodysplastic syndromes, including: - Refractory anemia (RA) * - RA with ringed sideroblasts (RARS) * - RA with excess blasts (RAEB) - RAEB in transformation (RAEBt) - Chronic myelomonocytic leukemia (CMML) - AML with monosomy 7 - Granulocytic sarcoma (chloroma) with or without marrow involvement - Mixed lineage leukemia with 2 morphologically defined populations provided the predominant population is myeloid - No Downs syndrome - No juvenile chronic myelogenous leukemia - No Fanconi's anemia - No secondary AML NOTE: * RA and RARS may be registered and observed until treatment deemed necessary PATIENT CHARACTERISTICS: Age: - Under 22 Performance status: - Not specified Life expectancy: - Not specified Hematopoeitic: - Not specified Hepatic: - Not specified Renal: - Not specified PRIOR CONCURRENT THERAPY: Biologic therapy: - Not specified Chemotherapy: - No prior anticancer chemotherapy Endocrine therapy: - Prior topical or inhaled steroids for nonmalignant conditions allowed Radiotherapy : - No prior anticancer radiotherapy Surgery: - Not specified Other: - No prior antileukemic therapy
Total Enrollment:
Location and Contact Information:
Overall Study Official:
BeverlyLange, Study Chair, Children's Hospital of Philadelphia
State University of New York Health Science Center at Brooklyn College of Medicine
Brooklyn, New York, 11203
United States
New York Presbyterian Hospital - Cornell Campus
New York City, New York, 10021-4885
United States
Nemours Children's Clinic
Jacksonville, Florida, 32207
United States
Inova Fairfax Hospital
Falls Church, Virginia, 22042-3300
United States
Emory University Hospital - Atlanta
Atlanta, Georgia, 30322
United States
Royal Children's Hospital
Brisbane, Queensland, 4029
Australia
Cedars-Sinai Medical Center
Los Angeles, California, 90048
United States
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601
United States
Michigan State University
East Lansing, Michigan, 48824
United States
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, 44195
United States
Roswell Park Cancer Institute
Buffalo, New York, 14263-0001
United States
East Tennessee Children's Hospital
Knoxville, Tennessee, 37901
United States
Children's Hospital of Oakland
Oakland, California, 94609-1809
United States
Children's Memorial Hospital, Chicago
Chicago, Illinois, 60614
United States
Methodist Health Care System
San Antonio, Texas, 78229-3902
United States
Simmons Cancer Center - Dallas
Dallas, Texas, 75235-9154
United States
Tampa Children's Hospital
Tampa, Florida, 33677-4227
United States
Children's National Medical Center
Washington D.C., District of Columbia, 20010-2970
United States
Schneider Children's Hospital
New Hyde Park, New York, 11042
United States
Hurley Medical Center
Flint, Michigan, 48503
United States
Ireland Cancer Center
Cleveland, Ohio, 44106-5065
United States
Southern Illinois University School of Medicine
Springfield, Illinois, 62794-9658
United States
William Beaumont Hospital
Royal Oak, Michigan, 48073-6769
United States
Avera Cancer Institute
Sioux Falls, South Dakota, 57105-1080
United States
Brooklyn Hospital Center
Brooklyn, New York, 11201
United States
Natalie Warren Bryant Cancer Center
Tulsa, Oklahoma, 74136
United States
Medical Center of Central Georgia
Macon, Georgia, 31201
United States
Children's Hospital of Austin
Austin, Texas, 78701
United States
Children's Hospital
Hamilton, Ontario, L8N 3Z5
Canada
Arizona Cancer Center
Tucson, Arizona, 85724
United States
Atlantic Health System
Summit, New Jersey, 07901
United States
University of Mississippi Medical Center
Jackson, Mississippi, 39216-4505
United States
Covenant Children's Hospital
Lubbock, Texas, 79410
United States
Baylor College of Medicine
Houston, Texas, 77030
United States
Presbyterian-St Luke's Medical Center
Denver, Colorado, 80218
United States
St. Mary's/Duluth Clinic Cancer Center
Duluth, Minnesota, 55805-1983
United States
Marlene and Stewart Greenebaum Cancer Center, University of Maryland
Baltimore, Maryland, 21201-1595
United States
Hopital Sainte Justine
Montreal, Quebec, H3T 1C5
Canada
Loma Linda University Medical Center
Loma Linda, California, 92354
United States
Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109-1024
United States
Princess Margaret Hospital for Children
Perth, Western Australia, 6001
Australia
Baystate Medical Center
Springfield, Massachusetts, 01107
United States
Albert B. Chandler Medical Center, University of Kentucky
Lexington, Kentucky, 40536-0284
United States
David Grant Medical Center
Travis Air Force Base, California, 94535
United States
Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033-0850
United States
All Children's Hospital
St. Petersburg, Florida, 33701
United States
Massey Cancer Center
Richmond, Virginia, 23298-0037
United States
University of Nebraska Medical Center
Omaha, Nebraska, 68198-2168
United States
Tripler Army Medical Center
Honolulu, Hawaii, 96859-5000
United States
Hospital for Sick Children
Toronto, Ontario, M5G 1X8
Canada
Kosair Children's Hospital
Louisville, Kentucky, 40202-3830
United States
Medical College of Georgia Comprehensive Cancer Center
Augusta, Georgia, 30912-4000
United States
Children's Hospital of Oklahoma
Oklahoma City, Oklahoma, 73104
United States
Cook Children's Medical Center - Fort Worth
Ft. Worth, Texas, 76104
United States
Deaconess Medical Center
Spokane, Washington, 99210-0248
United States
Sunrise Hospital and Medical Center
Las Vegas, Nevada, 89109-2306
United States
Centre Hospitalier de L'Universite Laval
Sainte-Foy, Quebec, GIV 4G2
Canada
St. Mary's Hospital
West Palm Beach, Florida, 33407
United States
Children's Hospital of Columbus
Columbus, Ohio, 43205-2696
United States
Children's Hospital and Health Center
San Diego, California, 92123-4282
United States
Rhode Island Hospital
Providence, Rhode Island, 02818
United States
Broward General Medical Center
Ft. Lauderdale, Florida, 33316
United States
Children's Hospital Los Angeles
Los Angeles, California, 90027-0700
United States
Children's Hospital of Omaha
Omaha, Nebraska, 68114
United States
Dakota Cancer Institute
Fargo, North Dakota, 58103-4940
United States
James P. Wilmot Cancer Center
Rochester, New York, 14642
United States
Royal Children's Hospital
Parkville, Victoria, 3052
Australia
Swiss Pediatric Oncology Group Bern
BERN, , CH 3010
Switzerland
Children's Hospital of Western Ontario
London, Ontario, N6C 2V5
Canada
Tulane University School of Medicine
New Orleans, Louisiana, 70112
United States
Phoenix Children's Hospital
Phoenix, Arizona, 85016-7710
United States
Doernbecher Children's Hospital
Portland, Oregon, 97201-3098
United States
Naval Medical Center, Portsmouth
Portsmouth, Virginia, 23708-5100
United States
Miami Children's Hospital
Miami, Florida, 33155-4069
United States
Swiss Pediatric Oncology Group Geneva
Geneva, , CH 1211
Switzerland
Ochsner Clinic
New Orleans, Louisiana, 70121
United States
University of Puerto Rico School of Medicine Medical Sciences Campus
San Juan, , 00936-5067
Puerto Rico
Children's Hospital Central California
Madera, California, 93638-8762
United States
Brookdale University Hospital and Medical Center
Brooklyn, New York, 11212
United States
University of South Alabama Medical Center
Mobile, Alabama, 36604
United States
Laval University Medical Center
Sainte-Foy, Quebec, G1V 4G2
Canada
Henry Ford Hospital
Detroit, Michigan, 48202
United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78207
United States
Alfred I. Dupont Institute
Wilmington, Delaware, 19899
United States
Alberta Children's Hospital
Calgary, Alberta, T2T 5C7
Canada
Memorial Sloan-Kettering Cancer Center
New York City, New York, 10021
United States
Janeway Children's Health and Rehabilitation Centre
St. John's, Newfoundland and Labrador, A1B 3V6
Canada
Carolinas Medical Center
Charlotte, North Carolina, 28232-2861
United States
Geisinger Medical Center
Danville, Pennsylvania, 17822-1320
United States
University of Miami-Jackson Memorial Hospital
Miami, Florida, 33136
United States
Saint Jude Children's Research Hospital
Memphis, Tennessee, 38105-2794
United States
Yale Comprehensive Cancer Center
New Haven, Connecticut, 06520-8028
United States
Swiss Pediatric Oncology Group Lausanne
Lausanne, , CH 1011
Switzerland
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, 95051-5386
United States
Medical City Dallas Hospital
Dallas, Texas, 75230
United States
San Jorge Childrens Hospital
Santurce, , 00912
Puerto Rico
St. Vincent Hospital and Health Care Center
Indianapolis, Indiana, 46260
United States
Walter Reed Army Medical Center
Washington D.C., District of Columbia, 20307-5000
United States
Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15213
United States
Children's Medical Center - Dayton
Dayton, Ohio, 45404
United States
Children's Hospitals and Clinics of Minnesota
St. Paul, Minnesota, 55102
United States
Duke Comprehensive Cancer Center
Durham, North Carolina, 27710
United States
Sutter Cancer Center
Sacramento, California, 95816
United States
Forum Health-Tod Childrens Hospital
Youngstown, Ohio, 44501
United States
British Columbia Children's Hospital
Vancouver, British Columbia, V6H 3V4
Canada
Children's Mercy Hospital
Kansas City, Missouri, 64108
United States
Lineberger Comprehensive Cancer Center, UNC
Chapel Hill, North Carolina, 27599-7295
United States
Cancer Center at the University of Virginia
Charlottesville, Virginia, 22908
United States
Children's Hospital Medical Center - Cincinnati
Cincinnati, Ohio, 45229-2899
United States
Midwest Children's Cancer Center
Milwaukee, Wisconsin, 53226
United States
Lombardi Cancer Center
Washington D.C., District of Columbia, 20007
United States
Sioux Valley Hospital
Sioux Falls, South Dakota, 57117
United States
Group Health Cooperative of Puget Sound
Seattle, Washington, 98112
United States
Marshfield Clinic
Marshfield, Wisconsin, 54449-5772
United States
Newark Beth Israel Medical Center
Newark, New Jersey, 07112-2094
United States
St. Vincent Hospital
Green Bay, Wisconsin, 54307-9070
United States
Lucile Packard Children's Hospital at Stanford
Palo Alto, California, 94304
United States
Kaiser Permanente Medical Group - San Francisco
San Francisco, California, 94115
United States
Children's Hospital at Westmead
Westmead, New South Wales, 2145
Australia
St. Christopher's Hospital for Children
Philadelphia, Pennsylvania, 19134-1095
United States
Cross Cancer Institute
Edmonton, Alberta, T6G 1Z2
Canada
Mary Bridge Children's Health Center
Tacoma, Washington, 98415-0299
United States
Women's and Children's Hospital
North Adelaide, South Australia, 5006
Australia
St. Louis Children's Hospital
St. Louis, Missouri, 63110
United States
Mission Saint Joseph's Health System
Asheville, North Carolina, 28801
United States
James H. Quillen College of Medicine
Johnson City, Tennessee, 37614-0622
United States
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, S7N 4H4
Canada
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104
United States
University of California San Diego Cancer Center
La Jolla, California, 92103-8447
United States
IWK Health Centre
Halifax, Nova Scotia, B3J 3G9
Canada
UCSF Cancer Center and Cancer Research Institute
San Francisco, California, 94143-0128
United States
University of Connecticut Health Center
Farmington, Connecticut, 06360-7106
United States
CancerCare Manitoba
Winnipeg, Manitoba, R3E 0V9
Canada
Joe DiMaggio Children's Hospital at Memorial
Hollywood, Florida, 33021
United States
Florida Hospital Cancer Institute
Orlando, Florida, 32803
United States
Children's Hospital and Regional Medical Center - Seattle
Seattle, Washington, 98105
United States
Maimonides Medical Center
Brooklyn, New York, 11219
United States
Kaiser Permanente-Southern California Permanente Medical Group
San Diego, California, 92120
United States
Hackensack University Medical Center
Hackensack, New Jersey, 07601
United States
Allan Blair Cancer Centre
Regina, Saskatchewan, S4T 7T1
Canada
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, 21231-2410
United States
St. Vincent Mercy Medical Center
Toledo, Ohio, 43608
United States
Children's Hospital of the King's Daughters
Norfolk, Virginia, 23507
United States
Children's Hospital of Denver
Denver, Colorado, 80218-1088
United States
Children's Hospital of Southwest Florida
Ft. Myers, Florida, 33908
United States
Spectrum Health and DeVos Children's Hospital
Grand Rapids, Michigan, 49503
United States
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, 37232-6838
United States
Cabell-Huntington Hospital, Inc
Huntington, West Virginia, 25701
United States
Santa Barbara Cottage Hospital
Santa Barbara, California, 93102
United States
Children's Hospital of Michigan
Detroit, Michigan, 48201
United States
Dana-Farber Cancer Institute
Boston, Massachusetts, 02115
United States
Carilion Roanoke Community Hospital
Roanoke, Virginia, 24013
United States
Cardinal Glennon Children's Hospital
St. Louis, Missouri, 63104
United States
Columbia Presbyterian Hospital
New York City, New York, 10032
United States
Rush-Presbyterian-St. Luke's Medical Center
Chicago, Illinois, 60612
United States
Bellin Memorial Hospital
Green Bay, Wisconsin, 54301
United States
Maine Children's Cancer Program
Scarborough, Maine, 04074
United States
Floating Hospital for Children
Boston, Massachusetts, 02111
United States
State University of New York - Upstate Medical University
Syracuse, New York, 13210
United States
University of Texas - MD Anderson Cancer Center
Houston, Texas, 77030-4009
United States
Mount Sinai School of Medicine
New York City, New York, 10029
United States
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, 90095-1781
United States
Indiana University Cancer Center
Indianapolis, Indiana, 46202-5289
United States
New York Medical College
Valhalla, New York, 10595
United States
St. Joseph's Hospital and Medical Center
Paterson, New Jersey, 07503
United States
Medical University of South Carolina
Charleston, South Carolina, 29425-0721
United States
Vermont Cancer Center
Burlington, Vermont, 05401-3498
United States
University of Chicago Cancer Research Center
Chicago, Illinois, 60601
United States
Mott Children's Hospital
Ann Arbor, Michigan, 48109-0914
United States
University of Wisconsin Hospital and Clinics
Madison, Wisconsin, 53792-0001
United States
CCOP - Green Bay
Green Bay, Wisconsin, 54301
United States
Children's Hospital of Orange County
Orange, California, 92868
United States
Sydney Children's Hospital
Randwick, New South Wales, 2031
Australia
Cancer Center and Beckman Research Institute, City of Hope
Duarte, California, 91010-3000
United States
Eastern Maine Medical Center
Bangor, Maine, 04401
United States
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007
United States
Baptist Hospital of Miami
Miami, Florida, 33176-2197
United States
North Shore University Hospital
Manhasset, New York, 11030
United States
East Carolina University School of Medicine
Greenville, North Carolina, 27858-4354
United States
Chao Family Comprehensive Cancer Center
Orange, California, 92868
United States
Cancer Research Center of Hawaii
Honolulu, Hawaii, 96813
United States
Children's Hospitals and Clinics - Minneapolis
Minneapolis, Minnesota, 55404
United States
Nemours Children's Clinic-Orlando
Orlando, Florida, 32806
United States
University of New Mexico Cancer Research and Treatment Center
Albuquerque, New Mexico, 87131
United States
Mayo Clinic Cancer Center
Rochester, Minnesota, 55905
United States
Cancer Center of Albany Medical Center
Albany, New York, 12208
United States
Legacy Emanuel Hospital and Health Center
Portland, Oregon, 97227
United States
Madigan Army Medical Center
Tacoma, Washington, 98431-5000
United States
Childhood Hematology/Oncology Associates
Denver, Colorado, 80218
United States
University of California Davis Medical Center
Sacramento, California, 95817
United States
Montefiore Medical Center
Bronx, New York, 10467-2490
United States
Comprehensive Cancer Center at Wake Forest University
Winston Salem, North Carolina, 27157-1081
United States
Norris Cotton Cancer Center
Lebanon, New Hampshire, 03756-0002
United States
Hope Children's Hospital
Oak Lawn, Illinois, 60453
United States
Children's Hospital of New Orleans
New Orleans, Louisiana, 70118
United States
Sinai Hospital of Baltimore
Baltimore, Maryland, 21225
United States
McGill University Health Center - Montreal Children's Hospital
Montreal, Quebec, H3H 1P3
Canada
St. John Hospital and Medical Center
Detroit, Michigan, 48236
United States
Toledo Children's Hospital
Toledo, Ohio, 43601
United States
Saint Jude Midwest Affiliate
Peoria, Illinois, 61637
United States
Children's Healthcare of Atlanta - Scottish Rite
Atlanta, Georgia, 30342
United States
Children's Hospital Medical Center of Akron
Akron, Ohio, 44308
United States
Shands Hospital and Clinics, University of Florida
Gainesville, Florida, 32610-100277
United States
Mountain States Tumor Institute
Boise, Idaho, 83712
United States
Children's Hospital of Eastern Ontario
Ottawa, Ontario, K1H 8L1
Canada
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
United States
Children's Hospital of Greenville Hospital System
Greenville, South Carolina, 29605
United States
Texas Tech University Health Sciences Center School of Medicine
Amarillo, Texas, 79106
United States
Jonathan Jaques Children's Cancer Center
Long Beach, California, 90801-1428
United States
State University of New York Health Sciences Center - Stony Brook
Stony Brook, New York, 11790-7775
United States
Southern California Permanente Medical Group
Downey, California, 90242
United States
Scott and White Memorial Hospital
Temple, Texas, 76508
United States
West Virginia University - Charleston
Charleston, West Virginia, 25302
United States
University of Texas Medical Branch
Galveston, Texas, 77555-0361
United States
Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242-1009
United States
Lutheran General Hospital
Park Ridge, Illinois, 60068-1174
United States
San Antonio Military Pediatric Cancer and Blood Disorders Center
Lackland Air Force Base, Texas, 78236-5300
United States
Palmetto Health South Carolina Cancer Center
Columbia, South Carolina, 29203
United States
Raymond Blank Memorial Hospital for Children
Des Moines, Iowa, 50309
United States
Presbyterian Healthcare
Charlotte, North Carolina, 28233-3549
United States
West Virginia University Hospitals
Morgantown, West Virginia, 26506-9300
United States
University of Alabama at Birmingham Comprehensive Cancer Center
Birmingham, Alabama, 35233
United States
University of Illinois at Chicago
Chicago, Illinois, 60612
United States
Wesley Medical Center
Wichita, Kansas, 67214
United States
Sacred Heart Children's Hospital
Pensacola, Florida, 32504
United States
Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903
United States
Starship Children's Hospital
Auckland, ,
New Zealand
Huntsman Cancer Institute
Salt Lake City, Utah, 84112
United States
University of Massachusetts Memorial Medical Center - University Campus
Worcester, Massachusetts, 01655
United States
Academisch Ziekenhuis Groningen
Groningen, , 9700 RB
Netherlands
Memorial Health University Medical Center, Inc.
Savannah, Georgia, 31403-3089
United States
Additional Information:
Study ID Numbers: CDR0000064883; COG-2961,CCG-2961
Study Start Date:
Record last reviewed: February 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002798
Other Refractory Anemia Studies:
1. Interleukin-12 in Treating Patients With Previously Treated Non-Hodgkin's Lymphoma or Hodgkin's Disease
2. Monoclonal Antibody Therapy, Chemotherapy, and Peripheral Stem Cell Transplantation in Treating Patients With Refractory Non-Hodgkin's Lymphoma
3. Cytarabine and Daunorubicin in Treating Older Patients With Acute Myeloid Leukemia
4. Irinotecan and Cytarabine in Treating Patients With Refractory or Recurrent Acute Myeloid Leukemia or Chronic Myelogenous Leukemia
5. HLA-Mismatched Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Hematological Malignancies
Related Studies:
Other Refractory Anemia Clinical Trials
Other Texas Clinical Trials
Other Houston Clinical Trials
Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome
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