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Combination Chemotherapy Followed by Radiation Therapy in Treating Children With Localized Ependymoma Clinical Trials Resources presented on Clinical Trials Search is not meant to be a substitute for proven health advice, calls or treatment with a real medical. We aren't mDs. Always consult your doctor on Combination Chemotherapy Followed by Radiation Therapy in Treating Children With Localized Ependymoma conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Combination Chemotherapy Followed by Radiation Therapy in Treating Children With Localized Ependymoma Clinical research trials and Combination Chemotherapy Followed by Radiation Therapy in Treating Children With Localized Ependymoma healthcare trials take place in a lot of of localities throughout the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically assess the effectiveness of new does drugs. The function of the studies / projects is to figure out specific human medical questions. Clinical trials are a popular means for doctors, government agencies, and private sector corporations to find cures for all varieties of conditions, like Combination Chemotherapy Followed by Radiation Therapy in Treating Children With Localized Ependymoma. Combination Chemotherapy Followed by Radiation Therapy in Treating Children With Localized Ependymoma Clinical Trials and other clinical trials allow volunteers to access health treatment options before they are available to the masses. Many times the subjects receive professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Combination Chemotherapy Followed by Radiation Therapy in Treating Children With Localized Ependymoma clinical trial. Human subjects often obtain the finest healthcare possible for their Combination Chemotherapy Followed by Radiation Therapy in Treating Children With Localized Ependymoma condition. Hazards are a reality, nevertheless, and might include additional or frequent dr. calls, health hazards (potentially life-jeopardizing), and/or the treatment being uneffective. Trials are federally regulated with stern guidelines to protect clinical trials patients.
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Home > "C" Clinical Trials Conditions > Combination Chemotherapy Followed by Radiation Therapy in Treating Children With Localized Ependymoma  Combination Chemotherapy Followed by Radiation Therapy in Treating Children With Localized Ependymoma
Combination Chemotherapy Followed by Radiation Therapy in Treating Children With Localized Ependymoma
For Condition: childhood supratentorial ependymoma,newly diagnosed childhood ependymoma,childhood infratentorial ependymoma
Status: Recruiting
Sponsor(s): Societe Internationale d'Oncologie Pediatrique , United Kingdom Children's Cancer Study Group,Associazone Italiana Ematologia Oncologia Pediatrica
Synopsis: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one drug and combining chemotherapy with radiation therapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy followed by radiation therapy in treating children who have localizedependymoma.
Details: OBJECTIVES: - Determine the event free and overall survival of children with incompletely resected localized ependymoma when treated with adjuvant cyclophosphamide, etoposide, and vincristine followed by radiotherapy. - Determine the response rate in these patients to this regimen. OUTLINE: This is a multicenter study. Patients undergo surgery to remove as much of tumor as possible. Patients with residual disease proceed to chemotherapy, while those with no residual disease proceed directly to radiotherapy. Chemotherapy begins within 3 weeks of surgery and consists of vincristine IV on days 1, 8, and 15, cyclophosphamide IV over 3 hours on day 1, and etoposide IV over 4 hours on days 1-3. Treatment repeats every 4 weeks for up to 4 courses. Patients who progress after 2 courses proceed to radiotherapy. If residual disease is still present at completion of chemotherapy, second look surgery is recommended. Patients undergo radiotherapy daily for 6 weeks beginning after complete resection within 4 weeks of surgery, within 3 weeks of completion of chemotherapy, or within 4 weeks of second look surgery. Patients are followed at 6 weeks after radiotherapy, every 2 months for 1 year, every 4 months for 2 years, every 6 months for 2 years, and then annually for 5 years. PROJECTED ACCRUAL: A total of 65 patients will be accrued for this study within 2-3 years.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: 3 Years/20 Years
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically proven nonmetastatic intracranial ependymoma - Cellular - Papillary - Clear cell - Mixed cell - Anaplastic - No myxopapillary ependymoma, subependymoma, or ependymoblastoma PATIENT CHARACTERISTICS: Age: - 3 to 20 Performance status: - Not specified Life expectancy: - Not specified Hematopoietic: - No hematologic disease that would preclude study participation Hepatic: - Not specified Renal: - No renal disease that would preclude study participation Other: - No concurrent unrelated disease that would preclude study participation PRIOR CONCURRENT THERAPY: Biologic therapy: - Not specified Chemotherapy: - No prior chemotherapy Endocrine therapy: - Prior steroids allowed Radiotherapy: - No prior radiotherapy Surgery: - Not specified
Total Enrollment:
Location and Contact Information:
Overall Study Official:
RichardGrundy, Study Chair, Birmingham Children's Hospital
Aberdeen Royal Infirmary *Recruiting*
Aberdeen, Scotland, AB25 2ZN
United Kingdom
Recruiting D.J. King 44-1224-681-818
Queen's Medical Centre *Recruiting*
Nottingham, England, NG7 2UH
United Kingdom
Recruiting David Walker 44-115-924-9924
Royal Liverpool Children's Hospital, Alder Hey *Recruiting*
Liverpool, England, L12 2AP
United Kingdom
Recruiting Heather McDowell 44-151-228-4811
Manchester Children's Hospitals (NHS Trust) *Recruiting*
Manchester, England, M27 1HA
United Kingdom
Recruiting Bernadette Brennan 44-161-727-2222
Istituto Nazionale per lo Studio e la Cura dei Tumori *Recruiting*
Milano (Milan), , 20133
Italy
Recruiting Maura Massimino 39-02-239-02593
Oxford Radcliffe Hospital *Recruiting*
Oxford, England, 0X3 9DU
United Kingdom
Recruiting Kate Wheeler 44-186-522-1066
Children's Hospital - Sheffield *Recruiting*
Sheffield, England, S10 2TH
United Kingdom
Recruiting Mary Gerrard 00-44-0114-271-7229
Royal Belfast Hospital for Sick Children *Recruiting*
Belfast, Northern Ireland, BT12 6BE
United Kingdom
Recruiting Anthony Mccarthy 44-289-063-3631
Meyerstein Institute of Oncology at Middlesex Hospital *Recruiting*
London, England, WIT 3AA
United Kingdom
Recruiting Maria Michelagnoli 44-20-7380-9950
Royal Hospital for Sick Children *Recruiting*
Edinburgh, Scotland,
United Kingdom
Recruiting Hamish Wallace 0131-536-0426
Great Ormond Street Hospital for Children NHS Trust *Recruiting*
London, England, WC1N 3JH
United Kingdom
Recruiting Penelope Brock 44-20-829-8832
Hospital for Sick Children *Recruiting*
Toronto, Ontario, M5G 1X8
Canada
Recruiting Eric Bouffet 416-813-7457
Newcastle Upon Tyne Hospitals NHS Trust *Recruiting*
Newcastle upon Tyne, England, NE7 7DN
United Kingdom
Recruiting Andrew J. Pearson 44-191-232-5131 ext. 24101
Rigshospitalet *Recruiting*
Copenhagen, , 2100
Denmark
Recruiting H. Carstensen 45-35451367
Ostra Sjukhuset *Recruiting*
Goteborg, , 41685
Sweden
Recruiting Brigitta Lannering 46-31-343-5224
Saint Bartholomew's Hospital *Recruiting*
London, England, EC1A 7BE
United Kingdom
Recruiting Judith Kingston 44-20-7943-1339
Our Lady's Hospital for Sick Children *Recruiting*
Crumlin, , 12
Ireland
Recruiting Fin Breatnach 353-1-409-6659
Southampton General Hospital *Recruiting*
Southampton, England, SO16 6YD
United Kingdom
Recruiting Janice Kohler 170-379-6942
Sophia Children's Hospital *Recruiting*
Rotterdam, , 3015 GJ
Netherlands
Recruiting R. Reddingius 31-10-463-6363
Addenbrooke's NHS Trust *Recruiting*
Cambridge, England, CB2 2QQ
United Kingdom
Recruiting Denise Williams 44-1223-216-878
Bristol Royal Hospital for Children *Recruiting*
Bristol, England, BS2 8BJ
United Kingdom
Recruiting Annabel Foot 44-117-921-5411
Fundacion para la Lucha contra las Enfermedades Neurologicas de la Infancia *Recruiting*
Buenos Aires, , 1428
Argentina
Recruiting Blanca Diez 5411-5777-3200
Leicester Royal Infirmary *Recruiting*
Leicester, England, LE1 5WW
United Kingdom
Recruiting Rosemary Shannon 44-116-254-1414
Royal Marsden Hospital - Sutton *Recruiting*
Sutton, England, SM2 5PT
United Kingdom
Recruiting Kathy Pritchard-Jones 44-20-8661-3496
St. James's University Hospital *Recruiting*
Leeds, England, LS9 7TF
United Kingdom
Recruiting Adam Glaser 44-113-206-4986
Hospital Des Cruces *Recruiting*
Vizcaya, , 48
Spain
Recruiting Aurora Navajas 34-94-600-6000
Royal Hospital for Sick Children *Recruiting*
Glasgow, Scotland, G3 8SJ
United Kingdom
Recruiting E.M. Simpson 44-141-201-0000
Birmingham Children's Hospital *Recruiting*
Birmingham, England, B4 6NH
United Kingdom
Recruiting Bruce Morland 44-121-333-8233
Additional Information:
Study ID Numbers: CDR0000067465; SIOP-EPENDYMOMA-99,AIEOP-EPENDYMOMA-99,UKCCSG-EPENDYMOMA-99,EU-99001
Study Start Date:
Record last reviewed: April 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004224
Other Childhood Supratentorial Ependymoma Studies:
1. Combination Chemotherapy Followed by Radiation Therapy in Treating Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma
2. Genetic Study of Newly Diagnosed Central Nervous System Tumors in Young Children
3. Combination Chemotherapy in Treating Children With Astrocytomas and Primitive Neuroectodermal Tumors
4. Observation or Radiation Therapy and/or Chemotherapy and Second Surgery in Treating Children Who Have Undergone Surgery for Ependymoma
5. Antineoplaston Therapy in Treating Patients With Ependymoma
Related Studies:
Other childhood supratentorial ependymoma Clinical Trials
Other Scotland Clinical Trials
Other Edinburgh Clinical Trials
Combination Chemotherapy Followed by Radiation Therapy in Treating Children With Localized Ependymoma
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