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Combination Chemotherapy Before Surgery in Treating Children With Localized Neuroblastoma Clinical Trials Facts presented on Clinical Trials Search is not designed to be a substitute for certified medical advice, travels to or treatment with a real dr.. We aren't doctors. Always consult your mD on Combination Chemotherapy Before Surgery in Treating Children With Localized Neuroblastoma conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Combination Chemotherapy Before Surgery in Treating Children With Localized Neuroblastoma Clinical research trials and Combination Chemotherapy Before Surgery in Treating Children With Localized Neuroblastoma medical trials occur in many of places across the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectiveness of new does drugs. The role of the studies / undertakings is to figure out certain human healthcare questions. Clinical trials are a popular means for doctors, government agencies, and private sector corporations to locate treatments for all forms of circumstances, including Combination Chemotherapy Before Surgery in Treating Children With Localized Neuroblastoma. Combination Chemotherapy Before Surgery in Treating Children With Localized Neuroblastoma Clinical Trials and other clinical trials permit volunteers to get medical treatment options before they are available to the masses. Most times the human subjects acquire treatment for free of charge, and sometimes they are paid for their time. Occasionally there is a cost for a Combination Chemotherapy Before Surgery in Treating Children With Localized Neuroblastoma clinical trial. Participants oftentimes recieve the finest healthcare available for their Combination Chemotherapy Before Surgery in Treating Children With Localized Neuroblastoma condition. Dangers are a reality, nonetheless, and might include extra or frequent physician calls, health hazards (potentially life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.
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Home > "C" Clinical Trials Conditions > Combination Chemotherapy Before Surgery in Treating Children With Localized Neuroblastoma  Combination Chemotherapy Before Surgery in Treating Children With Localized Neuroblastoma
Combination Chemotherapy Before Surgery in Treating Children With Localized Neuroblastoma
For Condition: localized unresectable neuroblastoma
Status: Recruiting
Sponsor(s): Societe Internationale d'Oncologie Pediatrique , United Kingdom Children's Cancer Study Group
Synopsis: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy drugs before surgery may shrink the tumor so that it can be removed during surgery. PURPOSE: Phase III trial to determine the effectiveness of combination chemotherapy given before surgery in treating children who have localizedneuroblastoma.
Details: OBJECTIVES: - Determine the outcome, in terms of local control, event-free survival, and overall survival, of children with localized unresectable neuroblastoma without MYCN amplification treated with carboplatin, etoposide, cyclophosphamide, doxorubicin, and vincristine followed by surgery. OUTLINE: This is a multicenter study. Patients receive carboplatin IV over 1 hour and etoposide IV over 2 hours on days 1-3 (courses 1 and 3). Patients receive cyclophosphamide IV over 1 hour on days 1-5 (or orally on days 2 and 3), doxorubicin IV over 6 hours on days 4-5, and vincristine IV on days 1 and 5 (courses 2 and 4). Treatment repeats every 21 days for 4 courses. Patients then undergo surgical resection followed by 2 additional courses of chemotherapy. Patients are followed at months 8, 10, 12, 16, 20, 24, 30, 36, 42, 48, and 60. PROJECTED ACCRUAL: A total of 100 patients will be accrued for this study within 4 years.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: 1 Year/18 Years
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Diagnosis of localized unresectable neuroblastoma - Stage II or III - No MYCN amplification PATIENT CHARACTERISTICS: Age: - Over 1 Performance status: - Not specified Life expectancy: - Not specified Hematopoietic: - Not specified Hepatic: - Not specified Renal: - Not specified PRIOR CONCURRENT THERAPY: Biologic therapy: - Not specified Chemotherapy: - No prior chemotherapy Endocrine therapy: - Not specified Radiotherapy: - No prior radiotherapy Surgery: - Not specified
Total Enrollment:
Location and Contact Information:
Overall Study Official:
JaniceKohler, Study Chair, Southampton General Hospital
Odense University Hospital *Recruiting*
Odense, , DK-5000
Denmark
Recruiting N. Carlsen 45-6-611-3333
Centre Hospitalier Universitaire Vaudois *Recruiting*
Lausanne, , CH-1011
Switzerland
Recruiting Maja Popovic 41-21-314-3567
Southampton General Hospital *Recruiting*
Southampton, England, SO16 6YD
United Kingdom
Recruiting Janice Kohler 170-379-6942
Istituto Giannina Gaslini *Recruiting*
Genova, , 16148
Italy
Recruiting Alberto Garaventa 39-010-563-6714
Centre Hospitalier Regional de Purpan *Recruiting*
Toulouse, , 31026
France
Recruiting Herve Rubie 33-5-61-491-133
Children's Hospital *Recruiting*
Cologne, , D-50924
Germany
Recruiting Frank Berthold 49-221-478-4380
Ostra Sjukhuset *Recruiting*
Goteborg, , 41685
Sweden
Recruiting Ildiko Marky 46-31-343-4663
Hospital Universitario LA FE *Recruiting*
Valencia, , 46009
Spain
Recruiting Victoria Castel 34-96-386-2700
Universitair Ziekenhuis Gent *Recruiting*
Ghent, , B-9000
Belgium
Recruiting Genevieve Laureys 32-9-240-21-11
St. Anna Children's Hospital *Recruiting*
Vienna, , A-1090
Austria
Recruiting Ruth Ladenstein 43 1 40470 0
Instituto Portugues de Oncologia de Francisco Gentil - Centro de Lisboa *Recruiting*
Lisboa, , 1099-023 Codex
Portugal
Recruiting Ana De Lacerda 351-21-726-0429
National Hospital Oslo University *Recruiting*
Oslo, , 0027
Norway
Recruiting Ingebjorg Storm-Mathisen 47-23-07-45-60
Additional Information:
Study ID Numbers: CDR0000068960; EU-20107,SIOP-NB-2009,UKCCSG-NB-2000-09
Study Start Date:
Record last reviewed: September 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00025428
Other Localized Unresectable Neuroblastoma Studies:
1. Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Neuroblastoma
2. Antineoplaston Therapy in Treating Patients With Metastatic, Recurrent, or Refractory Neuroblastoma
3. Combination Chemotherapy Before Surgery in Treating Children With Localized Neuroblastoma
4. Combination Chemotherapy With or Without Filgrastim Before Surgery, High-Dose Chemotherapy, and Radiation Therapy Followed by Isotretinoin With or Without Monoclonal Antibody in Treating Patients With Neuroblastoma
5. Combination Chemotherapy, Radiation Therapy, and Stem Cell Transplantation in Treating Patients With Neuroblastoma
Related Studies:
Other localized unresectable neuroblastoma Clinical Trials
Other Clinical Trials
Other Goteborg Clinical Trials
Combination Chemotherapy Before Surgery in Treating Children With Localized Neuroblastoma
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