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Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for certified medical advice, calls or professional assistance using a genuine dr.. We aren't physicians. Always confer with your dr. on Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia Clinical research trials and Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia medical trials happen in hundreds of localities throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new does drugs. The intent of the studies / undertakings is to answer particular human health questions. Clinical trials are a popular manner for physicians, government agencies, and private sector corporations to find cures for all kinds of circumstances, like Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia. Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia Clinical Trials and other clinical trials permit volunteers to acquire healthcare treatment options before they are available to the general public. Some times the subjects acquire professional assistance for free, and sometimes they are paid for their time. Sometimes there is a cost for a Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia clinical trial. Participants frequently obtain the most expert healthcare available for their Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia condition. Dangers are a reality, nevertheless, and can include more or frequent doctor calls, health risks (potentially life-jeopardizing), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.
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Home > "C" Clinical Trials Conditions > Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia  Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia
Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia
For Condition: recurrent childhood small noncleaved cell lymphoma,recurrent childhood acute lymphoblastic leukemia,recurrent childhood large cell lymphoma,B-cell childhood acute lymphoblastic leukemia,childhood immunoblastic large cell lymphoma,childhood diffuse large cell lymphoma
Status: Recruiting
Sponsor(s): Children's Oncology Group , National Cancer Institute (NCI)
Synopsis: RATIONALE: Chemotherapy drugs such as ifosfamide, carboplatin, and etoposide use different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies such as rituximab can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. Combining ifosfamide, carboplatin, and etoposide with rituximab may kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of combining ifosfamide, carboplatin, and etoposide with rituximab in treating young patients who have recurrent or refractorynon-Hodgkin's lymphoma or acute lymphoblastic leukemia.
Details: OBJECTIVES: - Determine the response of pediatric patients with relapsed or refractory B-cell non-Hodgkin's lymphoma or acute lymphoblastic leukemia treated with ifosfamide, carboplatin, and etoposide combined with rituximab. - Determine the relapse-free survival rate of patients treated with this regimen. - Determine the toxicity profile of this regimen in these patients, specifically the frequency of therapy delays between courses due to prolonged grade IV hematologic toxicity. - Determine whether this regimen plus filgrastim (G-CSF) will result in mobilization of greater than 2 X 10^6/kg peripheral blood stem cells (CD34+ cells, PBSC) in at least 80% of patients for whom peripheral stem cell collection is performed. - Determine the time course of engraftment for patients who undergo peripheral stem cell transplantation following collection of stem cells using this mobilization regimen. OUTLINE: This is a multicenter study. Patients are stratified by disease (B-cell large cell lymphoma vs small non-cleaved cell lymphoma or B-cell acute lymphoblastic leukemia). Patients receive ifosfamide IV over 2 hours and etoposide IV over 1 hour on days 3-5, rituximab IV on days 1 and 3, and carboplatin IV over 1 hour on day 3. Patients receive filgrastim (G-CSF) subcutaneously once daily beginning on day 6 and continuing until blood counts recover. Patients also receive intrathecal (IT) chemotherapy comprising methotrexate and cytarabine. Patients with B-cell large cell lymphoma and negative CSF cytology receive IT chemotherapy on day 3 of the first course only. Patients with small non-cleaved cell lymphoma or B-cell acute lymphoblastic leukemia and negative CSF cytology receive IT chemotherapy on day 3. All patients with positive CSF cytology receive IT chemotherapy on days 3, 10, and 17 of the first and second courses. Treatment repeats every 23 days for up to 3 courses in the absence of disease progression or unacceptable toxicity. Patients are followed for survival. PROJECTED ACCRUAL: A total of 42-82 patients (21-41 per disease stratum) will be accrued for this study within 2-4 years.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: /21 Years
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically confirmed B-cell non-Hodgkin's lymphoma OR acute lymphoblastic leukemia - CD20+ (confirmed by flow cytometry of tumor tissue, involved marrow, or CD20 immunostaining) - The following histologies are generally CD20+ and are eligible: - Diffuse large B-cell lymphoma, mediastinal (thymic) large B-cell lymphoma, or follicular lymphoma, grade III (rare), documented by flow cytometry or appropriate immunohistochemistry, any stage - Burkitt's lymphoma or atypical Burkitt's/Burkitt-like lymphoma, any stage - B-cell acute lymphoblastic leukemia, with FABL3 morphology and/or demonstration of surface immunoglobin by flow cytometry - Atypical precursor B-cell lymphoblastic lymphoma or other unusual histologies that are CD20+ - Measurable disease by clinical, radiographic, or histologic criteria - Must be in first or later recurrence or have disease that is primarily refractory to conventional therapy - No isolated CNS disease PATIENT CHARACTERISTICS: Age - 21 or under when diagnosed with recurrent or refractory disease Performance status - ECOG 0-2 Life expectancy - At least 2 months Hematopoietic - Absolute neutrophil count at least 1,000/mm^3* - Platelet count at least 100,000/mm^3 (transfusion independent)* - Hemoglobin at least 10.0 g/dL (RBC transfusion allowed)* NOTE: *Patients with B-cell acute lymphoblastic leukemia and lymphoma involving bone marrow who have granulocytopenia, anemia, and/or thrombocytopenia are eligible but are not evaluable for hematologic toxicity Hepatic - Bilirubin no greater than 1.5 times normal - ALT less than 2.5 times normal Renal - No chronic renal insufficiency - No renal insufficiency secondary to tumor lysis syndrome Other - Not pregnant or nursing - Negative pregnancy test - Fertile patients must use effective contraception during and for 3 months after study treatment - No active uncontrolled infection - Seizure disorder allowed if well controlled with anticonvulsants - No CNS toxicity greater than grade II PRIOR CONCURRENT THERAPY: Biologic therapy - At least 1 week since prior growth factor(s) - At least 60 days since prior biologic (antineoplastic) therapy - Prior stem cell transplantation allowed provided the following criteria are met: - More than 60 days since transplantation - Hematopoietic lab value requirements are met (See Hematopoietic) - No evidence of graft-versus-host disease (if post-allogeneic transplantation) - Prior monoclonal antibody therapy allowed (including rituximab) - No other concurrent immunomodulating agents Chemotherapy - More than 2 weeks since prior myelosuppressive chemotherapy (4 weeks for nitrosoureas) - No other concurrent chemotherapy Endocrine therapy - No concurrent steroids (except for rituximab infusion-related symptoms) Radiotherapy - At least 2 weeks since prior local palliative radiotherapy (small port) - At least 6 weeks since prior substantial bone marrow radiotherapy - At least 6 months since prior craniospinal radiotherapy or radiotherapy to 50% or more of the pelvis - Concurrent radiotherapy to localized painful, airway-compromising, or other acute organ-threatening lesions allowed, provided at least 1 measurable lesion is not irradiated Surgery - Not specified Other - Recovered from prior therapy - No concurrent participation in another phase II study
Total Enrollment:
Location and Contact Information:
Overall Study Official:
TimothyGriffin, Study Chair, Cook Children's Medical Center - Fort Worth
Alfred I. duPont Hospital for Children *Recruiting*
Wilmington, Delaware, 19899
United States
Recruiting Rita Meek 302-651-5500
Phoenix Children's Hospital *Recruiting*
Phoenix, Arizona, 85016-7710
United States
Recruiting Paul Baranko 602-546-0920
Broward General Medical Center *Recruiting*
Ft. Lauderdale, Florida, 33316
United States
Recruiting Rudolph Roskos 954-355-4527
Joe DiMaggio Children's Hospital at Memorial *Recruiting*
Hollywood, Florida, 33021
United States
Recruiting Iftikhar Hanif 954-986-2234
UCSF Comprehensive Cancer Center *Recruiting*
San Francisco, California, 94115
United States
Recruiting Katherine Matthay 415-353-9510
Hurley Medical Center *Recruiting*
Flint, Michigan, 48503
United States
Recruiting Susumu Inoue 810-762-7303
St. John Hospital and Medical Center *Recruiting*
Detroit, Michigan, 48236
United States
Recruiting Hadi Sawaf 313-343-3964
Sunrise Hospital and Medical Center *Recruiting*
Las Vegas, Nevada, 89109
United States
Recruiting Jonathan Bernstein 702-732-0971
University of Texas Medical Branch *Recruiting*
Galveston, Texas, 77555-0361
United States
Recruiting Kwesi Sackey 409-772-2341
David Grant Medical Center *Recruiting*
Travis Air Force Base, California, 94535
United States
Recruiting Peter Chenaille 707-423-7176
All Children's Hospital *Recruiting*
St. Petersburg, Florida, 33701
United States
Recruiting Jerry Barbosa 727-892-4176
Presbyterian-St Luke's Medical Center *Recruiting*
Denver, Colorado, 80218
United States
Recruiting Stephen Palmer 719-471-2462
Royal Children's Hospital *Recruiting*
Brisbane, Queensland, 4029
Australia
Recruiting Liane Lockwood 617-363-61356
Academisch Ziekenhuis Groningen *Recruiting*
Groningen, , 9700 RB
Netherlands
Recruiting Willem Kamps 31-50-361-4213
Children's Hospital of Orange County *Recruiting*
Orange, California, 92868
United States
Recruiting Wei-Ping Shen 714-532-8636
Shands Cancer Center at the University of Florida Health Science Center *Recruiting*
Gainesville, Florida, 32610-0296
United States
Recruiting Stephen Hunger 352-392-5633
University of South Alabama Medical Center *Recruiting*
Mobile, Alabama, 36604
United States
Recruiting Yih-Ming Yang 251-405-5115
Southern Illinois University School of Medicine *Recruiting*
Springfield, Illinois, 62794-9658
United States
Recruiting Gregory Brandt 217-545-5817
Kosair Children's Hospital *Recruiting*
Louisville, Kentucky, 40202-3830
United States
Recruiting Salvatore Bertolone 502-852-8450
Cook Children's Medical Center - Fort Worth *Recruiting*
Ft. Worth, Texas, 76104
United States
Recruiting Timothy Griffin 682-885-4020
Cabell Huntington Hospital *Recruiting*
Huntington, West Virginia, 25701
United States
Recruiting Andrew Pendleton 304-691-1384
Hopital Sainte Justine *Recruiting*
Montreal, Quebec, H3T 1C5
Canada
Recruiting Albert Moghrabi 514-345-4969
Children's Hospital of Pittsburgh *Recruiting*
Pittsburgh, Pennsylvania, 15213
United States
Recruiting Arthur Ritchey 412-692-5949
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute *Recruiting*
Boston, Massachusetts, 02115
United States
Recruiting Holcombe Grier 617-632-3971
James P. Wilmot Cancer Center at University of Rochester Medical Center *Recruiting*
Rochester, New York, 14642
United States
Recruiting Barbara Asselin 716-275-2981
St. Mary's Hospital *Recruiting*
West Palm Beach, Florida, 33407
United States
Recruiting Narayana Gowda 561-840-6125
Mountain States Tumor Institute - Boise *Recruiting*
Boise, Idaho, 83712
United States
Recruiting J. Johnston 208-381-2782
UNMC Eppley Cancer Center at the University of Nebraska Medical Center *Recruiting*
Omaha, Nebraska, 68198-2168
United States
Recruiting Peter Coccia 402-559-7257
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins *Recruiting*
Baltimore, Maryland, 21231-2410
United States
Recruiting Cindy Schwartz 410-955-2457
St. Christopher's Hospital for Children *Recruiting*
Philadelphia, Pennsylvania, 19134-1095
United States
Recruiting Gregory Halligan 215-427-5000
Deaconess Medical Center *Recruiting*
Spokane, Washington, 99210-0248
United States
Recruiting Steven Bergstrom 509-473-7012
Cardinal Glennon Children's Hospital *Recruiting*
St. Louis, Missouri, 63104
United States
Recruiting Dennis O'Connor 314-577-5638
St. Vincent Mercy Medical Center *Recruiting*
Toledo, Ohio, 43608
United States
Recruiting Rama Jasty 419-251-8215
John Stoddard Cancer Center at Iowa Methodist Medical Center *Recruiting*
Des Moines, Iowa, 50309
United States
Recruiting Stephen Elliott 515-241-4245
Sutter Cancer Center *Recruiting*
Sacramento, California, 95816
United States
Recruiting Yisheng Lee 916-454-6700
Children's Hospital Central California *Recruiting*
Madera, California, 93638-8762
United States
Recruiting Vonda Crouse 559-353-5480
Sinai Hospital of Baltimore *Recruiting*
Baltimore, Maryland, 21225
United States
Recruiting Joseph Wiley 410-601-5864
Nemours Children's Clinic *Recruiting*
Jacksonville, Florida, 32207
United States
Recruiting Eric Sandler 904-390-3793
Dakota Cancer Institute at Innovis Health - Dakota Clinic *Recruiting*
Fargo, North Dakota, 58103-4940
United States
Recruiting Janet Tillisch 701-364-4966
Children's Hospital of Columbus *Recruiting*
Columbus, Ohio, 43205-2696
United States
Recruiting Amanda Termuhlen 614-722-3552
East Tennessee State University Cancer Center at Johnson City Medical Center *Recruiting*
Johnson City, Tennessee, 37604
United States
Recruiting Sharon Castellino 423-433-6200
Texas Tech University Health Sciences Center School of Medicine *Recruiting*
Amarillo, Texas, 79106
United States
Recruiting Curtis Turner 806-354-5434
Children's Hospital of Philadelphia *Recruiting*
Philadelphia, Pennsylvania, 19104
United States
Recruiting Beverly Lange 215-590-2249
Jonathan Jaques Children's Cancer Center at Miller Children's Hospital *Recruiting*
Long Beach, California, 90801-1428
United States
Recruiting William Roberts 562-933-8600
Children's Hospitals and Clinics - Minnesota *Recruiting*
St. Paul, Minnesota, 55102
United States
Recruiting Christopher Moertel 651-220-6732
University of Chicago Cancer Research Center *Recruiting*
Chicago, Illinois, 60601
United States
Recruiting James Nachman 773-702-6808
Children's Hospital at Westmead *Recruiting*
Westmead, New South Wales, 2145
Australia
Recruiting Geoffrey McCowage 61-2-9845-2122
William Beaumont Hospital - Royal Oak *Recruiting*
Royal Oak, Michigan, 48073-6769
United States
Recruiting Charles Main 248-551-0360
Rush-Presbyterian-St. Luke's Medical Center *Recruiting*
Chicago, Illinois, 60612
United States
Recruiting Allen Korenblit 312-942-5983
University of California Davis Cancer Center *Recruiting*
Sacramento, California, 95817
United States
Recruiting Theodore Zwerdling 916-734-2781
St. Jude Children's Research Hospital *Recruiting*
Memphis, Tennessee, 38105-2794
United States
Recruiting Wayne Furman 901-495-3300
Children's Hospital of New Orleans *Recruiting*
New Orleans, Louisiana, 70118
United States
Recruiting Rajasekharan Warrier 504-568-4561
Geisinger Medical Center *Recruiting*
Danville, Pennsylvania, 17822-1320
United States
Recruiting Jeffrey Taylor 570-271-6848
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill *Recruiting*
Chapel Hill, North Carolina, 27599-7295
United States
Recruiting Stuart Gold 919-966-0985
Tampa Children's Hospital *Recruiting*
Tampa, Florida, 33677-4227
United States
Recruiting Cameron Tebbi 813-870-4252
University of Puerto Rico School of Medicine Medical Sciences Campus *Recruiting*
San Juan, , 00936-5067
Puerto Rico
Recruiting Nilka Barrios 787-756-3230
University of Mississippi Medical Center *Recruiting*
Jackson, Mississippi, 39216-4505
United States
Recruiting Dale Pullen 601-984-5220
University of Wisconsin Comprehensive Cancer Center *Recruiting*
Madison, Wisconsin, 53792-6164
United States
Recruiting Diane Puccetti 608-263-0320
Mount Sinai School of Medicine *Recruiting*
New York City, New York, 10029
United States
Recruiting Elizabeth Raetz 212-241-7022
Duke Comprehensive Cancer Center *Recruiting*
Durham, North Carolina, 27710
United States
Recruiting Philip Breitfeld 919-684-3377
University of Arkansas for Medical Sciences *Recruiting*
Little Rock, Arkansas, 72205
United States
Recruiting David Becton 501-320-5650
Lombardi Cancer Center at Georgetown University Medical Center *Recruiting*
Washington D.C., District of Columbia, 20007
United States
Recruiting Aziza Shad 202-687-2224
Jackson Memorial Hospital *Recruiting*
Miami, Florida, 33136
United States
Recruiting Stuart Toledano 305-585-5635
San Antonio Military Pediatric Cancer and Blood Disorders Center *Recruiting*
Lackland Air Force Base, Texas, 78236
United States
Recruiting Aaron Pitney 210-292-5684
Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center *Recruiting*
Los Angeles, California, 90048
United States
Recruiting Moshe Arditi 310-423-4471
University of Connecticut Cancer Center at University of Connecticut Health Center *Recruiting*
Farmington, Connecticut, 06360-7106
United States
Recruiting Arnold Altman 860-545-9630
Sydney Children's Hospital *Recruiting*
Randwick, New South Wales, 2031
Australia
Recruiting Glenn Marshall 61-2-9382-1721
Kaiser Permanente Medical Center - San Francisco Geary Campus *Recruiting*
San Francisco, California, 94115
United States
Recruiting Kenneth Leung 415-833-3528
St. Vincent Hospital and Health Care Center *Recruiting*
Indianapolis, Indiana, 46260
United States
Recruiting Randy Hock 317-338-4673
East Tennessee Children's Hospital *Recruiting*
Knoxville, Tennessee, 37901
United States
Recruiting Ray Pais 865-541-8266
Lucile Packard Children's Hospital at Stanford University Medical Center *Recruiting*
Palo Alto, California, 94304
United States
Recruiting Neyssa Marina 650-723-5535
Covenant Children's Hospital *Recruiting*
Lubbock, Texas, 79410
United States
Recruiting John Iacuone 806-725-1011
Children's Hospital of Michigan *Recruiting*
Detroit, Michigan, 48201
United States
Recruiting Yaddanapudi Ravindranath 313-745-5649
Children's Hospitals and Clinics - Minneapolis *Recruiting*
Minneapolis, Minnesota, 55404
United States
Recruiting Maura O'Leary 612-813-5940
Presbyterian Healthcare *Recruiting*
Charlotte, North Carolina, 28233
United States
Recruiting Mark Mogul 704-384-1900
Midwest Children's Cancer Center *Recruiting*
Milwaukee, Wisconsin, 53226
United States
Recruiting Bruce Camitta 414-456-4118
Mission St. Joseph's Health System *Recruiting*
Asheville, North Carolina, 28801
United States
Recruiting Orren Beaty 823-213-5770
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center *Recruiting*
Savannah, Georgia, 31405
United States
Recruiting Tribhawan Vats 912-350-8194
Raymond Blank Memorial Hospital for Children *Recruiting*
Des Moines, Iowa, 50308
United States
Recruiting Torrey Mitchell 515-241-8912
Baylor College of Medicine *Recruiting*
Houston, Texas, 77030
United States
Recruiting C. Steuber 713-770-4200
Floating Hospital for Children *Recruiting*
Boston, Massachusetts, 02111
United States
Recruiting Cynthia Kretschmar 617-636-5535
Herbert Irving Comprehensive Cancer Center at Columbia University *Recruiting*
New York City, New York, 10032
United States
Recruiting Linda Granowetter 212-305-8652
MBCCOP - LSU Health Sciences Center *Recruiting*
New Orleans, Louisiana, 70112
United States
Recruiting Jill Gilbert 504-568-5136
New York Weill Cornell Cancer Center at Cornell University *Recruiting*
New York City, New York, 10021
United States
Recruiting Patricia Giardina 212-746-3400
Cancer Center at the University of Virginia *Recruiting*
Charlottesville, Virginia, 22908
United States
Recruiting Pedro de Alarcon 434-924-5105
Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina *Recruiting*
Greenville, North Carolina, 27858-4354
United States
Recruiting Sarah Strandjord 252-744-4676
CCOP - Scott and White Hospital *Recruiting*
Temple, Texas, 76508
United States
Recruiting Lucas Wong 254-724-7048
Lutheran General Cancer Care Center *Recruiting*
Park Ridge, Illinois, 60068-1174
United States
Recruiting Jong-Hyo Kwon 847-723-5962
McGill University Health Center - Montreal Children's Hospital *Recruiting*
Montreal, Quebec, H3G 1A4
Canada
Recruiting Carolyn Freeman 514-412-8040
Blumenthal Cancer Center at Carolinas Medical Center *Recruiting*
Charlotte, North Carolina, 28232-2861
United States
Recruiting Daniel McMahon 704-355-1130
West Virginia University Hospitals *Recruiting*
Morgantown, West Virginia, 26506-9300
United States
Recruiting Frank Keller 304-293-1217
Carilion Medical Center for Children *Recruiting*
Roanoke, Virginia, 24029
United States
Recruiting Joan Fisher 540-985-8055
Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center *Recruiting*
Nashville, Tennessee, 37232-6838
United States
Recruiting James Whitlock 615-936-1762
Group Health Central Hospital *Recruiting*
Seattle, Washington, 98112
United States
Recruiting Philip Herzog 425-883-5291
Southern California Permanente Medical Group *Recruiting*
Downey, California, 90242
United States
Recruiting Willye Powell 562-803-2472
Yale Comprehensive Cancer Center *Recruiting*
New Haven, Connecticut, 06520-8028
United States
Recruiting Jack Hoff 203-785-4095
Baptist Hospital of Miami *Recruiting*
Miami, Florida, 33176-2197
United States
Recruiting Doured Daghistani 786-596-1960
Cancer Institute of New Jersey *Recruiting*
New Brunswick, New Jersey, 08903
United States
Recruiting Richard Drachtman 732-235-7898
Santa Barbara Cottage Hospital *Recruiting*
Santa Barbara, California, 93102
United States
Recruiting Felicity Hodder 805-569-8394
University of New Mexico Cancer Research and Treatment Center *Recruiting*
Albuquerque, New Mexico, 87131
United States
Recruiting Jami Frost 505-272-4461
Norris Cotton Cancer Center at Dartmouth Medical School *Recruiting*
Lebanon, New Hampshire, 03756
United States
Recruiting Eric Larsen 603-650-5541
Florida Hospital Cancer Institute *Recruiting*
Orlando, Florida, 32804
United States
Recruiting Jane Crofton 407-303-2090
Cleveland Clinic Taussig Cancer Center *Recruiting*
Cleveland, Ohio, 44195
United States
Recruiting Karen Bringelsen 216-444-7923
Marlene and Stewart Greenebaum Cancer Center, University of Maryland *Recruiting*
Baltimore, Maryland, 21201-1595
United States
Recruiting Neil Grossman 410-328-2808
Valerie Fund Children's Center at Atlantic Health *Recruiting*
Summit, New Jersey, 07901
United States
Recruiting Hazem Mahmoud 973-971-6731
West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division *Recruiting*
Charleston, West Virginia, 25302
United States
Recruiting Sanjeev Grover 304-388-1540
CCOP - Marshfield Clinic Research Foundation *Recruiting*
Marshfield, Wisconsin, 54449
United States
Recruiting Tarit Banerjee 715-387-5134
Baystate Medical Center *Recruiting*
Springfield, Massachusetts, 01107
United States
Recruiting David Steele 413-794-9338
North Shore University Hospital *Recruiting*
Manhasset, New York, 11030
United States
Recruiting Indira Sahdev 718-470-3460
Brookdale University Hospital and Medical Center *Recruiting*
Brooklyn, New York, 11212
United States
Recruiting Kusum Viswanathan 718-240-5904
Schneider Children's Hospital *Recruiting*
New Hyde Park, New York, 11042
United States
Recruiting Arlene Redner 718-470-3460
Kaiser Permanente Medical Center - Santa Clara *Recruiting*
Santa Clara, California, 95051-5386
United States
Recruiting Carolyn Russo 408-236-5028
CCOP - St. Vincent Hospital Cancer Center, Green Bay *Recruiting*
Green Bay, Wisconsin, 54301
United States
Recruiting Thomas Saphner 920-432-5134
University of Alabama at Birmingham Comprehensive Cancer Center *Recruiting*
Birmingham, Alabama, 35233
United States
Recruiting Robert Castleberry 205-939-9285
Legacy Emanuel Hospital and Health Center & Children's Hospital *Recruiting*
Portland, Oregon, 97227
United States
Recruiting Janice Olson 503-413-2200
Children's National Medical Center *Recruiting*
Washington D.C., District of Columbia, 20010-2970
United States
Recruiting Nita Seibel 202-884-2144
Rhode Island Hospital *Recruiting*
Providence, Rhode Island, 02818
United States
Recruiting William Ferguson 401-444-5171
Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas *Recruiting*
Dallas, Texas, 75390-9063
United States
Recruiting Naomi Winick 214-648-3074
Saint Jude Midwest Affiliate *Recruiting*
Peoria, Illinois, 61637
United States
Recruiting John McCallister 309-624-4945
Center for Cancer Prevention and Care at Scott and White Clinic *Recruiting*
Temple, Texas, 76508
United States
Recruiting Lawrence Frankel 254-724-2006
Palmetto Health South Carolina Cancer Center *Recruiting*
Columbia, South Carolina, 29203
United States
Recruiting Ronnie Neuberg 803-434-3533
Huntsman Cancer Institute *Recruiting*
Salt Lake City, Utah, 84112
United States
Recruiting Carol Bruggers 801-585-0303
Maimonides Medical Center *Recruiting*
Brooklyn, New York, 11219
United States
Recruiting Ludovico Guarini 718-283-8173
Children's Medical Center - Dayton *Recruiting*
Dayton, Ohio, 45404
United States
Recruiting Emmett Broxson 937-641-3111
Advocate Hope Children's Hospital *Recruiting*
Oak Lawn, Illinois, 60453
United States
Recruiting Sharad Salvi 708-346-4094
Massey Cancer Center at Virginia Commonwealth University *Recruiting*
Richmond, Virginia, 23298-0037
United States
Recruiting Edward Russell 804-828-0450
Arizona Cancer Center at University of Arizona Health Sciences Center *Recruiting*
Tucson, Arizona, 85724
United States
Recruiting Michael Graham 520-626-6044
Childhood Hematology/Oncology Associates *Recruiting*
Denver, Colorado, 80218
United States
Recruiting Edward Arenson 303-832-2462
Spectrum Health and DeVos Children's Hospital *Recruiting*
Grand Rapids, Michigan, 49503
United States
Recruiting David Freyer 616-391-2086
St. Louis Children's Hospital *Recruiting*
St. Louis, Missouri, 63110
United States
Recruiting Lori Luchtman-Jones 314-454-6000
Saskatoon Cancer Centre *Recruiting*
Saskatoon, Saskatchewan, S7N 4H4
Canada
Recruiting Ali Kaiser 306-655-2684
Brooklyn Hospital Center *Recruiting*
Brooklyn, New York, 11201-5493
United States
Recruiting Swayamprabha Sadanandan 718-250-6074
Long Island Cancer Center at Stony Brook University Hospital *Recruiting*
Stony Brook, New York, 11794
United States
Recruiting Robert Parker 631-689-6000
Toledo Children's Hospital *Recruiting*
Toledo, Ohio, 43601
United States
Recruiting Richard Shore 419-471-5437
Children's Hospital of Greenville Hospital System *Recruiting*
Greenville, South Carolina, 29605
United States
Recruiting Cary Stroud 864-455-8898
Children's Hospital Los Angeles *Recruiting*
Los Angeles, California, 90027-0700
United States
Recruiting Paul Gaynon 323-669-2163
Loma Linda University Cancer Institute at Loma Linda University Medical Center *Recruiting*
Loma Linda, California, 92354
United States
Recruiting Antranik Bedros 909-558-3391
Newark Beth Israel Medical Center *Recruiting*
Newark, New Jersey, 07112-2094
United States
Recruiting Peri Kamalakar 973-926-7161
Forum Health-Tod Childrens Hospital *Recruiting*
Youngstown, Ohio, 44501
United States
Recruiting Ayman Saleh 330-884-3955
University of Massachusetts Memorial Medical Center - University Campus *Recruiting*
Worcester, Massachusetts, 01655
United States
Recruiting Ghazala Usmani 508-856-4225
Children's Hospital of Austin *Recruiting*
Austin, Texas, 78701
United States
Recruiting Sharon Lockhart 512-324-8480
Children's Hospital of Southwest Florida *Recruiting*
Ft. Myers, Florida, 33908
United States
Recruiting Emad Salman 941-432-3333
University of Missouri - Columbia *Recruiting*
Columbia, Missouri, 65203
United States
Recruiting Katherine Kelly 573-882-3933
Medical Center of Central Georgia *Recruiting*
Macon, Georgia, 31201
United States
Recruiting Hassan Dannawi 478-633-1104
Avera Cancer Institute *Recruiting*
Sioux Falls, South Dakota, 57105-1080
United States
Recruiting Marwan Hanna 605-322-7595
Children's Hospital Medical Center of Akron *Recruiting*
Akron, Ohio, 44308
United States
Recruiting Jeffrey Hord 330-543-8580
Penn State Cancer Institute at Milton S. Hershey Medical Center *Recruiting*
Hershey, Pennsylvania, 17033-0850
United States
Recruiting John Neely 717-531-6012
University of Michigan Comprehensive Cancer Center *Recruiting*
Ann Arbor, Michigan, 48109-0914
United States
Recruiting Raymond Hutchinson 734-936-8785
Josephine Ford Cancer Center at Henry Ford Hospital *Recruiting*
Detroit, Michigan, 48202
United States
Recruiting Hassan Yaish 313-916-3138
Wesley Medical Center *Recruiting*
Wichita, Kansas, 67214
United States
Recruiting David Rosen 316-962-2025
St. Mary's - Duluth Clinic Cancer Center *Recruiting*
Duluth, Minnesota, 55805
United States
Recruiting Jacquelyn Wiermaa 218-786-3625
University of Texas Health Science Center at San Antonio *Recruiting*
San Antonio, Texas, 78207
United States
Recruiting Paul Thomas 210-704-3405
Swiss Pediatric Oncology Group Bern *Recruiting*
Bern, , CH 3010
Switzerland
Recruiting Annette Ridolfi-Luethy 41-31-632-9372
Nemours Children's Clinic-Orlando *Recruiting*
Orlando, Florida, 32806
United States
Recruiting Vincent Giusti 407-650-7230
Tulane University School of Medicine *Recruiting*
New Orleans, Louisiana, 70112
United States
Recruiting Marshall Schorin 504-588-5412
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus *Recruiting*
Atlanta, Georgia, 30342
United States
Recruiting Stephen Lauer 404-250-2781
Children's Hospital and Regional Medical Center - Seattle *Recruiting*
Seattle, Washington, 98105
United States
Recruiting Douglas Hawkins 206-987-3096
British Columbia Children's Hospital *Recruiting*
Vancouver, British Columbia, V6H 3V4
Canada
Recruiting Paul Rogers 604-875-2322
Centre de Recherche du Centre Hospitalier de l'Universite Laval *Recruiting*
Sainte-Foy, Quebec, GIV 4G2
Canada
Recruiting Yvan Samson 418-656-4141
University Hospital at State University of New York - Upstate Medical University *Recruiting*
Syracuse, New York, 13210
United States
Recruiting Ronald Dubowy 315-464-5294
Mayo Clinic Cancer Center *Recruiting*
Rochester, Minnesota, 55905
United States
Recruiting Carola Arndt 507-284-4822
Alberta Children's Hospital *Recruiting*
Calgary, Alberta, T2T 5C7
Canada
Recruiting Douglas Strother 403-943-7272
Miami Children's Hospital *Recruiting*
Miami, Florida, 33155-4069
United States
Recruiting Enrique Escalon 305-662-8360
Holden Comprehensive Cancer Center at University of Iowa *Recruiting*
Iowa City, Iowa, 52242-1009
United States
Recruiting Raymond Tannous 319-356-1905
CCOP - Columbia River Oncology Program *Recruiting*
Portland, Oregon, 97225
United States
Recruiting Keith Lanier 503-216-6260
Hollings Cancer Center at Medical University of South Carolina *Recruiting*
Charleston, South Carolina, 29425-0721
United States
Recruiting Julio Barredo 803-792-2957
Ireland Cancer Center *Recruiting*
Cleveland, Ohio, 44106-5065
United States
Recruiting Eric Kodish 216-844-5432
Comprehensive Cancer Center at Wake Forest University *Recruiting*
Winston Salem, North Carolina, 27157-1081
United States
Recruiting Thomas McLean 336-716-4324
Naval Medical Center, Portsmouth *Recruiting*
Portsmouth, Virginia, 23708-5100
United States
Recruiting Paulette Bryant 804-398-5767
Eastern Maine Medical Center *Recruiting*
Bangor, Maine, 04401
United States
Recruiting Judith Allen 207-973-7520
Bronson Methodist Hospital *Recruiting*
Kalamazoo, Michigan, 49007
United States
Recruiting Leonard Mattano 269-341-6350
Inova Fairfax Hospital *Recruiting*
Falls Church, Virginia, 22042-3300
United States
Recruiting Jay Greenberg 703-698-1110
Cross Cancer Institute *Recruiting*
Edmonton, Alberta, T6G 1Z2
Canada
Recruiting Paul Grundy 780-432-8894
Children's Hospital of Western Ontario *Recruiting*
London, Ontario, N6C 2V5
Canada
Recruiting Anne Lois Cairney 519-685-8494
St. Joseph's Hospital and Medical Center *Recruiting*
Paterson, New Jersey, 07503
United States
Recruiting Mary Bonilla 973-754-3230
Children's Hospital at O.U. Medical Center *Recruiting*
Oklahoma City, Oklahoma, 73104
United States
Recruiting William Meyer 405-271-5437
San Jorge Childrens Hospital *Recruiting*
Santurce, , 00912
Puerto Rico
Recruiting Luis Clavell 787-728-1575
Cancer Center of Albany Medical Center *Recruiting*
Albany, New York, 12208
United States
Recruiting Jennifer Pearce 518-262-5513
Ochsner Clinic Foundation *Recruiting*
New Orleans, Louisiana, 70121
United States
Recruiting Marquis Hodes 504-842-5230
Children's Hospital of Denver *Recruiting*
Denver, Colorado, 80218-1088
United States
Recruiting Roger Giller 303-861-6892
Swiss Pediatric Oncology Group Lausanne *Recruiting*
Lausanne, , CH 1011
Switzerland
Recruiting Maja Popovic 41-21-314-3567
IWK Health Centre *Recruiting*
Halifax, Nova Scotia, B3J 3G9
Canada
Recruiting Dorothy Barnard 902-470-8291
State University of New York Health Science Center at Brooklyn College of Medicine *Recruiting*
Brooklyn, New York, 11203
United States
Recruiting Sreedhar Rao 718-270-1693
Doernbecher Children's Hospital at Oregon Health & Science University *Recruiting*
Portland, Oregon, 97239-3098
United States
Recruiting H. Nicholson 503-494-1543
Women's and Children's Hospital *Recruiting*
North Adelaide, South Australia, 5006
Australia
Recruiting Maria Kirby 61-8-8161-7411
Cancer Research Center of Hawaii *Recruiting*
Honolulu, Hawaii, 96813
United States
Recruiting Robert Wilkinson 808-586-2979
Princess Margaret Hospital for Children *Recruiting*
Perth, Western Australia, 6001
Australia
Recruiting David Baker 61-8-9340-8234
Markey Cancer Center at University of Kentucky Chandler Medical Center *Recruiting*
Lexington, Kentucky, 40536-0284
United States
Recruiting Martha Greenwood 859-323-6771
Maine Children's Cancer Program *Recruiting*
Scarborough, Maine, 04074-9308
United States
Recruiting Craig Hurwitz 207-885-7565
Tripler Army Medical Center *Recruiting*
Honolulu, Hawaii, 96859-5000
United States
Recruiting Braden Shoupe 808-433-6057
Memorial Sloan-Kettering Cancer Center *Recruiting*
New York City, New York, 10021
United States
Recruiting Peter Steinherz 212-639-7951
Children's Hospital of Omaha *Recruiting*
Omaha, Nebraska, 68114
United States
Recruiting Minnie Abromowitch 402-955-3950
Swiss Pediatric Oncology Group Geneva *Recruiting*
Geneva, , CH 1211
Switzerland
Recruiting Pierre Wacker 41-22-382-3311
Sioux Valley Hospital at University of South Dakota Medical Center *Recruiting*
Sioux Falls, South Dakota, 57117
United States
Recruiting Jakica Tancabelic 605-333-7171
Children's Hospital of the King's Daughters *Recruiting*
Norfolk, Virginia, 23507
United States
Recruiting Rebecca Byrd 757-668-7243
Rebecca and John Moores UCSD Cancer Center *Recruiting*
La Jolla, California, 92093-0658
United States
Recruiting Richard Kadota 858-657-7020
Janeway Children's Health and Rehabilitation Centre *Recruiting*
St. John's, Newfoundland and Labrador, A1B 3V6
Canada
Recruiting John Hand 709-777-4799
MBCCOP - Hawaii *Recruiting*
Honolulu, Hawaii, 96813
United States
Recruiting Brian Issell 808-586-3013
Children's Mercy Hospital *Recruiting*
Kansas City, Missouri, 64108
United States
Recruiting Maxine Hetherington 816-234-3265
Cancer Center at Hackensack University Medical Center *Recruiting*
Hackensack, New Jersey, 07601
United States
Recruiting Michael Harris 201-996-5437
Natalie Warren Bryant Cancer Center *Recruiting*
Tulsa, Oklahoma, 74136
United States
Recruiting Martina Hum 918-494-2525
Methodist Cancer Center at Methodist Specialty and Transplant Hospital *Recruiting*
San Antonio, Texas, 78229-3902
United States
Recruiting Jaime Estrada 210-575-8130
Sacred Heart Children's Hospital *Recruiting*
Pensacola, Florida, 32504
United States
Recruiting John Kelleher 850-505-4798
University of Texas - MD Anderson Cancer Center *Recruiting*
Houston, Texas, 77030-4009
United States
Recruiting Joann Ater 713-792-6665
Children's Memorial Hospital - Chicago *Recruiting*
Chicago, Illinois, 60614
United States
Recruiting Susan Cohn 773-880-4562
Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center *Recruiting*
Orange, California, 92868
United States
Recruiting Stanley Calderwood 714-456-6615
Breslin Cancer Center at Ingham Regional Medical Center *Recruiting*
Lansing, Michigan, 48910
United States
Recruiting Renuka Gera 517-334-2337
Marshfield Clinic *Recruiting*
Marshfield, Wisconsin, 54449-5772
United States
Recruiting H. Nickerson 715-387-5018
Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego *Recruiting*
San Diego, California, 92120
United States
Recruiting Wellington Loh 619-516-6144
New York Medical College *Recruiting*
Valhalla, New York, 10595
United States
Recruiting M. Ozkaynak 914-493-7997
Fred Hutchinson Cancer Research Center *Recruiting*
Seattle, Washington, 98109-1024
United States
Recruiting Jean Sanders 206-667-4348
Starship Children's Hospital *Recruiting*
Auckland, ,
New Zealand
Recruiting Lochie Teague 64-9-307-4949 ext. 6295
Cincinnati Children's Hospital Medical Center *Recruiting*
Cincinnati, Ohio, 45229-3039
United States
Recruiting John Perentesis 513-636-6090
CCOP - Oklahoma *Recruiting*
Tulsa, Oklahoma, 74136
United States
Recruiting James Lockhart 918-491-5878
Mary Bridge Children's Health Center *Recruiting*
Tacoma, Washington, 98415-0299
United States
Recruiting William Thomas 253-403-4915
St. Vincent Hospital *Recruiting*
Green Bay, Wisconsin, 54307-9070
United States
Recruiting Jon Brandt 920-433-8670
Albert Einstein Clinical Cancer Center *Recruiting*
Bronx, New York, 10461
United States
Recruiting Eva Radel 718-920-7844
Hospital for Sick Children *Recruiting*
Toronto, Ontario, M5G 1X8
Canada
Recruiting Sheila Weitzman 416-813-5872
Children's Hospital and Health Center, San Diego *Recruiting*
San Diego, California, 92123-4282
United States
Recruiting Richard Kadota 858-966-5811
Jonsson Comprehensive Cancer Center, UCLA *Recruiting*
Los Angeles, California, 90095-1781
United States
Recruiting Stephen Feig 310-825-5268
Vermont Cancer Center at University of Vermont *Recruiting*
Burlington, Vermont, 05401-3498
United States
Recruiting Alan Homans 802-847-2850
Bellin Memorial Hospital *Recruiting*
Green Bay, Wisconsin, 54301
United States
Recruiting Dorothy Ganick 920-433-6025
Madigan Army Medical Center *Recruiting*
Tacoma, Washington, 98431-5000
United States
Recruiting Kelly Faucette 253-968-1864
Medical College of Georgia Comprehensive Cancer Center *Recruiting*
Augusta, Georgia, 30912-4000
United States
Recruiting Hernan Sabio 706-721-3626
Walter Reed Army Medical Center *Recruiting*
Washington D.C., District of Columbia, 20307-5000
United States
Recruiting E. Edwards 202-782-9449
CCOP - Beaumont *Recruiting*
Royal Oak, Michigan, 48073-6769
United States
Recruiting David Decker 248-551-7695
CancerCare Manitoba *Recruiting*
Winnipeg, Manitoba, R3E 0V9
Canada
Recruiting Rochelle Yanofsky 204-787-4163
McMaster Children's Hospital at Hamilton Health Sciences *Recruiting*
Hamilton, Ontario, L8N 3Z5
Canada
Recruiting Ronald Barr 905-521-2100 ext. 73464
Children's Hospital and Research Center at Oakland *Recruiting*
Oakland, California, 94609-1809
United States
Recruiting James Feusner 510-428-3000
Children's Hospital of Eastern Ontario *Recruiting*
Ottawa, Ontario, K1H 8L1
Canada
Recruiting Jacqueline Halton 613-737-7600 ext. 2370
Allan Blair Cancer Centre *Recruiting*
Regina, Saskatchewan, S4T 7T1
Canada
Recruiting Christina Suan Goh 306-766-2205
Medical City Dallas Hospital *Recruiting*
Dallas, Texas, 75230
United States
Recruiting Carl Lenarsky 214-788-6647
University of Illinois Medical Center *Recruiting*
Chicago, Illinois, 60612
United States
Recruiting Mary Schmidt 312-996-6143
Indiana University Cancer Center *Recruiting*
Indianapolis, Indiana, 46202-5289
United States
Recruiting Robert Fallon 317-274-8784
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center *Recruiting*
La Crosse, Wisconsin, 54601
United States
Recruiting Robert Ettinger 608-782-7300
Royal Children's Hospital *Recruiting*
Parkville, Victoria, 3052
Australia
Recruiting David Ashley 61-39-345-5522
Additional Information:
Study ID Numbers: CDR0000298751; COG-ANHL0121
Study Start Date:
Record last reviewed: November 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00058461
Other Recurrent Childhood Large Cell Lymphoma Studies:
1. Monoclonal Antibody Therapy in Treating Patients With Lymphoproliferative Disorder Associated With Immunosuppression Therapy
2. Peripheral Stem Cell Transplantation Following Radiation Therapy in Treating Patients With Hodgkin's Disease or Non-Hodgkin's Lymphoma
3. Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Recurrent or Refractory Hodgkin's or Non-Hodgkin's Lymphoma
4. Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia
5. Chemotherapy in Treating Young Patients With Recurrent or Refractory Meningeal Leukemia, Lymphoma, or Solid Tumors
Related Studies:
Other recurrent childhood large cell lymphoma Clinical Trials
Other New Jersey Clinical Trials
Other New Brunswick Clinical Trials
Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia
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