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Combination Chemotherapy and Radiation Therapy in Treating Patients With Stage IIIB Non-Small Cell Lung Cancer Clinical Trials Facts presented on Clinical Trials Search isn't designed to be a substitute for proven healthcare advice, calls or treatment by using a genuine medical doctor. We aren't mDs. Always confer with your doctor on Combination Chemotherapy and Radiation Therapy in Treating Patients With Stage IIIB Non-Small Cell Lung Cancer conditions. Clinical Trials Search.org is a website devoted to listing clinical research studies in human subjects. Combination Chemotherapy and Radiation Therapy in Treating Patients With Stage IIIB Non-Small Cell Lung Cancer Clinical research trials and Combination Chemotherapy and Radiation Therapy in Treating Patients With Stage IIIB Non-Small Cell Lung Cancer healthcare trials occur in a lot of of places across the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectivity of new does drugs. The role of the studies / undertakings is to solve specific human healthcare questions. Clinical trials are a popular way for doctors, government agencies, and private sector companies to find treatments for all kinds of conditions, including Combination Chemotherapy and Radiation Therapy in Treating Patients With Stage IIIB Non-Small Cell Lung Cancer. Combination Chemotherapy and Radiation Therapy in Treating Patients With Stage IIIB Non-Small Cell Lung Cancer Clinical Trials and other clinical trials allow for volunteers to access health treatment choices before they are available to the general public. Many times the test subjects get treatment for without cost, and sometimes they are compensated for their time. Occasionally there is a cost for a Combination Chemotherapy and Radiation Therapy in Treating Patients With Stage IIIB Non-Small Cell Lung Cancer clinical trial. Test subjects typically receive the most effective healthcare possible for their Combination Chemotherapy and Radiation Therapy in Treating Patients With Stage IIIB Non-Small Cell Lung Cancer condition. Risks are a reality, nonetheless, and could include extra or frequent dr. calls, health hazards (perhaps life-jeopardizing), and/or the treatment being ineffective. Trials are federally regulated with rigid guidelines to protect clinical trials subjects.
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Home > "C" Clinical Trials Conditions > Combination Chemotherapy and Radiation Therapy in Treating Patients With Stage IIIB Non-Small Cell Lung Cancer  Combination Chemotherapy and Radiation Therapy in Treating Patients With Stage IIIB Non-Small Cell Lung Cancer
Combination Chemotherapy and Radiation Therapy in Treating Patients With Stage IIIB Non-Small Cell Lung Cancer
For Condition: large cell lung cancer,stage 3B non-small cell lung cancer,squamous cell lung cancer,adenocarcinoma of the lung
Status: No longer recruiting
Sponsor(s): Southwest Oncology Group , National Cancer Institute (NCI)
Synopsis: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy plus radiation therapy in treating patients who have stage IIIB non-small cell lung cancer.
Details: OBJECTIVES: - Determine survival and time to treatment failure in patients with stage IIIB non-small cell lung cancer treated with induction docetaxel, cisplatin, and radiotherapy followed by consolidation docetaxel. - Determine the response rate in these patients when treated with this regimen. - Determine the toxic effects of this regimen in these patients. OUTLINE: This is a multicenter study. Patients receive induction chemotherapy comprising docetaxel IV over 30 minutes on days 1, 8, 15, 22, 29, and 36 and cisplatin IV over 60 minutes on days 1, 8, 29, and 36. Patients also undergo concurrent radiotherapy daily, 5 days per week, for 6.5 weeks. At least 1 week and no more than 4 weeks after completion of induction chemoradiotherapy, patients with stable or responding disease receive docetaxel IV over 60 minutes on day 1. Treatment repeats every 21 days for 3 courses in the absence of disease progression or unacceptable toxicity. Patients are followed every 2 months for 1 year, every 3 months for 1 year, and then every 6 months for 1 year. PROJECTED ACCRUAL: A total of 90 patients will be accrued for this study within 30 months.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically or cytologically confirmed stage IIIB non-small cell lung cancer - Adenocarcinoma - Large cell carcinoma - Squamous cell carcinoma - Pathologically or radiographically documented positive N3 nodes - No positive supraclavicular or scalene lymph nodes with disease extending into the cervical region OR - T4 tumor invading any of the following: - Mediastinum - Heart - Great vessels - Trachea - Esophagus - Vertebral body - Carina - No brain, contralateral chest, liver, or adrenal metastases - No more than 1 parenchymal lesion - No malignant pleural effusions unless they are only visible on CT scan or deemed too small to tap - No pericardial effusions - Measurable disease PATIENT CHARACTERISTICS: Age: - 18 and over Performance status: - Zubrod 0-2 Life expectancy: - Not specified Hematopoietic: - Absolute neutrophil count at least 1,500/mm^3 - Platelet count at least 100,000/mm^3 Hepatic: - Not specified Renal: - Creatinine clearance at least 50 mL/min Pulmonary: - One of the following: - FEV1 at least 2.0 L - Predicted FEV1 of contralateral lung greater than 800 mL - Predicted post-treatment FEV1 at least 1.0 L Other: - No other prior malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix - Not pregnant or nursing - Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: - No concurrent growth factors during induction chemoradiotherapy Chemotherapy: - No prior chemotherapy for lung cancer Endocrine therapy: - Not specified Radiotherapy: - No prior radiotherapy for lung cancer Surgery: - No prior surgical resection of lung cancer - Prior exploratory thoracotomy, mediastinoscopy, excisional biopsy, or similar surgery for determining diagnosis, stage, or potential resectability allowed
Total Enrollment:
Location and Contact Information:
Overall Study Official:
RajaMudad, Study Chair, Tulane University School of Medicine
USC/Norris Comprehensive Cancer Center and Hospital
Los Angeles, California, 90033-0804
United States
University of Kansas Medical Center
Kansas City, Kansas, 66160-7353
United States
Veterans Affairs Medical Center - San Antonio (Murphy)
San Antonio, Texas, 78284
United States
Veterans Affairs Medical Center - Phoenix (Carl T. Hayden)
Phoenix, Arizona, 85012
United States
Veterans Affairs Medical Center - Tucson
Tucson, Arizona, 85723
United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109-0912
United States
Veterans Affairs Medical Center - Portland
Portland, Oregon, 97207
United States
Veterans Affairs Medical Center - Shreveport
Shreveport, Louisiana, 71130
United States
Swedish Cancer Institute
Seattle, Washington, 98104
United States
Providence Hospital - Southfield
Southfield, Michigan, 48075-9975
United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78284-7845
United States
CCOP - Upstate Carolina
Spartanburg, South Carolina, 29303
United States
Veterans Affairs Medical Center - Detroit
Detroit, Michigan, 48201-1932
United States
Veterans Affairs Medical Center - Charleston
Charleston, South Carolina, 29401-5799
United States
CCOP - Duluth
Duluth, Minnesota, 55805
United States
Veterans Affairs Medical Center - Albuquerque
Albuquerque, New Mexico, 87108-5138
United States
Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital)
Hines, Illinois, 60141
United States
Veterans Affairs Medical Center - Kansas City
Kansas City, Missouri, 64128
United States
Chao Family Comprehensive Cancer Center
Orange, California, 92868
United States
CCOP - Santa Rosa Memorial Hospital
Santa Rosa, California, 95403
United States
Veterans Affairs Medical Center - Biloxi
Biloxi, Mississippi, 39531-2410
United States
Dwight David Eisenhower Army Medical Center
Fort Gordon, Georgia, 30905-5650
United States
CCOP - Grand Rapids Clinical Oncology Program
Grand Rapids, Michigan, 49503
United States
CCOP - Beaumont
Royal Oak, Michigan, 48073-6769
United States
CCOP - Greenville
Greenville, South Carolina, 29615
United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
United States
Veterans Affairs Medical Center - Denver
Denver, Colorado, 80220
United States
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, 90095-1781
United States
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201-1379
United States
CCOP - Columbus
Columbus, Ohio, 43206
United States
Louisiana State University Health Sciences Center - Shreveport
Shreveport, Louisiana, 71130-3932
United States
CCOP - Virginia Mason Research Center
Seattle, Washington, 98101
United States
Tripler Army Medical Center
Honolulu, Hawaii, 96859-5000
United States
CCOP - Cancer Research for the Ozarks
Springfield, Missouri, 65807
United States
Veterans Affairs Medical Center - Boston (Jamaica Plain)
Jamaica Plain, Massachusetts, 02130
United States
CCOP - Kansas City
Kansas City, Missouri, 64131
United States
Veterans Affairs Outpatient Clinic - Martinez
Martinez, California, 94553
United States
Herbert Irving Comprehensive Cancer Center
New York City, New York, 10032
United States
Baylor College of Medicine
Houston, Texas, 77030
United States
Brooke Army Medical Center
Fort Sam Houston, Texas, 78234-6200
United States
Oklahoma Medical Research Foundation
Oklahoma City, Oklahoma, 73104
United States
Veterans Affairs Medical Center - Wichita
Wichita, Kansas, 67218
United States
University of Rochester Medical Center
Rochester, New York, 14642
United States
Veterans Affairs Medical Center - Seattle
Seattle, Washington, 98108
United States
Veterans Affairs Medical Center - Ann Arbor
Ann Arbor, Michigan, 48105
United States
Veterans Affairs Medical Center - Oklahoma City
Oklahoma City, Oklahoma, 73104
United States
CCOP - Wichita
Wichita, Kansas, 67214-3882
United States
Albert B. Chandler Medical Center, University of Kentucky
Lexington, Kentucky, 40536-0084
United States
Veterans Affairs Medical Center - Houston
Houston, Texas, 77030
United States
CCOP - Northwest
Tacoma, Washington, 98405-0986
United States
CCOP - Southeast Cancer Control Consortium
Winston Salem, North Carolina, 27104-4241
United States
MBCCOP - Gulf Coast
Mobile, Alabama, 36688
United States
City of Hope Comprehensive Cancer Center
Duarte, California, 91010
United States
Veterans Affairs Medical Center - Salt Lake City
Salt Lake City, Utah, 84148
United States
Henry Ford Hospital
Detroit, Michigan, 48202
United States
University of Mississippi Medical Center
Jackson, Mississippi, 39216-4505
United States
CCOP - Central Illinois
Decatur, Illinois, 62526
United States
Loyola University Medical Center
Maywood, Illinois, 60153
United States
Veterans Affairs Medical Center - West Los Angeles
Los Angeles, California, 90073
United States
University of Colorado Cancer Center
Denver, Colorado, 80010
United States
University of Texas Medical Branch
Galveston, Texas, 77555-0565
United States
Veterans Affairs Medical Center - Albany
Albany, New York, 12208
United States
St. Louis University Health Sciences Center
St. Louis, Missouri, 63110
United States
Madigan Army Medical Center
Tacoma, Washington, 98431-5000
United States
CCOP - Montana Cancer Consortium
Billings, Montana, 59101
United States
OHSU Cancer Institute
Portland, Oregon, 97239
United States
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, 44195-9001
United States
MBCCOP - University of Illinois at Chicago
Chicago, Illinois, 60612-7323
United States
Veterans Affairs Medical Center - Little Rock (McClellan)
Little Rock, Arkansas, 72205
United States
CCOP - Columbia River Program
Portland, Oregon, 97225
United States
Veterans Affairs Medical Center - Jackson
Jackson, Mississippi, 39216
United States
Veterans Affairs Medical Center - Cincinnati
Cincinnati, Ohio, 45220-2288
United States
CCOP - Ann Arbor Regional
Ann Arbor, Michigan, 48106
United States
University of California Davis Medical Center
Sacramento, California, 95817
United States
CCOP - Dayton
Kettering, Ohio, 45429
United States
Cancer Research Center of Hawaii
Honolulu, Hawaii, 96813-2424
United States
CCOP - Bay Area Tumor Institute
Oakland, California, 94609-3305
United States
Veterans Affairs Medical Center - Dayton
Dayton, Ohio, 45428
United States
Huntsman Cancer Institute
Salt Lake City, Utah, 84112-5550
United States
Veterans Affairs Medical Center - Chicago (Westside Hospital)
Chicago, Illinois, 60612
United States
Arizona Cancer Center
Tucson, Arizona, 85724
United States
CCOP - Atlanta Regional
Atlanta, Georgia, 30342-1701
United States
Veterans Affairs Medical Center - Temple
Temple, Texas, 76504
United States
CCOP - Greater Phoenix
Phoenix, Arizona, 85006-2726
United States
David Grant Medical Center
Travis Air Force Base, California, 94535
United States
Medical University of South Carolina
Charleston, South Carolina, 29425-0721
United States
Barrett Cancer Center, The University Hospital
Cincinnati, Ohio, 45267-0501
United States
Veterans Affairs Medical Center - New Orleans
New Orleans, Louisiana, 70112
United States
CCOP - St. Louis-Cape Girardeau
St. Louis, Missouri, 63141
United States
CCOP - Scott and White Hospital
Temple, Texas, 76508
United States
Keesler Medical Center - Keesler AFB
Keesler AFB, Mississippi, 39534-2576
United States
MBCCOP-Howard University Cancer Center
Washington D.C., District of Columbia, 20060
United States
Tulane University School of Medicine
New Orleans, Louisiana, 70112
United States
MBCCOP - LSU Health Sciences Center
New Orleans, Louisiana, 70112
United States
Boston Medical Center
Boston, Massachusetts, 02118
United States
Veterans Affairs Medical Center - Lexington
Lexington, Kentucky, 40502-2236
United States
MBCCOP - University of New Mexico HSC
Albuquerque, New Mexico, 87131
United States
Additional Information:
Study ID Numbers: CDR0000068516; SWOG-S0022
Study Start Date:
Record last reviewed: March 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00014196
Other Large Cell Lung Cancer Studies:
1. Combination Chemotherapy With or Without Tirapazamine in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer
2. Chemotherapy and Radiation Therapy With or Without Efaproxiral in Treating Patients With Stage III Non-Small Cell Lung Cancer
3. Combination Chemotherapy Plus Radiation Therapy With or Without AE-941 in Treating Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed By Surgery
4. Video-Assisted Surgery Followed by Radiation Therapy in Treating Patients With Stage I Non-small Cell Lung Cancer and Poor Heart and Lung Function
5. Combination Chemotherapy Plus Radiation Therapy With or Without Gefitinib in Treating Patients With Unresectable Stage III Non-Small Cell Lung Cancer
Related Studies:
Other large cell lung cancer Clinical Trials
Other Michigan Clinical Trials
Other Grand Rapids Clinical Trials
Combination Chemotherapy and Radiation Therapy in Treating Patients With Stage IIIB Non-Small Cell Lung Cancer
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