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Home > "C" Clinical Trials Conditions > Collection of Blood from Patients with Pancytopenia  Collection of Blood from Patients with Pancytopenia
Collection of Blood from Patients with Pancytopenia
For Condition: Aplastic Anemia,Pancytopenia
Status: Recruiting
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: Aplastic anemia is a condition in which the cells normally found in blood are greatly decreased. The normal levels of white blood cells, red blood cells, and platelets are much lower in patients with aplastic anemia. Because of these low levels of blood cells, patients with aplastic anemia have a variety of immune system abnormalities. However, low levels of blood cells make it difficult to collect specialized white blood cells (mononuclear cells) for research studies. This study was designed to collect lymphocytes from patients with low levels of all blood cells (pancytopenia) for use in research. Patients participating in the study will undergo a special procedure known as lymphapheresis. During lymphapheresis blood is taken from the patient in a manner similar to blood donation. The white blood cells are selectively removed by spinning (centrifugation), and the remaining red blood cells and platelets are placed back (re-infused) into the donor's blood stream. Patients participating in this study will not benefit directly from it. However, cells collected in this study may increase scientific knowledge and improve understanding and treatment for diseases like aplastic anemia.
Details: Patients with aplastic anemia, myelodysplasia, and other marrow failure syndromes have a variety of immunologic abnormalities including lymphocyte phenotypic and lymphokine production dysregulation. Because of their low blood counts, it has been difficult to obtain sufficient peripheral blood mononuclear cells for research studies. Patients agreeing to this protocol will be lymphapheresed the equivalent of one or two units of cells (approximately 1-2 x 10(8) cells), which will be used for research purposes.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA All patients with aplastic anemia or other bone marrow failure in which we would not expect to obtain 1 X 10(8) mononuclear cells from 100 mls of peripheral blood (i.e. an absolute lymphocyte count approximately less than 2000 per mm(3)). Age 18 or older. EXCLUSION CRITERIA Patients unable to comprehend the investigational nature of the procedure. Patients unable to tolerate a temporary reduction of blood volume the equivalent of one unit of blood.
Total Enrollment: 40
Location and Contact Information:
National Heart, Lung and Blood Institute (NHLBI) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 860088; 86-H-0088
Study Start Date: April 30, 1986
Record last reviewed: April 22, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001214
Other Aplastic Anemia Studies:
1. Combination Therapy of Severe Aplastic Anemia
2. Stem Cell Mobilization Potential in Patients with Aplastic Anemia in remission
3. Megadose T-cell Depleted HLA-nonidentical Blood Progenitor Transplantation for Patients with Hematologic Malignancies or Bone Marrow Failure States
4. Mycophenolate Mofetil and Cyclosporine to Treat Relapsing Aplastic Anemia
5. Comparing Therapies for the Treatment of Severe Aplastic Anemia
Related Studies:
Other Aplastic Anemia Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Collection of Blood from Patients with Pancytopenia
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